| Title | Comparative study between chronic immune thrombocytopenia patients and healthy population on Epstein-Barr virus infection status by polymerase chain reaction |
| Authors | Yan, Miao Zhang, Ying Yang, Fan Ji, Li Wang, Mangju Wang, Wensheng |
| Affiliation | Peking Univ, Hosp 1, Dept Hematol, 8 Xishiku St, Beijing 100034, Peoples R China |
| Keywords | EBV DNA PURPURA PLASMA CYTOMEGALOVIRUS CHILDREN ADULTS |
| Issue Date | Jun-2020 |
| Publisher | EXPERT REVIEW OF HEMATOLOGY |
| Abstract | Background Immune thrombocytopenia (ITP) has been known to be associated with assorted virus infections. This study aims to investigate the Epstein-Barr virus infection status in chronic ITP patients by real-time quantitative polymerase chain reaction. Methods 42 chronic ITP patients and 42 healthy donors were retrospectively included via propensity score matching with gender and age. EBV-DNA levels in whole blood of patients and donors were assessed by RT-qPCR, and correlations between virus load and platelet count were analyzed. Results The positive rate of EBV-DNA in lymphocytes of chronic ITP patients was significantly higher than that in donors (52.4% vs 31.0%, p = 0.046). Platelet count [18(8-45)x10(9)/L] of patients with high virus load in lymphocytes was significantly lower than that [51(30-87)x10(9)/L] of patients with low virus load (p = 0.0001), whereas no difference was observed in platelet count between EBV-DNA-positive and negative subgroups of donors (p = 0.984). And a significant inverse correlation was observed between EBV-DNA levels in lymphocytes and platelet count (r = -0.4958, p = 0.019) in patients, which was independent from the presence of platelet-associated IgG. Conclusions EBV infection has a potential role in the development of chronic ITP. Identification and control of this underlying infection should be emphasized in the treatment of chronic ITP. |
| URI | http://hdl.handle.net/20.500.11897/607134 |
| ISSN | 1747-4086 |
| DOI | 10.1080/17474086.2020.1772746 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
