| Title | Immunomodulatory effects of walnut (Juglans regia L.) oligopeptides on innate and adaptive immune responses in mice |
| Authors | Mao, Ruixue Wu, Lan Zhu, Na Liu, Xinran Hao, Yuntao Liu, Rui Du, Qian Li, Yong |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Nutr & Food Hyg, Beijing 100191, Peoples R China Inner Mongolia Adm Market Regulat, Hohhot 010010, Peoples R China |
| Keywords | CELL RESPONSES TH CELLS PEPTIDES PROTEINS MODULATION |
| Issue Date | Oct-2020 |
| Publisher | JOURNAL OF FUNCTIONAL FOODS |
| Abstract | This study aimed to investigate the immunomodulatory effects of walnut (Juglans regia L.) oligopeptides (WOPs). Female BALB/c mice were randomly assigned to control, whey protein control and three WOPs groups, given deionized water, 220 mg/kg BW whey protein, 110, 220 and 440 mg/kg BW WOPs daily through drinking water for 30 days, respectively. The immonomodulatory activity determination of WOPs involved innate and adaptive immunity, spleen T lymphocyte subpopulations, serum cytokine and immunoglobulin levels. Our results showed that WOPs could significantly improve humoral and cell-mediated immune responses, macrophage phagocytosis and natural killer cell activity. Moreover, increased T and Th cells percentages, cytokines secretion of interleukin (IL)-2, IL-10, IL-12 and granulocyte-macrophage colony stimulating factor, and production of immunoglobulin (Ig)A, IgG, IgM and intestinally secreted IgA also contributed to these improvements. All these above indicated that WOPs could be a promising immunomodulatory dietary supplement at dosages ranging from 110 to 440 mg/kg BW. |
| URI | http://hdl.handle.net/20.500.11897/592941 |
| ISSN | 1756-4646 |
| DOI | 10.1016/j.jff.2020.104068 |
| Indexed | SCI(E) |
| Appears in Collections: | 公共卫生学院 |
