| Title | IL1R2 Polymorphisms are Associated with Increased Risk of Esophageal Cancer |
| Authors | Liu, Jianfeng Yang, Yonghui Li, Haiyue Liu, Yuanwei Sun, Yao Wu, Jiamin Xiong, Zichao Jin, Tianbo |
| Affiliation | Northwest Univ, Sch Med, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, Xian 710069, Shaanxi, Peoples R China Xian 630 Hosp, Clin Lab, Xian 710089, Shaanxi, Peoples R China |
| Keywords | GENOME-WIDE ASSOCIATION SQUAMOUS-CELL CARCINOMA GENETIC POLYMORPHISMS INTERLEUKIN-1 VARIANTS RECEPTOR SUSCEPTIBILITY IL-1R2 CHINA |
| Issue Date | 2020 |
| Publisher | CURRENT MOLECULAR MEDICINE |
| Abstract | Background: Esophageal cancer (EC) is the sixth leading cause of cancer death worldwide, and the overall incidence is increasing. Objective: The aim of this study was to evaluate the association between single nucleotide polymorphisms in IL1R2 and EC risk in the Chinese population. Methods: Genotyping of six SNPs of IL1R2 was performed with the Agena MassARRAY platform from 384 EC and 499 controls. The association between polymorphisms and EC risk was assessed by performing genetics models and haplotype analyses. Results: Overall analysis results showed that the allele C of rs11674595 (odds ratio [OR] = 1.42, 95% confidence interval [CI]: 1.14-1.77, p = 0.002) and allele G of rs2072472 (allele: OR = 1.35, 95% CI: 1.08-1.69, p = 0.008) were associated with an increased EC risk. The rs11674595 and rs2072472 were found to be correlated with EC risk under the codominant, dominant, and additive models. Stratification analysis found that rs11674595 and rs2072472 were associated with increased EC risk in male and in age > 55 years old subgroup. In addition, C(rs11674595)G(rs4851527) haplotype was significantly associated with 1.44-fold increased risk of EC (95% CI: 1.12-1.84, p = 0.004). Conclusion: Our results reveal the significant association between SNPs (rs11674595 and rs2072472) in the IL1R2 and EC risk in the Chinese Han population. The findings may provide meaningful reference for the prevention and treatment of EC. |
| URI | http://hdl.handle.net/20.500.11897/588653 |
| ISSN | 1566-5240 |
| DOI | 10.2174/1566524019666191025091204 |
| Indexed | SCI(E) |
| Appears in Collections: | 待认领 |
