| Title | The safety and feasibility of intraoperative near-infrared fluorescence imaging with indocyanine green in thoracoscopic sympathectomy for primary palmar hyperhidrosis |
| Authors | Pei, Guotian Liu, Yanguo Liu, Qiang Min, Xianjun Yang, Yingshun Wang, Shuai Liu, Jun Wang, Jun Huang, Yuqing |
| Affiliation | Peking Univ, Dept Thorac Surg, Haidian Sect, Beijing Haidian Hosp,Hosp 3, 29 Zhongguancun St, Beijing 100080, Peoples R China Peking Univ, Dept Thorac Surg, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China |
| Keywords | ADVERSE-REACTIONS CLINICAL-APPLICATION TRIAL DYE |
| Issue Date | Apr-2020 |
| Publisher | THORACIC CANCER |
| Abstract | Background We investigated the safety and feasibility of intraoperative near-infrared (NIR) imaging using indocyanine green (ICG) during sympathectomy in the management of primary palmar hyperhidrosis (PPH). Methods We performed a retrospective review of 142 patients (ICG group) who underwent endoscopic thoracic sympathectomy (ETS) between February 2018 and April 2019. All patients received a 5 mg/kg infusion of ICG 24 hours preoperatively. The vital signs before and after ICG injection and adverse reactions were recorded. Meanwhile, 498 patients (Non-ICG group) who underwent ETS by normal thoracoscopy during August 2017 to April 2019 were also reviewed to compare the abnormal white blood cell (WBC) counts, alanine transaminase (ALT), aspartate transaminase (AST), blood urea nitrogen (BUN), and creatinine (Cr) levels before and after operation between two groups. Results For ICG group, the vital signs including body temperature, heart rate and blood pressure before and after ICG injection were stable. There was no significant difference in the abnormal WBC counts, ALT, AST, BUN, and Cr levels before and after operation between two groups. Only one patient had mild adverse reaction (0.7%) after ICG injection. The visibility rate of all sympathetic ganglions was 96.7% (1369/1415). The visibility rate from T1 to T5 was 98.23% (278/283), 98.23% (278/283), 97.17% (275/283), 95.76% (271/283), and 94.35% (267/283), respectively. There was no significant difference in the visibility rate with regard to age, gender, height, weight, body mass index, and PPH grade. Conclusions NIR fluorescence imaging with ICG for identifying sympathetic ganglions is relatively safe and feasible. Key points center dot Significant findings of the study. NIR fluorescence imaging with ICG for identifying sympathetic ganglions is relatively safe and feasible. center dot What this study adds. This technology may take the place of the rib-oriented method as standard practice for the precise localization of sympathetic ganglions, and may improve the effect of sympathectomies. |
| URI | http://hdl.handle.net/20.500.11897/587457 |
| ISSN | 1759-7706 |
| DOI | 10.1111/1759-7714.13345 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 人民医院 |
