| Title | Novel Plasmid-Mediated tet(X5) Gene Conferring Resistance to Tigecycline, Eravacycline, and Omadacycline in a Clinical Acinetobacter baumannii Isolate |
| Authors | Wang, Liyuan Liu, Dejun Lv, Yuan Cui, Lanqing Li, Yun Li, Tianmeng Song, Huangwei Hao, Yuxin Shen, Jianzhong Wang, Yang Walsh, Timothy R. |
| Affiliation | Peking Univ, Inst Clin Pharmacol, Hosp 1, Beijing, Peoples R China China Agr Univ, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Coll Vet Med, Beijing, Peoples R China Inst Infect & Immun, Dept Med Microbiol & Infect Dis, Cardiff, S Glam, Wales |
| Keywords | TETX |
| Issue Date | Jan-2020 |
| Publisher | ANTIMICROBIAL AGENTS AND CHEMOTHERAPY |
| Abstract | A novel, plasmid-mediated, high-level tigecycline resistance tet(X) gene variant, tet(X5), was detected in a clinical Acinetobacter baumannii isolate from China in 2017. Tet(X5) shows 84.5% and 90.5% amino acid identity to Tet(X3) and Tet(X4), respectively, with similar binding sites and a comparable affinity for tetracyclines. The tet(X5)-containing plasmid could only be transferred to A. baumannii via electro-transformation. This report follows the recent study describing the identification of tet(X3) and tet(X4). |
| URI | http://hdl.handle.net/20.500.11897/585026 |
| ISSN | 0066-4804 |
| DOI | 10.1128/AAC.01326-19 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
