| Title | Synthesis and Thermoresponsive Properties of Biocompatible and Biodegradable Triblock Copolymers Bearing Linear or Y-Shaped OEG Pendants |
| Authors | He, Xiongliang Wang, Xiaodan Zhou, Rongtao Lu, Hua Luan, Shifang Tang, Haoyu |
| Affiliation | Xiangtan Univ, Key Lab Polymer Mat & Applicat Technol Hunan Prov, Coll Chem, Xiangtan 411105, Peoples R China Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Jilin, Peoples R China Peking Univ, Beijing Natl Lab Mol Sci, Ctr Soft Matter Sci & Engn, Key Lab Polymer Chem & Phys,Minist Educ,Coll Chem, Beijing 100871, Peoples R China Soochow Univ, Inst Funct Nano & Soft Mat FUNSOM, Suzhou 215123, Peoples R China |
| Keywords | CRITICAL SOLUTION TEMPERATURE RESPONSIVE POLY(L-GLUTAMATE) PHASE-BEHAVIOR SIDE-CHAIN POLYMERS POLYPEPTIDE LCST UCST POLY(2-OXAZOLINE)S DRUG |
| Issue Date | Feb-2020 |
| Publisher | MACROMOLECULAR CHEMISTRY AND PHYSICS |
| Abstract | Biocompatible and biodegradable thermoresponsive polymers are of great interest in "smart" biomedical applications. Herein, triblock copolymers (6a and 6b) comprised of hydrophobic poly(propylene glycol) (PPG) and OEGylated polypeptides bearing Y-shaped or linear pendants are prepared by ring-opening polymerization of reactive N-carboxyanhydride monomers and subsequent side chain modification of polypeptides. OEGylated triblock copolymer bearing Y-shaped (6a) or linear pendants (6b) with similar main chain length and the same amount of oligo(ethylene glycol) (OEG) units are successfully prepared as verified by H-1 NMR, FTIR, and GPC. CD analysis reveals that 6a with Y-shaped OEG pendants shows thermal- or salt-induced destabilization of alpha-helical conformation in water. Both 6a and 6b show reversible lower critical solution temperature (LCST)-type phase transitions in DI H2O or PBS. Incorporation of a PPG segment leads to a significant decrease of the LCST-type cloud point temperature (T-cp). Consequently, 6a and 6b show T-cp to human body temperature at low polymer concentrations (<= 0.5 mg mL(-1) in PBS). Moreover, 6a and 6b show low in vitro cytotoxicity and biodegradability in the presence of proteinase K. The results indicate that the thermoresponsive properties of LCST-type polymers can be readily tuned by constructing Y-shaped pendants as well as incorporation of hydrophobic polymer building blocks. |
| URI | http://hdl.handle.net/20.500.11897/584981 |
| ISSN | 1022-1352 |
| DOI | 10.1002/macp.201900421 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 化学与分子工程学院 高分子化学与物理教育部重点实验室 |
