| Title | Albuminuria and other target organ damage in Chinese patients with hypertension and diabetes: A data analysis based on the ATTEND study |
| Authors | Ren, Qian Ma, Changsheng Wang, Jiguang Guo, Xiaohui Ji, Linong |
| Affiliation | Peking Univ, Dept Endocrinol & Metab, Peoples Hosp, 11 Xizhimen South St, Beijing 100044, Peoples R China Capital Med Univ, Beijing Anzhen Hosp, Dept Cardiol, Beijing, Peoples R China Shanghai Jiao Tong Univ, Shanghai Key Lab Hypertens, Ctr Epidemiol Studies & Clin Trials, Shanghai Inst Hypertens,Sch Med,Ruijin Hosp,Dept, Shanghai, Peoples R China Peking Univ, Dept Endocrinol, Hosp 1, Beijing, Peoples R China |
| Keywords | LEFT-VENTRICULAR HYPERTROPHY CORONARY-HEART-DISEASE BLOOD-PRESSURE RENAL-FUNCTION CARDIOVASCULAR-DISEASE RISK-FACTORS MICROALBUMINURIA ASSOCIATION MELLITUS PREVALENCE |
| Issue Date | Jan-2020 |
| Publisher | JOURNAL OF DIABETES AND ITS COMPLICATIONS |
| Abstract | Aims: The relationship between albuminuria and left ventricular hypertrophy (LVH) was well characterized in hypertension (HTN), but not in diabetes. Moreover, most studies have described the correlation between albuminuria and cardiovascular mortality, but not cardiovascular diseases (CVD) morbidity. This study aimed to explore the relationship between albuminuria and LVH, CVD morbidity in patients with HTN, diabetes mellitus (DM) or HTN + DM. Methods: Conducted a data analysis based on the demographic, medical history and laboratory data of 2504 patients from the ATTEND study, a national registry study on HTN and DM in Chinese outpatients. Results: The prevalence of LVH and CVD was 7.7% and 21.5% in HTN + DM, 7.6% and 17.6% in HTN, 3.9% and 5.2% in DM patients. Subjects with HTN + DM implied higher risk of LVH (P = 0.023), CVD (P = 0.001) and 10-year coronary heart disease (CHD) (P < 0.001) than those with DM only. There was no significant relationship between albuminuria and LVH or CVD. Conclusions: More than one-fifth of HTN and/or DM patients with microalbuminuria suffered from CVD. Comorbidity of DM and HTN significantly increases cardiovascular events than DM only. No statistical association between albuminuria and LVH or CVD was found. (C) 2019 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/585411 |
| ISSN | 1056-8727 |
| DOI | 10.1016/j.jdiacomp.2019.107470 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 第一医院 |
