| Title | Concise review: Pulp stem cells derived from human permanent and deciduous teeth: Biological characteristics and therapeutic applications |
| Authors | Shi, Xin Mao, Jing Liu, Yan |
| Affiliation | Huazhong Univ Sci & Technol, Tongji Hosp, Ctr Stomatol, Tongji Med Coll, 1095 Jiefang Ave, Wuhan 430030, Peoples R China Peking Univ, Dept Orthodont, Lab Biomimet Nanomat, Sch & Hosp Stomatol, Beijing, Peoples R China |
| Keywords | HUMAN DENTAL-PULP SHOW MULTIFACETED BENEFITS FIBROBLAST-GROWTH-FACTOR DE-NOVO REGENERATION SPINAL-CORD-INJURY FUNCTIONAL RECOVERY IN-VITRO CORNEAL EPITHELIUM CONDITIONED MEDIUM MATRIX COMPONENTS |
| Issue Date | Apr-2020 |
| Publisher | STEM CELLS TRANSLATIONAL MEDICINE |
| Abstract | Human pulp stem cells (PSCs) include dental pulp stem cells (DPSCs) isolated from dental pulp tissues of human extracted permanent teeth and stem cells from human exfoliated deciduous teeth (SHED). Depending on their multipotency and sensitivity to local paracrine activity, DPSCs and SHED exert therapeutic applications at multiple levels beyond the scope of the stomatognathic system. This review is specifically concentrated on PSC updated biological characteristics and their promising therapeutic applications in (pre)clinical practice. Biologically, distinguished from conventional mesenchymal stem cell markers in vitro, NG2, Gli1, and Celsr1 have been evidenced as PSC markers in vivo. Both perivascular cells and glial cells account for PSC origin. Therapeutically, endodontic regeneration is where PSCs hold the most promises, attributable of PSCs' robust angiogenic, neurogenic, and odontogenic capabilities. More recently, the interplay between cell homing and liberated growth factors from dentin matrix has endowed a novel approach for pulp-dentin complex regeneration. In addition, PSC transplantation for extraoral tissue repair and regeneration has achieved immense progress, following their multipotential differentiation and paracrine mechanism. Accordingly, PSC banking is undergoing extensively with the intent of advancing tissue engineering, disease remodeling, and (pre)clinical treatments. |
| URI | http://hdl.handle.net/20.500.11897/585257 |
| ISSN | 2157-6564 |
| DOI | 10.1002/sctm.19-0398 |
| Indexed | SCI(E) |
| Appears in Collections: | 口腔医院 |
