| Title | Sleep duration and risk of cardiovascular events: The SAVE study |
| Authors | Li, Jingwei Zheng, Danni Loffler, Kelly A. Wang, Xia McEvoy, R. Doug Woodman, Richard J. Luo, Yuanming Lorenzi-Filho, Geraldo Barbe, Ferran Tripathi, Manjari Anderson, Craig S. |
| Affiliation | Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China Third Mil Med Univ, Xinqiao Hosp, Dept Cardiol, Chongqing, Peoples R China Univ New South Wales, George Inst Global Hlth, Sydney, NSW, Australia Univ New South Wales, Ctr Big Data Res Hlth, Sydney, NSW, Australia Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide Inst Sleep Hlth, Adelaide, SA, Australia Flinders Univ S Australia, Coll Med & Publ Hlth, Ctr Biostat & Epidemiol, Adelaide, SA, Australia Guangzhou Med Univ, Affiliated Hosp 1, State Key Lab Resp Dis, Guangzhou, Peoples R China Univ Sao Paulo, Heart Inst, Inst Coracao, Sao Paulo, Brazil Inst Recerca Biomed Lleida, Ctr Invest Biomed Red Enfermedades Resp, Resp Dept, Madrid, Spain All India Inst Med Sci, Dept Neurol, New Delhi, India Peking Univ, Hlth Sci Ctr, George Inst China, Beijing, Peoples R China Royal Prince Alfred Hosp, Neurol Dept, Sydney Hlth Partners, Sydney, NSW, Australia Heart Hlth Res Ctr, Beijing, Peoples R China Univ Desarrollo, Ctr Clin Studies, Sch Med Clin Alemana, Inst Ciencias & Innovac Med, Santiago, Chile |
| Keywords | APNEA HEALTH METAANALYSIS ASSOCIATION STROKE POPULATION MORTALITY QUALITY DISEASE IMPACT |
| Issue Date | Feb-2020 |
| Publisher | INTERNATIONAL JOURNAL OF STROKE |
| Abstract | Background and aim Controversy exists regarding cardiovascular risk in relation to sleep duration. We determined sleep duration and major recurrent cardiovascular event associations in patients with obstructive sleep apnoea and established cardiovascular disease. Methods Secondary analyses of the international, multicenter, Sleep Apnea Cardiovascular Endpoints trial. Sleep duration was estimated from overnight home oximetry (ApneaLink monitor) used for obstructive sleep apnoea diagnosis. Cox proportional hazards models were used to determine associations of categorized sleep duration (<6 h, 6-8 h (reference), and >8 h) and major cardiovascular outcomes: primary composite of cardiovascular death, non-fatal myocardial infarction, non-fatal stroke, and any hospitalization for unstable angina, heart failure, or transient ischemic attack; secondary composite of cardiac and cerebral (stroke/transient ischemic attack) events. Results Oximetry-derived sleep duration estimates were available in 2687 participants (mean 61.2 years, 80.9% males) who experienced a total of 436 cardiovascular events over a mean follow-up of 3.7 years. Compared to the reference category, sleep duration was not associated with risk of the primary composite cardiovascular outcome (adjusted hazard ratio (HR) 1.00, 95% confidence interval 0.76-1.33, and HR 1.22, 95% confidence interval 0.98-1.52, for sleep duration 8 h, respectively). However, long sleep was associated with increased cerebral events (HR 1.67, 95% confidence interval 1.17-2.39; P = 0.005) and stroke alone (HR 1.79, 95% confidence interval 1.22-2.63; P = 0.003). Conclusions Long sleep duration is associated with an increased risk of stroke but not cardiac events in obstructive sleep apnoea patients with existing cardiovascular disease. |
| URI | http://hdl.handle.net/20.500.11897/606414 |
| ISSN | 1747-4930 |
| DOI | 10.1177/1747493020904913 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
