| Title | Identification of type 2 diabetes loci in 433,540 East Asian individuals |
| Authors | Spracklen, Cassandra N. Horikoshi, Momoko Kim, Young Jin Lin, Kuang Bragg, Fiona Moon, Sanghoon Suzuki, Ken Tam, Claudia H. T. Tabara, Yasuharu Kwak, Soo-Heon Takeuchi, Fumihiko Long, Jirong Lim, Victor J. Y. Chai, Jin-Fang Chen, Chien-Hsiun Nakatochi, Masahiro Yao, Jie Choi, Hyeok Sun Iyengar, Apoorva K. Perrin, Hannah J. Brotman, Sarah M. Van De Bunt, Martijn Gloyn, Anna L. Below, Jennifer E. Boehnke, Michael Bowden, Donald W. Chambers, John C. Mahajan, Anubha McCarthy, Mark I. Ng, Maggie C. Y. Petty, Lauren E. Zhang, Weihua Morris, Andrew P. Adair, Linda S. Akiyama, Masato Bian, Zheng Chan, Juliana C. N. Chang, Li-Ching Chee, Miao-Li Chen, Yii-Der Ida Chen, Yuan-Tsong Chen, Zhengming Chuang, Lee-Ming Du, Shufa Gordon-Larsen, Penny Gross, Myron Guo, Xiuqing Guo, Yu Han, Sohee Howard, Annie-Green Huang, Wei Hung, Yi-Jen Hwang, Mi Yeong Hwu, Chii-Min Ichihara, Sahoko Isono, Masato Jang, Hye-Mi Jiang, Guozhi Jonas, Jost B. Kamatani, Yoichiro Katsuya, Tomohiro Kawaguchi, Takahisa Khor, Chiea-Chuen Kohara, Katsuhiko Lee, Myung-Shik Lee, Nanette R. Li, Liming Liu, Jianjun Luk, Andrea O. Lv, Jun Okada, Yukinori Pereira, Mark A. Sabanayagam, Charumathi Shi, Jinxiu Shin, Dong Mun So, Wing Yee Takahashi, Atsushi Tomlinson, Brian Tsai, Fuu-Jen van Dam, Rob M. Xiang, Yong-Bing Yamamoto, Ken Yamauchi, Toshimasa Yoon, Kyungheon Yu, Canqing Yuan, Jian-Min Zhang, Liang Zheng, Wei Igase, Michiya Cho, Yoon Shin Rotter, Jerome I. Wang, Ya-Xing Sheu, Wayne H. H. Yokota, Mitsuhiro Wu, Jer-Yuarn Cheng, Ching-Yu Wong, Tien-Yin Shu, Xiao-Ou Kato, Norihiro Park, Kyong-Soo Tai, E-Shyong Matsuda, Fumihiko Koh, Woon-Puay Ma, Ronald C. W. Maeda, Shiro Millwood, Iona Y. Lee, Juyoung Kadowaki, Takashi Walters, Robin G. Kim, Bong-Jo Mohlke, Karen L. Sim, Xueling |
| Affiliation | Univ N Carolina, Dept Genet, Chapel Hill, NC 27515 USA Univ Massachusetts, Sch Publ Hlth & Hlth Sci, Dept Biostat & Epidemiol, Amherst, MA 01003 USA RIKEN Ctr Integrat Med Sci, Lab Endocrinol Metab & Kidney Dis, Yokohama, Kanagawa, Japan Natl Inst Hlth, Div Genome Res, Ctr Genome Sci, Osong Eup, Chungcheongbuk, South Korea Univ Oxford, Nuffield Dept Populat Hlth, Oxford, England RIKEN Ctr Integrat Med Sci, Lab Stat & Translat Genet, Yokohama, Kanagawa, Japan Univ Tokyo, Grad Sch Med, Dept Diabet & Metab Dis, Tokyo, Japan Osaka Univ, Dept Stat Genet, Grad Sch Med, Osaka, Japan Chinese Univ Hong Kong, Dept Med & Therapeut, Hong Kong, Peoples R China Chinese Univ Hong Kong, Chinese Univ Hong Kong Shanghai Jiao Tong Univ Jo, Hong Kong, Peoples R China Kyoto Univ, Ctr Genom Med, Grad Sch Med, Kyoto, Japan Seoul Natl Univ Hosp, Dept Internal Med, Seoul, South Korea Natl Ctr Global Hlth & Med, Res Inst, Dept Gene Diagnost & Therapeut, Tokyo, Japan Vanderbilt Univ, Med Ctr, Dept Med, Div Epidemiol, Nashville, TN USA Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore Natl Univ Hlth Syst, Singapore, Singapore Acad Sinica, Inst Biomed Sci, Taipei, Taiwan Nagoya Univ, Dept Integrated Hlth Sci, Grad Sch Med, Nagoya, Aichi, Japan Harbor UCLA Med Ctr, Lundquist Inst Biomed Innovat, Inst Translat Genom & Populat Sci, Torrance, CA 90509 USA Univ Calif Los Angeles, Sch Med, Dept Pediat, Harbor UCLA Med Ctr, Torrance, CA 90509 USA Hallym