| Title | One-year all-cause mortality risk among atrial fibrillation patients in Middle East with and without diabetes: The Gulf SAFE registry |
| Authors | Domek, Magdalena Li, Yan-Guang Gumprecht, Jakub Asaad, Nidal Rashed, Wafa Alsheikh-Ali, Alawi Nabrdalik, Katarzyna Gumprecht, Janusz Zubaid, Mohammad Lip, Gregory Y. H. |
| Affiliation | Univ Liverpool, Liverpool Ctr Cardiovasc Sci, Liverpool, Merseyside, England Liverpool Heart & Chest Hosp, Liverpool, Merseyside, England Aalborg Univ, Aalborg Thrombosis Res Unit, Dept Clin Med, Aalborg, Denmark Silesian Med Univ, Silesian Ctr Heart Dis, Dept Cardiol Congenital Heart Dis & Electrotherap, Zabrze, Poland Silesian Med Univ, Dept Internal Dis Diabetol & Nephrol, Zabrze, Poland Peking Univ, Dept Cardiol, Hosp 3, Beijing, Peoples R China Hamad Med Corp, Cardiol Dept, Heart Hosp, Doha, Qatar Mubarak Al Kabeer Hosp, Dept Med, Jabriya, Kuwait Mubarak Al Kabeer Hosp, Div Cardiol, Jabriya, Kuwait Mohammed Bin Rashid Univ Med & Hlth Sci, Coll Med, Dubai, U Arab Emirates |
| Keywords | EURO HEART SURVEY PREDICTING STROKE KIDNEY-DISEASE METAANALYSIS PREVALENCE OUTCOMES COHORT COUNTRIES MELLITUS IMPACT |
| Issue Date | 1-Mar-2020 |
| Publisher | INTERNATIONAL JOURNAL OF CARDIOLOGY |
| Abstract | Background: Atrial fibrillation (AF) poses a great risk of mortality, especially when associated with diabetes mellitus (DM). Objectives: We aimed to investigate the rate and risk factors for mortality among AF patients with and without DM in the population from the Middle East where it has never been investigated before. Methods: We analyzed the Gulf-SAFE registry, involving patients with nonvalvular AF from the Middle East, for one-year all-cause mortality. The predictive capability of the CHA(2)DS(2)-VASc score for death was also investigated. Results: Among a total of 2043 AF patients 606 had DM. Patients with DM were older and had significantly higher prevalence of multiple comorbidities (p < 0.05, respectively). Among patients with DM, age >= 75 (relative risk 2.34, 95% confidence interval 1.19-4.61), heart failure (HF) (RR 2.14, 95%CI 1.03-4.43), peripheral vascular disease (PVD) (RR 3.36, 95%CI 1.22-9.30) and chronic kidney disease (CKD) (RR 2.60, 95%CI 1.16-5.81) were independent risk factors for one year all-cause mortality. Patients with DM had significantly higher rates of heart failure and AF-related hospital admissions, all-cause mortality and composite outcome rates, in one year follow up. Among patients with DM, the CHA2DS2-VASc score was predictive of one-year all-cause mortality with c-index of 0.741 (95%CI 0.688-0.794). Conclusions: AF patients in Middle East with DM have a higher risk for all-cause mortality, HF and AF admission and composite outcome, compared to patients without DM. Multiple risk factors contribute to the higher mortality rate among patients with DM. (C) 2020 Elsevier B.V. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/585780 |
| ISSN | 0167-5273 |
| DOI | 10.1016/j.ijcard.2019.12.061 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
