| Title | Pd@Au Bimetallic Nanoplates Decorated Mesoporous MnO2 for Synergistic Nucleus-Targeted NIR-II Photothermal and Hypoxia-Relieved Photodynamic Therapy |
| Authors | Zhang, Yiyi Lv, Fan Cheng, Yaru Yuan, Zhipeng Yang, Fan Liu, Conghui Cao, Yu Zhang, Kai Lu, Huiting Zada, Shah Guo, Shaojun Dong, Haifeng Zhang, Xueji |
| Affiliation | Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Res Ctr Bioengn & Sensing Technol, Beijing Key Lab Bioengn & Sensing Technol, 30 Xueyuan Rd, Beijing 100083, Peoples R China Peking Univ, Coll Engn, Dept Mat Sci & Engn, Beijing 100871, Peoples R China Peking Univ, BIC ESAT, Coll Engn, Beijing 100871, Peoples R China |
| Keywords | NANOPARTICLES GOLD ABSORPTION NANOSHEETS SIZE |
| Issue Date | Jan-2020 |
| Publisher | ADVANCED HEALTHCARE MATERIALS |
| Abstract | Bimetallic nanoparticles have received considerable attention owing to synergistic effect and their multifunctionality. Herein, new multifunctional Pd@Au bimetallic nanoplates decorated hollow mesoporous MnO2 nanoplates (H-MnO2) are demonstrated for achieving not only nucleus-targeted NIR-II photothermal therapy (PTT), but also tumor microenvironment (TME) hypoxia relief enhanced photodynamic therapy (PDT). The Pd@Au nanoplates present a photothermal conversion efficiency (PTCE) as high as 56.9%, superior to those PTAs activated in the NIR-II region such as Cu9S5 nanoparticles (37%), Cu3BiS3 nanorods (40.7%), and Au/Cu2-xS nanocrystals (43.2%). They further functionalize with transactivator of transcription (TAT) moiety for cell nuclear-targeting and biodegradable hollow mesoporous MnO2 (approximate to 100 nm) loaded with photosensitizer Ce6 (TAT-Pd@Au/Ce6/PAH/H-MnO2) to construct a hierarchical targeting nanoplatform. The as-made TAT-Pd@Au/Ce6/PAH/H-MnO2 demonstrates good premature renal clearance escape ability and increased tumor tissue accumulation. It can be degraded in acidic TME and generate O-2 by reacting to endogenous H2O2 to relieve the hypoxia for enhanced PDT, while the released small TAT-Pd@Au nanoplates can effectively enter into the nucleus to mediate PTT. As a result, a remarkable therapeutic effect is achieved owing to the synergistic PTT/PDT therapy. This hierarchical targeting, TME-responsive, cytoplasm hypoxia relief PDT, and nuclear NIR-II PTT synergistic therapy can pave a new avenue for nanomaterials-based cancer therapy. |
| URI | http://hdl.handle.net/20.500.11897/584918 |
| ISSN | 2192-2640 |
| DOI | 10.1002/adhm.201901528 |
| Indexed | SCI(E) Scopus EI |
| Appears in Collections: | 工学院 |