Univ, Biomed Sci, Chunchon, South Korea Univ Oxford, Oxford Ctr Diabet Endocrinol & Metab, Oxford, England Univ Oxford, Wellcome Ctr Human Genet, Oxford, England Oxford Univ Hosp NHS Fdn Trust, Churchill Hosp, Oxford NIHR Biomed Res Ctr, Oxford, England Vanderbilt Univ, Med Ctr, Div Med Genet, Vanderbilt Genet Inst, Nashville, TN USA Univ Texas Hlth Sci Ctr Houston, Sch Publ Hlth, Human Genet Ctr, Houston, TX 77030 USA Univ Michigan, Dept Biostat, Ann Arbor, MI 48109 USA Univ Michigan, Ctr Stat Genet, Ann Arbor, MI 48109 USA Wake Forest Sch Med, Ctr Genom & Personalized Med Res, Ctr Diabet Res, Winston Salem, NC 27101 USA Wake Forest Sch Med, Dept Biochem, Winston Salem, NC 27101 USA Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore, Singapore Imperial Coll London, Dept Epidemiol & Biostat, London, England London North West Healthcare NHS Trust, Ealing Hosp, Dept Cardiol, London, England Imperial Coll London, Imperial Coll Healthcare NHS Trust, London, England Imperial Coll London, MRC PHE Ctr Environm & Hlth, London, England Univ Liverpool, Dept Biostat, Liverpool, Merseyside, England Univ Manchester, Sch Biol Sci, Manchester, Lancs, England Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Nutr, Chapel Hill, NC 27515 USA RIKEN Ctr Integrat Med Sci, Lab Stat Anal, Yokohama, Kanagawa, Japan Kyushu Univ, Grad Sch Med Sci, Dept Ophthalmol, Fukuoka, Japan Chinese Acad Med Sci, Beijing, Peoples R China Chinese Univ Hong Kong, Hong Kong Inst Diabet & Obes, Hong Kong, Peoples R China Chinese Univ Hong Kong, Li Ka Shing Inst Hlth Sci, Hong Kong, Peoples R China Singapore Natl Eye Ctr, Singapore Eye Res Inst, Singapore, Singapore Natl Taiwan Univ Hosp, Dept Internal Med, Div Endocrinol Metab, Taipei, Taiwan Natl Taiwan Univ, Sch Publ Hlth, Inst Prevent Med, Taipei, Taiwan Univ Minnesota, Dept Lab Med & Pathol, Minneapolis, MN 55455 USA Univ N Carolina, Gillings Sch Global Publ Hlth, Carolina Populat Ctr, Dept Biostat, Chapel Hill, NC 27515 USA Chinese Natl Human Genome Ctr Shanghai, Shanghai MOST Key Lab Hlth & Dis Genom, Dept Genet, Shanghai, Peoples R China Tri Serv Gen Hosp Songshan Branch, Div Endocrine & Metab, Taipei, Taiwan Natl Def Med Ctr, Sch Med, Taipei, Taiwan Taipei Vet Gen Hosp, Dept Med, Sect Endocrinol & Metab, Taipei, Taiwan Natl Yang Ming Univ, Sch Med, Taipei, Taiwan Jichi Med Univ, Sch Med, Dept Environm & Prevent Med, Shimotsuke, Tochigi, Japan Heidelberg Univ, Med Fac Mannheim, Dept Ophthalmol, Mannheim, Germany Univ Tokyo, Grad Sch Frontier Sci, Dept Computat Biol & Med Sci, Lab Complex Trait Genom, Tokyo, Japan Osaka Univ, Dept Clin Gene Therapy, Grad Sch Med, Osaka, Japan Osaka Univ, Grad Sch Med, Dept Geriatr & Gen Med, Osaka, Japan Agcy Sci Technol & Res, Genome Inst Singapore, Singapore, Singapore Ehime Univ, Fac Collaborat Reg Innovat, Dept Reg Resource Management, Matsuyama, Ehime, Japan Yonsei Univ, Coll Med, Severance Biomed Sci Inst, Seoul, South Korea Yonsei Univ, Coll Med, Dept Internal Med, Seoul, South Korea Sungkyunkwan Univ, Sch Med, Samsung Med Ctr, Dept Med, Seoul, South Korea Univ San Carlos, Dept Anthropol Sociol & Hist, Cebu, Philippines Peking Univ, Peking Univ Hlth Sci Ctr, Dept Epidemiol & Biostat, Beijing, Peoples R China Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Med, Singapore, Singapore Natl Univ Hlth