| Title | AnnoLnc2: the one-stop portal to systematically annotate novel lncRNAs for human and mouse |
| Authors | Ke, Lan Yang, De-Chang Wang, Yu Ding, Yang Gao, Ge |
| Affiliation | Peking Univ, Sch Life Sci, Biomed Pioneering Innovat Ctr BIOPIC, Beijing 100871, Peoples R China Peking Univ, Beijing Adv Innovat Ctr Genom ICG, Ctr Bioinformat CBI, Beijing 100871, Peoples R China Peking Univ, State Key Lab Prot & Plant Gene Res, Beijing 100871, Peoples R China Beijing Inst Radiat Med, Beijing 100850, Peoples R China |
| Keywords | LONG NONCODING RNAS NUCLEAR-LOCALIZATION EXPRESSION EVOLUTION ELEMENTS DATABASE REVEALS |
| Issue Date | 2-Jul-2020 |
| Publisher | NUCLEIC ACIDS RESEARCH |
| Abstract | With the abundant mammalian lncRNAs identified recently, a comprehensive annotation resource for these novel lncRNAs is an urgent need. Since its first release in November 2016, AnnoLnc has been the only online server for comprehensively annotating novel human lncRNAs on-the-fly. Here, with significant updates to multiple annotation modules, backend datasets and the code base, AnnoLnc2 continues the effort to provide the scientific community with a one-stop online portal for systematically annotating novel human and mouse lncRNAs with a comprehensive functional spectrum covering sequences, structure, expression, regulation, genetic association and evolution. In response to numerous requests from multiple users, a standalone package is also provided for large-scale offline analysis. We believe that updated AnnoLnc2 (http://annolnc.gao-lab.org/) will help both computational and bench biologists identify lncRNA functions and investigate underlying mechanisms. |
| URI | http://hdl.handle.net/20.500.11897/591379 |
| ISSN | 0305-1048 |
| DOI | 10.1093/nar/gkaa368 |
| Indexed | SCI(E) |
| Appears in Collections: | 生命科学学院 其他实验室 |
