| Title | Peripheral cytotoxic T lymphocyte predicts first-line progression free survival in HER2-positive advanced breast cancer |
| Authors | Liu, Xiao-Ran Yu, Jian-Jun Song, Guo-Hong Di, Li-Jun Jiang, Han-Fang Yan, Ying Liang, Xu Zhang, Ru-Yan Ran, Ran Wang, Jing Bai, Han Jia, Shi-Dong Li, Hui-Ping |
| Affiliation | Peking Univ, Dept Breast Oncol, Key Lab Carcinogenesis & Translat Res, Minist Educ,Canc Hosp & Inst, Fu Cheng Rd 52, Beijing 100142, Peoples R China Huidu Shanghai Med Sci, Wang Yuan Rd 1698, Shanghai 201499, Peoples R China |
| Keywords | TUMOR-INFILTRATING LYMPHOCYTES PROGNOSTIC VALUE CELLS RECURRENCE THERAPY COUNT |
| Issue Date | Feb-2021 |
| Publisher | BREAST |
| Abstract | Background: The role of peripheral blood lymphocyte (pBL) in breast cancer has long been studied. However, the predictive role of pBL in advanced breast cancer (ABC) is poorly understood. Methods: A total of 303 patients with ABC were consecutively recruited at our center between January 2015 and September 2019. At baseline, pBL subtypes were detected in all patients with 229 blood samples available for circulating tumor DNA (ctDNA) detection. pBL was analyzed through flow cytometry. ctDNA-based gene mutations were detected using next generation sequencing. The cutoff value of pCTL was estimated by X-tile software. Progression free survival (PFS) was estimated by Kaplan-Meier curve and Cox hazard proportion regression model, with difference detection by log-rank test. Results: Median follow-up time of the study was 21.0 months. The median age of diagnosis was 52.0 years. Among the pBL subtypes, only pCTL level was found predictive for PFS in the HER2+ patients whom received anti-HER2 therapy (13.1 vs. 5.6 months, P = 0.001). However, the predictive role of pCTL was not found in HR-positive (P = 0.716) and TNBC (P = 0.202). pCTL high associated with suppressive immune indictors including lower CD4/CD8 ratio (P = 0.004) and high level of Treg cell (P = 0.004). High occurrence of FGFR1 amplification which has been reported as immune suppressor was also found in HER2+ patients with pCTL high (22.2% vs. 4.3%, P = 0.048). Conclusions: Higher pCTLs level associated with shorter PFS and FGFR1 mutation in HER2+ ABC patients. (C) 2020 The Authors. Published by Elsevier Ltd. |
| URI | http://hdl.handle.net/20.500.11897/605695 |
| ISSN | 0960-9776 |
| DOI | 10.1016/j.breast.2020.11.006 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