Syst, Singapore, Singapore Osaka Univ, Immunol Frontier Res Ctr WPI IFReC, Lab Stat Immunol, Osaka, Japan Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA Duke NUS Med Sch, Ophthalmol & Visual Sci Acad Clin Program Eye ACP, Singapore, Singapore Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Ophthalmol, Singapore, Singapore Natl Univ Hlth Syst, Singapore, Singapore Natl Cerebral & Cardiovasc Ctr, Dept Genom Med, Osaka, Japan Macau Univ Sci & Technol, Fac Med, Macau, Peoples R China China Med Univ Hosp, Dept Med Genet & Med Res, Taichung, Taiwan Shanghai Jiao Tong Univ, State Key Lab Oncogene & Related Genes, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China Shanghai Jiao Tong Univ, Dept Epidemiol, Shanghai Canc Inst, Renji Hosp,Sch Med, Shanghai, Peoples R China Kurume Univ, Sch Med, Dept Med Biochem, Kurume, Fukuoka, Japan Univ Pittsburgh, UPMC Hillman Canc Ctr, Div Canc Control & Populat Sci, Pittsburgh, PA USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Ehime Univ, Grad Sch Med, Dept Antiaging Med, Matsuyama, Ehime, Japan Capital Med Univ, Beijing Tongren Hosp, Ophthalmol & Visual Sci Key Lab, Beijing Inst Ophthalmol, Beijing, Peoples R China Taichung Vet Gen Hosp, Dept Med, Div Endocrinol & Metab, Taichung, Taiwan Kurume Univ, Sch Med, Kurume, Fukuoka, Japan Seoul Natl Univ, Depr Internal Med, Coll Med, Seoul, South Korea Seoul Natl Univ, Grad Sch Convergence Sci & Technol, Dept Mol Med & Biopharmaceut Sci, Seoul, South Korea Duke NUS Med Sch, Singapore, Singapore Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore Univ Ryukyus, Grad Sch Med, Dept Adv Genom & Lab Med, Okinawa, Japan Univ Ryukyus Hosp, Div Clin Lab & Blood Transfus, Okinawa, Japan Univ Oxford, Med Res Council Populat Hlth Res Unit, Oxford, England Stanford Univ, Stanford, CA 94305 USA Genentech Inc, San Francisco, CA 94080 USA |
| Issue Date | 11-Jun-2020 |
| Publisher | NATURE |
| Abstract | Meta-analyses of genome-wide association studies (GWAS) have identified more than 240 loci that are associated with type 2 diabetes (T2D)1,2; however, most of these loci have been identified in analyses of individuals with European ancestry. Here, to examine T2D risk in East Asian individuals, we carried out a meta-analysis of GWAS data from 77,418 individuals with T2D and 356,122 healthy control individuals. In the main analysis, we identified 301 distinct association signals at 183 loci, and across T2D association models with and without consideration of body mass index and sex, we identified 61 loci that are newly implicated in predisposition to T2D. Common variants associated with T2D in both East Asian and European populations exhibited strongly correlated effect sizes. Previously undescribed associations include signals in or near GDAP1, PTF1A, SIX3, ALDH2, a microRNA cluster, and genes that affect the differentiation of muscle and adipose cells3. At another locus, expression quantitative trait loci at two overlapping T2D signals affect two genes-NKX6-3 and ANK1-in different tissues4-6. Association studies in diverse populations identify additional loci and elucidate disease-associated genes, biology, and pathways. |
| URI | http://hdl.handle.net/20.500.11897/605223 |
| ISSN | 0028-0836 |
| DOI | 10.1038/s41586-020-2263-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 医学部待认领 |
