| Title | Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata |
| Authors | Li, Bin Kuang, Yi He, Jun-Bin Tang, Rui Xu, Lu-Lu Leung, Chung-Hang Ma, Dik-Lung Qiao, Xue Ye, Min |
| Affiliation | Peking Univ, Sch Pharmaceut Sci, Minist Educ, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China Peking Univ, Sch Pharmaceut Sci, Minist Educ, Key Lab Mol Cardiovasc Sci, 38 Xueyuan Rd, Beijing 100191, Peoples R China Univ Macau, State Key Lab Qual Res Chinese Med, Inst Chinese Med Sci, Macau, Peoples R China Hong Kong Baptist Univ, Dept Chem, Kowloon Tong, SWT 802, Hong Kong, Peoples R China |
| Keywords | OXIDATIVE STRESS ANTIINFLAMMATORY TRITERPENOIDS LIVER-INJURY BIOSYNTHESIS DISRUPTION |
| Issue Date | Jan-2020 |
| Publisher | JOURNAL OF NATURAL PRODUCTS |
| Abstract | Antrodia camphorata is a rare and valuable medicinal mushroom. In this work, 11 new triterpenoids, namely, antcamphorols A-K (1-11), together with 10 known triterpenoids, 12-21, were isolated from dish-cultured A. camphorata. Compound 1 is an unprecedented C31 lanostane-type triterpenoid featuring a methyl group at C-15 and a C-21-O-C-24 tetrahydropyran ring at C-17. Compounds 2-11 are ergostane-type triterpenoids, and they include two pairs of norergostanes 2-5. The structures of the new compounds were identified by NMR, 2D NMR, and HRESIMS data analyses. The absolute configurations of 1 and 6 were defined by X-ray diffraction data, and the absolute configuration at C-25 of 4 was determined by the modified Moshers method. Compounds 7, 9, 10, 16, and 19 showed significant ROS scavenging activities (63.9-70.5% at 20 mu M) in high-glucose-induced HUVECs. Compounds 3 and 8 exhibited moderate cytotoxic activities against U251 (IC50, 9.2 mu M) and MCF-7 (IC50, 8.1 mu M) human cancer cell lines, respectively. |
| URI | http://hdl.handle.net/20.500.11897/585664 |
| ISSN | 0163-3864 |
| DOI | 10.1021/acs.jnatprod.9b00580 |
| Indexed | IC SCI(E) Scopus |
| Appears in Collections: | 药学院 天然药物与仿生药物国家重点实验室 |
