| Title | Enhanced Hemocompatibility of a Direct Chemical Vapor Deposition-Derived Graphene Film |
| Authors | Meng, Xuejuan Cheng, Yi Wang, Puxin Chen, Ke Chen, Zhaolong Liu, Xiaojun Fu, Xuefeng Wang, Kun Liu, Kaihui Liu, Zhongfan Duan, Xiaojie |
| Affiliation | Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China Peking Univ, Coll Chem & Mol Engn, Beijing 100871, Peoples R China Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China Peking Univ, Frontiers Sci Ctr Nanooptoelect, Sch Phys, State Key Lab Mesoscop Phys, Beijing 100871, Peoples R China |
| Issue Date | 3-Feb-2021 |
| Publisher | ACS APPLIED MATERIALS & INTERFACES |
| Abstract | A wide range of biomedical devices are being used to treat cardiovascular diseases, and thus they routinely come into contact with blood. Insufficient hemocompatibility has been found to impair the functionality and safety of these devices through the activation of blood coagulation and the immune system. Numerous attempts have been made to develop surface modification approaches of the cardiovascular devices to improve their hemocompatibility. However, there are still no ideal "blood-friendly" coating materials, which possess the desired hemocompatibility, tissue compatibility, and mechanical properties. As a novel multifunctional material, graphene has been proposed for a wide range of biomedical applications. The chemical inertness, atomic smoothness, and high durability make graphene an ideal candidate as a surface coating material for implantable devices. Here, we evaluated the hemocompatibility of a graphene film prepared on quartz glasses (Gra-glasses) from a direct chemical vapor deposition process. We found that the graphene coating, which is free of transfer-mediating polymer contamination, significantly suppressed platelet adhesion and activation, prolonged coagulation time, and reduced ex vivo thrombosis formation. We attribute the excellent antithrombogenic properties of the Gra-glasses to the low surface roughness, low surface energy (especially the low polar component of the surface energy), and the negative surface charge of the graphene film. Given these excellent hemocompatible properties, along with its chemical inertness, high durability, and molecular impermeability, a graphene film holds great promise as an antithrombogenic coating for next-generation cardiovascular devices. |
| URI | http://hdl.handle.net/20.500.11897/604969 |
| ISSN | 1944-8244 |
| DOI | 10.1021/acsami.0c19790 |
| Indexed | EI SCI(E) |
| Appears in Collections: | 工学院 å å¦ä¸ å å å·¥ç¨ å¦é ¢ 前沿交叉学科研究院 物理学院 人工微结构和介观物理国家重点实验室 |
