| Title | ENIGMA-DTI: Translating reproducible white matter deficits into personalized vulnerability metrics in cross-diagnostic psychiatric research |
| Authors | Kochunov, Peter Hong, L. Elliot Dennis, Emily L. Morey, Rajendra A. Tate, David F. Wilde, Elisabeth A. Logue, Mark Kelly, Sinead Donohoe, Gary Favre, Pauline Houenou, Josselin Ching, Christopher R. K. Holleran, Laurena Andreassen, Ole A. Velzen, Laura S. Schmaal, Lianne Villalon-Reina, Julio E. Bearden, Carrie E. Piras, Fabrizio Spalletta, Gianfranco Heuvel, Odile A. Veltman, Dick J. Stein, Dan J. Ryan, Meghann C. Tan, Yunlong Erp, Theo G. M. Turner, Jessica A. Haddad, Liz Nir, Talia M. Glahn, David C. Thompson, Paul M. Jahanshad, Neda |
| Affiliation | Univ Maryland, Sch Med, Dept Psychiat, Maryland Psychiat Res Ctr, Baltimore, MD 21201 USA Brigham & Womens Hosp, Psychiat Neuroimaging Lab, 75 Francis St, Boston, MA 02115 USA Keck Sch Med USC, USC Mark & Mary Stevens Neuroimaging & Informat I, Imaging Genet Ctr, Marina Del Rey, CA USA Univ Utah, Sch Med, Dept Neurol, Salt Lake City, UT USA George E Wahlen VA, Salt Lake City, UT USA Duke Univ, Brain Imaging & Anal Ctr, Durham, NC USA Natl Ctr PTSD, VA Boston Healthcare Syst, Boston, MA USA Boston Univ, Sch Med, Dept Psychiat, Boston, MA 02118 USA Boston Univ, Sch Med, Biomed Genet, Boston, MA 02118 USA Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USA Harvard Med Sch, Boston, MA 02115 USA Natl Univ Ireland Galway, NCBES Galway Neurosci Ctr, Ctr Neuroimaging & Cognit Genom NICOG, Clin Neuroimaging Lab, Galway, Ireland Univ Paris Saclay, CEA, Neurospin, Gif Sur Yvette, France INSERM, Unit U955, Team Translat Neuropsychiat, Creteil, France CHU Mondor, AP HP, Dept Psychiat, Creteil, France Univ Paris Est Creteil, Fac Med, Creteil, France Oslo Univ Hosp, Div Mental Hlth & Addict, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway Univ Oslo, Inst Clin Med, Norwegian Ctr Mental Disorders Res NORMENT, Oslo, Norway Univ Melbourne, Ctr Youth Mental Hlth, Melbourne, Vic, Australia Orygen, Parkville, Vic, Australia Univ Calif Los Angeles, Dept Psychiat & Biobehav Sci, Semel Inst Neurosci & Human Behav, Los Angeles, CA 90024 USA Univ Calif Los Angeles, Dept Psychol, Los Angeles, CA USA IRCCS Santa Lucia Fdn, Dept Clin & Behav Neurol, Lab Neuropsychiat, Rome, Italy Baylor Coll Med, Menninger Dept Psychiat & Behav Sci, Div Neuropsychiat, Houston, TX 77030 USA Vrije Univ Amsterdam, Dept Anat & Neurosci, Amsterdam UMC, Dept Psychiat,Amsterdam Neurosci, Amsterdam, Netherlands Univ Cape Town, SA MRC Unit Risk & Resilience Mental Disorders, Dept Psychiat, Cape Town, South Africa Univ Cape Town, SA MRC Unit Risk & Resilience Mental Disorders, Inst Neurosci, Cape Town, South Africa Peking Univ, Beijing Huilongguan Hosp, Huilongguan Clin Med Sch, Beijing, Peoples R China Univ Calif Irvine, Dept Psychiat, Clin Translat Neurosci Lab, Irvine, CA 92717 USA Univ Calif Irvine, Ctr Neurobiol Learning & Memory, Irvine, CA 92717 USA Georgia State Univ, Dept Psychol, Univ Plaza, Atlanta, GA 30303 USA Georgia State Univ, Inst Neurosci, Atlanta, GA 30303 USA Boston Childrens Hosp, Dept Psychiat, Boston, MA USA Harvard Med Sch, Boston, MA 02115 USA Hartford Hosp, Olin Neuropsychiat Res Ctr, Hartford, CT 06115 USA |
| Keywords | REDUCED FRACTIONAL ANISOTROPY CORPUS-CALLOSUM DIFFUSION SCHIZOPHRENIA INTEGRITY HERITABILITY MULTISITE DECLINE PROJECT WATER |
| Issue Date | Apr-2020 |
| Publisher | HUMAN BRAIN MAPPING |
| Abstract | The ENIGMA-DTI (diffusion tensor imaging) workgroup supports analyses that examine the effects of psychiatric, neurological, and developmental disorders on the white matter pathways of the human brain, as well as the effects of normal variation and its genetic associations. The seven ENIGMA disorder-oriented working groups used the ENIGMA-DTI workflow to derive patterns of deficits using coherent and coordinated analyses that model the disease effects across cohorts worldwide. This yielded the largest studies detailing patterns of white matter deficits in schizophrenia spectrum disorder (SSD), bipolar disorder (BD), major depressive disorder (MDD), obsessive-compulsive disorder (OCD), posttraumatic stress disorder (PTSD), traumatic brain injury (TBI), and 22q11 deletion syndrome. These deficit patterns are informative of the underlying neurobiology and reproducible in independent cohorts. We reviewed these findings, demonstrated their reproducibility in independent cohorts, and compared the deficit patterns across illnesses. We discussed translating ENIGMA-defined deficit patterns on the level of individual subjects using a metric called the regional vulnerability index (RVI), a correlation of an individual's brain metrics with the expected pattern for a disorder. We discussed the similarity in white matter deficit patterns among SSD, BD, MDD, and OCD and provided a rationale for using this index in cross-diagnostic neuropsychiatric research. We also discussed the difference in deficit patterns between idiopathic schizophrenia and 22q11 deletion syndrome, which is used as a developmental and genetic model of schizophrenia. Together, these findings highlight the importance of collaborative large-scale research to provide robust and reproducible effects that offer insights into individual vulnerability and cross-diagnosis features. |
| URI | http://hdl.handle.net/20.500.11897/606656 |
| ISSN | 1065-9471 |
| DOI | 10.1002/hbm.24998 |
| Indexed | SCI(E) Scopus |
| Appears in Collections: | 北京回龙观医院 |
