| Title | Aberrant resting-state cerebral blood flow and its connectivity in primary dysmenorrhea on arterial spin labeling MRI |
| Authors | Zhang, Ya-Nan Huang, Yi-Ran Liu, Jun-Lian Zhang, Feng-Quan Zhang, Bing-Yue Wu, Jun-Chen Ma, Ying Xia, Jing Hao, Ying Huo, Jian-Wei |
| Affiliation | Capital Med Univ, Beijing Hosp Tradit Chinese Med, Dept Radiol, 23 Meishuguanhou St, Beijing 100010, Peoples R China Beijing Univ Chinese Med, Sch Acupuncture Moxibust & Tuina, Beijing 100029, Peoples R China Henan Univ TCM, Affiliated Hosp 1, Tradit Chinese Med Ctr, Zhengzhou 453000, Henan, Peoples R China Yanshan Hosp, Acupuncture Dept, Beijing 102500, Peoples R China Peking Univ, Beijing Int Ctr Math Res, Yiheyuan Rd, Beijing 100871, Peoples R China |
| Keywords | FUNCTIONAL CONNECTIVITY DYNAMIC CHARACTERISTICS PAIN WOMEN CORTEX FMRI |
| Issue Date | Nov-2020 |
| Publisher | MAGNETIC RESONANCE IMAGING |
| Abstract | Purpose: This study aimed to clarify the resting-state cerebral blood flow alteration patterns induced by primary dysmenorrhea, investigate the relationships between cerebral blood flow alterations and clinical parameters of patients with primary dysmenorrhea, and explore whether brain regions with abnormal cerebral blood flow also feature functional connectivity changes. Methods: Arterial spin labeling imaging and clinical parameters were acquired in 42 patients with primary dysmenorrhea and 41 healthy controls during their menstrual phases. Differences in cerebral blood flow were compared between the two groups, and the clusters with significant group differences were selected as the regions of interest for further statistical analyses. Results: Compared to healthy controls, patients with primary dysmenorrhea exhibited increased cerebral blood flow in the bilateral precuneus, left posterior cingulate cortex, and right rolandic operculum. Among patients with primary dysmenorrhea, we identified a negative correlation between the cerebral blood flow in the right rolandic operculum and the visual analogue score for anxiety, and greater correlation between the functional connectivity in the precuneus/posterior cingulate cortex and the right middle cingulate cortex, and between the right rolandic operculum and the left inferior parietal lobule and the bilateral postcentral gyrus. Discussion: Cerebral blood flow abnormalities associated with primary dysmenorrhea were mainly concentrated in the areas comprising the default mode network in primary dysmenorrhea patients, which could be involved in the central mechanism of primary dysmenorrhea. Cerebral blood flow alteration in the rolandic operculum may underlie an anxiety-induced compulsive tendency in patients with primary dysmenorrhea. Investigating the enhanced connectivity among various pain-related brain regions could improve understanding of the onset and development of primary dysmenorrhea. |
| URI | http://hdl.handle.net/20.500.11897/592621 |
| ISSN | 0730-725X |
| DOI | 10.1016/j.mri.2020.07.012 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京国际数学研究中心 |
