| Title | Comparison of the osteoblastic activity of low elastic modulus Ti-24Nb-4Zr-8Sn alloy and pure titanium modified by physical and chemical methods |
| Authors | Zhan, Xinxin Li, Shujun Cui, Yuntao Tao, Anqi Wang, Chengcheng Li, Huazhi Zhang, Linlin Yu, Hanrong Jiang, Jiuhui Li, Cuiying |
| Affiliation | Peking Univ, Sch & Hosp Stomatol, Dept Orthodont, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China Chinese Acad Sci, Inst Met Res, Titanium Alloy Lab, 72 Wenhua Rd, Shenyang 110016, Peoples R China Chinese Acad Sci, Tech Inst Phys & Chem, CAS Key Lab Cryogen & Beijing Key Lab Cryobiomed, Beijing 100190, Peoples R China Jiamusi Univ, Affiliated Stomatol, Dept Dent Implants, Jiamusi, Peoples R China Peking Univ, Sch & Hosp Stomatol, Cent Lab, 22 Zhongguancun South Ave, Beijing 100081, Peoples R China Natl Engn Lab Digital & Mat Technol Stomatol, Beijing, Peoples R China |
| Keywords | IMPLANT SURFACES CORROSION BEHAVIOR METALS DIFFERENTIATION OXIDATION CYTOCOMPATIBILITY PROLIFERATION ROUGHNESS ADHESION CELLS |
| Issue Date | Aug-2020 |
| Publisher | MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS |
| Abstract | Ti-24Nb-4Zr-8Sn (Ti2448) alloy is a novel low elastic modulus beta-titanium alloy without toxic elements. It also has the advantage of high strength, so it has potential application prospects for implantation. To develop its osteogenic effects, it can be modified by electrochemical, and physical processes. The main research aim of this study was to explore the bioactivity of Ti2448 alloy modified by sandblasted, large-grit, acid-etched (SLA), micro-arc oxidation (MAO) and anodic oxidation (AO), and to determine which of the three surface modifications is the best way for developing the osteogenesis of bone marrow mesenchymal stem cells (BMMSCs). In vitro studies, the cytoskeleton, focal adhesion and proliferation of BMMSCs showed that both pure titanium and Ti2448 alloy have good biocompatibility. The osteogenic differentiation of BMMSCs with the Ti2448 alloy were examined by detecting alkaline phosphatase (ALP), mineralization nodules and osteogenic proteins and were better than that with pure titanium. These results showed that the Ti2448 alloy treated by SLA has a better effect on osteogenesis than pure titanium, and AO is the best way of three surface treatments to improve osteogenesis in this study. |
| URI | http://hdl.handle.net/20.500.11897/589603 |
| ISSN | 0928-4931 |
| DOI | 10.1016/j.msec.2020.111018 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 口腔医院 |
