| Title | Down-regulation of long non-coding RNA MEG3 promotes Schwann cell proliferation and migration and repairs sciatic nerve injury in rats |
| Authors | Ma, Yongbin Zhai, Dongwang Zhang, Wenzhe Zhang, Huanyan Dong, Liyang Zhou, Yuepeng Feng, Dingqi Zheng, Yu Wang, Ting Mao, Chaoming Wang, Xuefeng |
| Affiliation | Jiangsu Univ, Dept Cent Lab, Affiliated Hosp, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China Nanjing Med Univ, Dept Pathogen Biol & Immunol, Jiangsu Key Lab Pathogen Biol, Nanjing, Peoples R China Jiangsu Univ, Jintan Hosp, Dept Neurol Lab, Jintan, Peoples R China Peking Univ, Aerosp Ctr Hosp, Dept Clin Lab, Beijing, Peoples R China Jiangsu Univ, Affiliated Hosp, Dept Nucl Med, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China Jiangsu Univ, Affiliated Hosp, Inst Oncol, 438 Jiefang Rd, Zhenjiang 212001, Jiangsu, Peoples R China |
| Keywords | DORSAL-ROOT GANGLION NEURITE OUTGROWTH REGENERATION NEURONS GROWTH TUMOR MECHANISMS GENE |
| Issue Date | May-2020 |
| Publisher | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE |
| Abstract | Peripheral nerve injury and regeneration are complex processes and involve multiple molecular and signalling components. However, the involvement of long non-coding RNA (lncRNA) in this process is not fully clarified. In this study, we evaluated the expression of the lncRNA maternally expressed gene 3 (MEG3) in rats after sciatic nerve transection and explored its potential mechanisms. The expression of lncRNA MEG3 was up-regulated following sciatic nerve injury and observed in Schwann cells (SCs). The down-regulation of lncRNA MEG3 in SCs enhanced the proliferation and migration of SCs via the PTEN/PI3K/AKT pathway. The silencing of lncRNA MEG3 promoted the migration of SCs and axon outgrowth in rats after sciatic nerve transection and facilitated rat nerve regeneration and functional recovery. Our findings indicated that lncRNA MEG3 may be involved in nerve injury and injured nerve regeneration in rats with sciatic nerve defects by regulating the proliferation and migration of SCs. This gene may provide a potential therapeutic target for improving peripheral nerve injury. |
| URI | http://hdl.handle.net/20.500.11897/606907 |
| ISSN | 1582-1838 |
| DOI | 10.1111/jcmm.15368 |
| Indexed | SCI(E) Scopus |
| Appears in Collections: | 北京航天中心医院 |
