| Title | Metabolic linkages between indoor negative air ions, particulate matter and cardiorespiratory function: A randomized, double-blind crossover study among children |
| Authors | Liu, Shan Huang, Qingyu Wu, Yan Song, Yi Dong, Wei Chu, Mengtian Yang, Di Zhang, Xi Zhang, Jie Chen, Chen Zhao, Bin Shen, Heqing Guo, Xinbiao Deng, Furong |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China Chinese Acad Sci, Inst Urban Environm, Key Lab Urban Environm & Hlth, Xiamen 361021, Peoples R China Peking Univ, Inst Child & Adolescent Hlth, Sch Publ Hlth, Beijing 100191, Peoples R China Xiamen Univ, Sch Publ Hlth, State Key Lab Mol Vaccinol & Mol Diagnost, 4221-117 Xiang An Nan Rd, Xiamen 361102, Peoples R China Tsinghua Univ, Sch Architecture, Dept Bldg Sci, Beijing 100084, Peoples R China |
| Keywords | AUTONOMIC FUNCTION BLACK CARBON EXPOSURE HEALTH ASSOCIATION CLEANERS INFLAMMATION VARIABILITY INHIBITION DEFICIENCY |
| Issue Date | May-2020 |
| Publisher | ENVIRONMENT INTERNATIONAL |
| Abstract | Background: Ionization air purifiers, which purify particulate matter (PM) by producing vast number of negative air ions (NAI), are widely used. Recent study implied that ionization air purification could bring respiratory benefits but deterioration of heart rate variability (HRV). However, its underlying molecular mechanisms remain unclear. Objectives: To explore the molecular linkages between indoor NAI, decreased PM and the cardiorespiratory effect after purification. Methods: Urine samples were collected from 44 healthy children three times of each study period (real and sham purification) in an existing randomized, double-blind crossover study. Ultra-high performance liquid chromatography/mass spectrometry was conducted in metabolomics analysis, the associations between indoor NAI, decreased PM and the cardiorespiratory function were investigated via the meet-in-metabolite approach (MIMA) based on statistical and metabolic pathway analysis. Mixed-effect models were used to establish associations between exposure, health parameters and metabolites. Results: Twenty-eight and fourteen metabolites were identified with significant correlations to NAI and PM, respectively. Besides, eight and eighteen metabolites were separately associated with respiratory function and HRV. The increased NAI and decreased PM improved respiratory function mainly with eight pathways, promoting energy production, anti-inflammation and anti-oxidation capacity. Decreased PM ameliorated HRV with six main pathways, increasing energy production and anti-inflammation capacity while increased NAI deteriorated HRV with five main pathways, lowering energy generation and anti-oxidation capacity. Conclusions: Increased NAI and decreased PM ameliorated respiratory function by increasing energy production, improving anti-inflammation and anti-oxidation capacity. Decreased PM improved cardiac autonomic function by increasing energy production and anti-inflammation capacity, while these benefits were overcast by massive NAI via lowering energy generation and anti-oxidation capacity with different metabolic pathways. |
| URI | http://hdl.handle.net/20.500.11897/587490 |
| ISSN | 0160-4120 |
| DOI | 10.1016/j.envint.2020.105663 |
| Indexed | SCI(E) Scopus EI |
| Appears in Collections: | 公共卫生学院 |
