| Title | Longitudinal trajectory analysis of antipsychotic response in patients with schizophrenia: 6-week, randomised, open-label, multicentre clinical trial |
| Authors | Dai, Minhan Wu, Yulu Tang, Yiguo Yue, Weihua Yan, Hao Zhang, Yamin Tan, Liwen Deng, Wei Chen, Qi Yang, Guigang Lu, Tianlan Wang, Lifang Yang, Fude Zhang, Fuquan Yang, Jianli Li, Keqing Lv, Luxian Tan, Qingrong Zhang, Hongyan Ma, Xin Li, Lingjiang Wang, Chuanyue Ma, Xiaohong Zhang, Dai Yu, Hao Zhao, Liansheng Ren, Hongyan Wang, Yingcheng Hu, Xun Zhang, Guangya Du, Xiaodong Wang, Qiang Li, Tao |
| Affiliation | Sichuan Univ, West China Hosp, Mental Hlth Ctr, Chengdu, Peoples R China Sichuan Univ, West China Hosp, Psychiat Lab, Chengdu, Peoples R China Sichuan Univ, West China Hosp, West China Brain Res Ctr, Chengdu, Peoples R China Peking Univ Sixth Hosp, Inst Mental Hlth, Beijing, Peoples R China Peking Univ, Natl Clin Res Ctr Mental Disorders, Beijing, Peoples R China Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing, Peoples R China Cent South Univ, Xiangya Hosp 2, Changsha, Peoples R China Capital Med Univ, Inst Brain Disorders, Beijing Anding Hosp, Beijing, Peoples R China Beijing HuiLongGuan Hosp, Beijing, Peoples R China Nanjing Med Univ, Wuxi Mental Hlth Ctr, Nanjing, Peoples R China Tianjin Anding Hosp, Inst Mental Hlth, Tianjin, Peoples R China Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China Hebei Mental Hlth Ctr, Baoding, Peoples R China Xinxiang Med Univ, Affiliated Hosp 2, Urumqi, Peoples R China Fourth Mil Med Univ, Xijing Hosp, Dept Psychiat, Xian, Peoples R China Jining Med Univ, Dept Psychiat, Jining, Peoples R China Sichuan Univ, West China Hosp, Biobank, Chengdu, Peoples R China Soochow Univ, Affiliated Guangji Hosp, Suzhou Psychiat Hosp, Suzhou, Peoples R China |
| Keywords | SCALE PANSS RECOMMENDATIONS PREDICTORS MEDICATION |
| Issue Date | Nov-2020 |
| Publisher | BJPSYCH OPEN |
| Abstract | Background Understanding the patterns of treatment response is critical for the treatment of patients with schizophrenia; one way to achieve this is through using a longitudinal dynamic process study design. Aims This study aims to explore the response trajectory of antipsychotics and compare the treatment responses of seven different antipsychotics over 6 weeks in patients with schizoprenia (trial registration: Chinese Clinical Trials Registry Identifier: ChiCTR-TRC-10000934). Method Data were collected from a multicentre, randomised open-label clinical trial. Patients were evaluated with the Positive and Negative Syndrome Scale (PANSS) at baseline and follow-up at weeks 2, 4 and 6. Trajectory groups were classified by the method ofk-means cluster modelling for longitudinal data. Trajectory analyses were also employed for the seven antipsychotic groups. Results The early treatment response trajectories were classified into a high-trajectory group of better responders and a low-trajectory group of worse responders. The results of trajectory analysis showed differences compared with the classification method characterised by a 50% reduction in PANSS scores at week 6. A total of 349 patients were inconsistently grouped by the two methods, with a significant difference in the composition ratio of treatment response groups using these two methods (chi(2)= 43.37,P< 0.001). There was no differential contribution of high- and low trajectories to different drugs (chi(2)= 12.52,P= 0.051); olanzapine and risperidone, which had a larger proportion in the >50% reduction at week 6, performed better than aripiprazole, quetiapine, ziprasidone and perphenazine. Conclusions The trajectory analysis of treatment response to schizophrenia revealed two distinct trajectories. Comparing the treatment responses to different antipsychotics through longitudinal analysis may offer a new perspective for evaluating antipsychotics. |
| URI | http://hdl.handle.net/20.500.11897/593047 |
| ISSN | 2056-4724 |
| DOI | 10.1192/bjo.2020.105 |
| Indexed | SCI(E) SSCI |
| Appears in Collections: | 第六医院 |
