| Title | mPFC GABAergic transmission mediated the role of BDNF signaling in cognitive impairment but not anxiety induced by adolescent social stress |
| Authors | Xu, Hang Wang, Jiesi Jing, Haiyang Ellenbroek, Bart Shao, Feng Wang, Weiwen |
| Affiliation | Inst Psychol, CAS Key Lab Mental Hlth, 16 Lincui Rd, Beijing 100101, Peoples R China Univ Chinese Acad Sci, Dept Psychol, Beijing, Peoples R China Victoria Univ Wellington, Sch Psychol, Wellington 6012, New Zealand Peking Univ, Sch Psychol & Cognit Sci, Beijing Key Lab Behav & Mental Hlth, Beijing, Peoples R China |
| Keywords | DEPRESSION INTERNEURONS BEHAVIOR TRKB TRANSCRIPTION NEURONS IMPACT COMORBIDITY ACTIVATION EXPRESSION |
| Issue Date | 15-Feb-2021 |
| Publisher | NEUROPHARMACOLOGY |
| Abstract | Depression with comorbid anxiety or cognitive symptoms can vary in terms of symptoms, pathophysiology and antidepressant efficacy, but the underlying neurobiological mechanisms remain to be elucidated. Previous studies from our group and others have shown that as a classic animal model of depression, adolescent social stress (ASS) could stably induce a variety of emotional and cognitive alterations in adult animals, and accompanied by transcriptional decrease in brain-derived neurotrophic factor (BDNF) total and promoter IV levels in the medial prefrontal cortex (mPFC). The present study further identified the GABAergic synaptic and molecular changes downstream of BDNF signaling impairment in the mPFC and roles in various behavioral phenotypes induced by ASS. We found that ASS induced a set of emotional and cognitive symptoms, including decreased social interest, impaired cognitive function, and increased anxiety-like behavior, as well as decreased GABAergic transmission in the mPFC. The specific deletion of BDNF promoter IV directly caused impairments in social interest, cognitive function, and inhibition of GABAergic transmission, but no changes in anxiety-like behavior. Acute microinjections of tropomyosin-related kinase B (TrkB) agonists into the mPFC and chronic antidepressant treatment ameliorated the changes in social behavior and cognition, as well as the reduction in GABAergic synaptic transmission in the mPFC, but not anxiety in previously stressed adult mice. These results suggest that the downstream GABAergic transmission of BDNF signaling in the mPFC involved in depression with comorbid cognitive dysfunction induced by ASS and can be used as a therapeutic target for the treatment of cognitive dysfunction in depression. This article is part of the special issue on Stress, Addiction and Plasticity. |
| URI | http://hdl.handle.net/20.500.11897/604709 |
| ISSN | 0028-3908 |
| DOI | 10.1016/j.neuropharm.2020.108412 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 心理与认知科学学院 行为与心理健康北京市重点实验室 |
