| Title | Genetic risk, adherence to a healthy lifestyle, and type 2 diabetes risk among 550,000 Chinese adults: results from 2 independent Asian cohorts |
| Authors | Li, Haoxin Khor, Chiea-Chuen Fan, Junning Lv, Jun Yu, Canqing Guo, Yu Bian, Zheng Yang, Ling Millwood, Iona Y. Walters, Robin G. Chen, Yiping Yuan, Jian-Min Yang, Yan Hu, Chen Chen, Junshi Chen, Zhengming Koh, Woon-Puay Huang, Tao Li, Liming |
| Affiliation | Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Hlth Sci Ctr, Beijing, Peoples R China Genome Inst Singapore, Singapore, Singapore Singapore Eye Res Inst, Singapore, Singapore Peking Univ, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing, Peoples R China Peking Univ, Inst Environm Med, Beijing, Peoples R China Chinese Acad Med Sci, Beijing, Peoples R China Univ Oxford, Nuffield Dept Populat Hlth, Clin Trial Serv Unit, Oxford, England Univ Oxford, Nuffield Dept Populat Hlth, Epidemiol Studies Unit, Oxford, England Univ Pittsburgh, Div Canc Control & Populat Sci, Canc Inst, Pittsburgh, PA USA Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA 15260 USA Huixian Peoples Hosp, Huixian, Henan, Peoples R China Huixian CDC, NCDs Prevent & Control Dept, Huixian, Henan, Peoples R China China Natl Ctr Food Safety Risk Assessment, Beijing, Peoples R China Duke NUS Med Sch, Hlth Serv & Syst Res, Singapore, Singapore Natl Univ Singapore, Saw Swee Hock Sch Publ Hlth, Singapore, Singapore |
| Keywords | BODY-MASS INDEX MENDELIAN RANDOMIZATION PREVALENCE VARIANTS SMOKING PATTERN TRAITS WOMEN MEN |
| Issue Date | Mar-2020 |
| Publisher | AMERICAN JOURNAL OF CLINICAL NUTRITION |
| Abstract | Background: Whether genetic susceptibility to type 2 diabetes is modified by a healthy lifestyle among Chinese remains unknown. Objectives: The aim of the study was to determine whether genetic risk and adherence to a healthy lifestyle contribute independently to the risk of developing type 2 diabetes. Methods: We defined a lifestyle score using BMI, alcohol intake, smoking, physical activities, and diets in 461,030 participants from the China Kadoorie Biobank and 38,434 participants from the Singapore Chinese Health Study. A genetic risk score was constructed based on type 2 diabetes loci among 100,175 and 16,172 participants in each cohort, respectively. A Cox proportional-hazards model was used to estimate the interaction between genetic and lifestyle factors on the risk of type 2 diabetes. Results: In 2 independent Asian cohorts, we consistently found a healthy lifestyle (the bottom quintile of lifestyle score) was associated with a substantially lower risk of type 2 diabetes than an unhealthy lifestyle (the top quintile of lifestyle score) regardless of genetic risk. In those at a high genetic risk, the risk of type 2 diabetes was 57% lower among participants with a healthy lifestyle than among those with an unhealthy lifestyle in the pooled cohorts. Among participants at high genetic risk, the standardized 10-y incidence of type 2 diabetes was 7.11% in those with an unhealthy lifestyle vs. 2.45% in those with a healthy lifestyle. Conclusions: In 2 independent cohorts involving 558,302 Chinese participants, we did not observe an interaction between genetics and lifestyle with type 2 diabetes risk, but our findings provide replicable evidence to show lifestyle factors and genetic factors were independently associated with the risk of type 2 diabetes. Within any genetic risk category, a healthy lifestyle was associated with a significantly lower risk of type 2 diabetes among the Chinese population. |
| URI | http://hdl.handle.net/20.500.11897/586749 |
| ISSN | 0002-9165 |
| DOI | 10.1093/ajcn/nqz310 |
| Indexed | SCI(E) Scopus |
| Appears in Collections: | 公共卫生学院 分子心血管学教育部重点实验室 |
