| Title | Are gene polymorphisms related to adverse events of methotrexate in patients with rheumatoid arthritis? A retrospective cohort study based on an updated meta-analysis |
| Authors | Huang, Jing Fan, Huizhen Qiu, Qi Liu, Kunpeng Lv, Shuang Li, Jiang Yang, Hui Shu, Xiaoming Xu, Yuan Lu, Xiangchen Lu, Cheng Zhang, Yunnan Xiao, Cheng |
| Affiliation | China Japan Friendship Hosp, Dept Emergency, Beijing, Peoples R China China Japan Friendship Hosp, Inst Clin Med, Beijing, Peoples R China Beijing Univ Chinese Med, Beijing, Peoples R China Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China Peoples Hosp Yichun, Dept Gastroenterol, Yichun, Jiangxi, Peoples R China Capital Med Univ, Beijing An Zhen Hosp, Inst Clin Pharmacol, Beijing, Peoples R China Peking Univ, Dept Anesthesiol, Int Hosp, Beijing, Peoples R China China Japan Friendship Hosp, Dept Lab Med, Beijing, Peoples R China China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China China Japan Friendship Hosp, Dept TCM Rheumatol, Beijing, Peoples R China China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing, Peoples R China |
| Keywords | SINGLE-NUCLEOTIDE POLYMORPHISMS MODIFYING ANTIRHEUMATIC DRUGS ABCB1 C3435T POLYMORPHISM THYMIDYLATE-SYNTHASE C677T POLYMORPHISM REDUCTASE GENE A1298C POLYMORPHISMS MTHFR POLYMORPHISMS TREATMENT RESPONSE FOLATE PATHWAY |
| Issue Date | Apr-2020 |
| Publisher | THERAPEUTIC ADVANCES IN CHRONIC DISEASE |
| Abstract | Aims: We performed an updated meta-analysis to verify correlations between gene polymorphisms and adverse events in methotrexate (MTX)-treated rheumatoid arthritis (RA) patients. Then, we conducted a retrospective cohort study of Han Chinese in China. Methods: Relevant studies were collected from the PubMed database and the EMBASE database until December 2017. Pre-allele, dominant, recessive, codominant, and homozygotic models were applied. In addition, a retrospective cohort study enrolling 162 RA patients treated with MTX was conducted. Single nucleotide polymorphism (SNP) genotyping was analyzed by PCR and product sequencing. Results: A total of 39 studies were included in 20 meta-analyses; meta-analysis showed a significant association between MTX-related toxicity and 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C>T(rs1801133) polymorphism in East Asian RA patients, and significant associations were observed between MTX-related toxicity and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase (ATIC) 347C>G (rs2372536), reduced folate carrier 1 (RFC-1) 80G>A (rs1051266), and adenosine triphosphate-binding cassette B1 (ABCB1) 3435C>T(rs1045642) polymorphisms in European RA patients but not in East Asian RA patients. Moreover, in our retrospective cohort study, ATIC 347C>G(rs2372536) and ABCB1 3435C>T(rs1045642) polymorphisms were not associated with MTX-related toxicity. However, a significant association was observed between MTX-related toxicity and RFC-1 80G>A (rs1051266) polymorphism in Chinese Han RA patients. Conclusion: Evidence-based results suggest that the MTHFR 677C>T(rs1801133), ATIC 347C>G(rs2372536), RFC-1 80G>A (rs1051266), ABCB1 3435C>T(rs1045642) polymorphisms are associated with MTX-related toxicity. Larger and more stringent study designs may provide more accurate findings for the effects of these SNPs on MTX-related toxicity, and larger sample-size studies of the Chinese Han population should be conducted for further validation. |
| URI | http://hdl.handle.net/20.500.11897/589320 |
| ISSN | 2040-6223 |
| DOI | 10.1177/2040622320916026 |
| Indexed | SCI(E) |
| Appears in Collections: | 国际医院 |
