| Title | Emerging roles of non-coding RNAs in scoliosis |
| Authors | Li, Zheng Li, Xingye Shen, Jianxiong Zhang, Lin Chan, Matthew T. V. Wu, William K. K. |
| Affiliation | Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Orthopaed Surg, Beijing, Peoples R China Tsinghua Univ, Peking Univ, Beijing Jishuitan Hosp, Dept Orthoped Surg,Jishuitan Orthopaed Coll,Clin, Beijing, Peoples R China Chinese Univ Hong Kong, Dept Anaesthesia & Intens Care, Hong Kong, Peoples R China Chinese Univ Hong Kong, Inst Digest Dis, Ctr Gut Microbiota Res, State Key Lab Digest Dis, Hong Kong, Peoples R China Chinese Univ Hong Kong, LKS Inst Hlth Sci, Hong Kong, Peoples R China |
| Keywords | GENE PROLIFERATION PROGRESSION EXPRESSION MICRORNA METHYLATION PATHWAY MODELS CANCER |
| Issue Date | Feb-2020 |
| Publisher | CELL PROLIFERATION |
| Abstract | Scoliosis, a complex three-dimensional deformity of the spine with the Cobb angle (a measure of the spinal lateral curvature) >10 degree, encompasses a spectrum of pathologies, including congenital, idiopathic, syndromic and neuromuscular aetiologies. The pathogenesis is multifactorial involving both environmental and genetic factors but the exact cellular and molecular mechanisms of disease development remain largely unknown. Emerging evidence showed that non-coding RNAs (ncRNAs), namely microRNAs, long ncRNAs and circular RNAs, are deregulated in many orthopaedic diseases, including scoliosis. Importantly, these deregulated ncRNAs functionally participate in the initiation and progression of scoliosis. Here, we review recent progress in ncRNA research on scoliosis. |
| URI | http://hdl.handle.net/20.500.11897/584924 |
| ISSN | 0960-7722 |
| DOI | 10.1111/cpr.12736 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京积水潭医院 |
