| Title | 2-[F-18]FDG PET/CT parameters associated with WHO/ISUP grade in clear cell renal cell carcinoma |
| Authors | Zhao, Yanyan Wu, Caixia Li, Wei Chen, Xueqi Li, Ziao Liao, Xuhe Cui, Yonggang Zhao, Guangyu Liu, Meng Fu, Zhanli |
| Affiliation | Peking Univ, Dept Nucl Med, Hosp 1, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Dept Nucl Med, Beijing, Peoples R China Peking Univ, Dept Urol, Hosp 1, Beijing, Peoples R China |
| Keywords | FDG-PET/CT IMAGING FEATURES TUMOR THROMBUS FUHRMAN GRADE TOMOGRAPHY SYSTEM SUV SOCIETY SIZE CT |
| Issue Date | Aug-2020 |
| Publisher | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Abstract | Purpose To explore the potential parameters from preoperative 2-[F-18]FDG PET/CT that might associate with the World Health Organization/the International Society of Urological Pathology (WHO/ISUP) grade in clear cell renal cell carcinoma (ccRCC). Methods One hundred twenty-five patients with newly diagnosed ccRCC who underwent 2-[F-18]FDG PET/CT prior to surgery or biopsy were retrospectively reviewed. The metabolic parameters and imaging features obtained from 2-[F-18]FDG PET/CT examinations were analyzed in combination with clinical characteristics. Univariate and multivariate logistic regression analyses were performed to identify the predictive factors of WHO/ISUP grade. Results Metabolic parameters of primary tumor maximum standardized uptake value (SUVmax), tumor-to-liver SUV ratio (TLR), and tumor-to-kidney SUV ratio (TKR) were significantly different between any two of the four different WHO/ISUP grades, except those between the WHO/ISUP grade 3 and grade 4. The optimal cutoff values to predict high WHO/ISUP grade for SUVmax, TLR, and TKR were 4.15, 1.63, and 1.59, respectively. TLR (AUC: 0.841) was superior to TKR (AUC: 0.810) in distinguishing high and low WHO/ISUP grades (P = 0.0042). In univariate analysis, SUVmax, TLR, TKR, primary tumor size, tumor thrombus, distant metastases, and clinical symptoms could discriminate between the high and low WHO/ISUP grades (P < 0.05). In multivariate analysis, TLR (P < 0.001; OR: 1.732; 95%CI: 1.289-2.328) and tumor thrombus (P < 0.001; OR: 6.199; 95%CI: 2.499-15.375) were significant factors for differentiating WHO/ISUP grades. Conclusion Elevated TLR (> 1.63) and presence of tumor thrombus from preoperative 2-[F-18]FDG PET/CT can distinguish high WHO/ISUP grade ccRCC effectively. 2-[F-18]FDG PET/CT may be a feasible method for noninvasive assessment of WHO/ISUP grade. |
| URI | http://hdl.handle.net/20.500.11897/607485 |
| ISSN | 1619-7070 |
| DOI | 10.1007/s00259-020-04996-4 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
