| Title | Association Between Lipoprotein(a) and Peri-procedural Myocardial Infarction in Patients With Diabetes Mellitus Who Underwent Percutaneous Coronary Intervention |
| Authors | Liu, Yupeng Wang, Wenyao Song, Jingjing Zhang, Kuo Xu, Bo Li, Ping Shao, Chunli Yang, Min Chen, Jing Tan, Yi-Da |
| Affiliation | Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, Natl Ctr Cardiovasc Dis, Dept Cardiol,State Key Lab Cardiovasc Dis, Beijing, Peoples R China Peking Univ, Dept Cardiol, Hosp 3, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Grad Sch, Peking Union Med Coll, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Dept Cardiac Catheterizat Lab, State Key Lab Cardiovasc Dis, Fuwai Hosp,Natl Ctr Cardiovasc Dis, Beijing, Peoples R China |
| Issue Date | 3-Feb-2021 |
| Publisher | FRONTIERS IN ENDOCRINOLOGY |
| Abstract | Background High lipoprotein(a) (Lp[a]) levels are associated with increased risks of cardiovascular events in Percutaneous Coronary Intervention (PCI) patients with diabetes mellitus (DM). Peri-procedural myocardial infarction (PMI) occurs commonly during the PCI, whereas the relationship between Lp(a) and PMI remains unclear. Our study aimed to evaluate the association between Lp(a) value and the incidence of PMI in a larger-scale diabetic cohort undergoing PCI throughout 2013. Methods A total of 2,190 consecutive patients with DM were divided into two groups according to the median Lp(a) level of 175 mg/L: Low Lp(a) group (N = 1095) and high Lp(a) group (N = 1095). PMI was defined based on the 2018 universal definition of myocardial infarction. Results Patients with high Lp(a) levels exhibited higher rates of PMI compared to those with low Lp(a) levels (2.3% versus 0.8%, P = 0.006). The multivariable logistic analysis showed that PMI was independently predicted by Lp(a) as a dichotomous variable (OR 2.64, 95%CI 1.22-5.70) and as a continuous variable (OR 1.57, 95% CI 1.12-2.20). However, further investigation found that this association was only maintained in men, whose Lp(a) levels were significantly associated with the frequency of PMI, both as a dichotomous variable (OR 3.66, 95%CI 1.34-10.01) and as a continuous variable (OR 1.81, 95%CI 1.18-2.78). Lp(a) wasn't a risk factor of PMI in women. Conclusions High Lp(a) levels had forceful correlations with the increased frequency of PMI in male diabetic patients undergoing PCI. Lp(a) might act as a marker of risk stratification and a therapeutic target to reduce PCI-related ischemic events. |
| URI | http://hdl.handle.net/20.500.11897/605008 |
| ISSN | 1664-2392 |
| DOI | 10.3389/fendo.2020.603922 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
