| Title | Abdominal circumference profiles of macrosomic infants born to mothers with or without hyperglycemia in China |
| Authors | Yan, Jie Yang, Huixia Meng, Wenying Wang, Yongqing Shang, Lixin Cai, Zhenyu Ji, Liping Wang, Yunfeng Sun, Ying Liu, Jiaxiu Wei, Li Sun, Yufeng Zhang, Xueying Luo, Tianxia Chen, Haixia Yu, Lijun Liu, Xinghui Wang, Zilian Chen, Haitian |
| Affiliation | Peking Univ, Dept Obstet & Gynecol, Hosp 1, Xianmen St 1, Beijing 100034, Peoples R China Tongzhou Maternal & Child Hlth Hosp Beijing, Dept Obstet & Gynecol, Beijing, Peoples R China Peking Univ, Dept Obstet & Gynecol, Hosp 3, Beijing, Peoples R China Gen Hosp Beijing Mil Reg, Dept Obstet & Gynecol, Beijing, Peoples R China Ctr Hosp Aviat Ind, Dept Obstet & Gynecol, Beijing, Peoples R China Pinggu Maternal & Child Hlth Hosp Beijing, Dept Obstet & Gynecol, Beijing, Peoples R China Beijing Hosp Miyun City, Dept Obstet & Gynecol, Beijing, Peoples R China Navy Gen Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China Beijing Daxing Dist Hongxing Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China Beijing Chui Yang Liu Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China Peking Univ, Dept Obstet & Gynecol, Shougang Hosp, Beijing, Peoples R China Combined Tradit Chinese & Western Med Hosp Beijin, Dept Obstet & Gynecol, Beijing, Peoples R China Beijing 6 Hosp, Dept Obstet & Gynecol, Beijing, Peoples R China Beijing Changping Hosp Tradit Chinese Med, Dept Obstet & Gynecol, Beijing, Peoples R China Gen Hosp Jingmei Grp, Dept Obstet & Gynecol, Beijing, Peoples R China West China Second Univ Hosp, Dept Obstet & Gynecol, Chengdu, Sichuan, Peoples R China Sun Yat Sen Univ, Affiliated Hosp 1, Dept Obstet & Gynecol, Guangzhou, Guangdong, Peoples R China |
| Keywords | GESTATIONAL DIABETES-MELLITUS ACCELERATED FETAL-GROWTH RISK-FACTORS PREGNANCY WOMEN OUTCOMES ASSOCIATION PREDICTION MANAGEMENT ULTRASOUND |
| Issue Date | 2-Jan-2020 |
| Publisher | JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE |
| Abstract | Objectives: Serial measurements of sonographic fetal abdominal circumference (AC) are useful for monitoring fetal growth during pregnancy and are essential for predicting macrosomia. The study was aiming to compare the AC profiles of infants born to mothers with or without hyperglycemia in Chinese population. Subjects and methods: The ?GDM Prevalence Study (GPS)? was a large study conducted in 22 hospitals in three large cities in China, which included 34,085 NGT (normal glucose tolerant) women, 8272 GDM (gestational diabetes mellitus) women and 729 DM (diabetes mellitus) women. A total of 116,740 scans and 103,377 valid AC measurements were performed for the NGT, GDM and DM groups at different gestational age. AC profiles and fetal growth rates at different stages of pregnancy were compared between different groups. Results: The overall AC growth rate (?) was higher in the macrosomia group than in the no macrosomia group in NGT (? =10.250 versus 9.541, p < .001), GDM (? = 10.572 versus 9.705, p < .001) and DM (? = 11.363 versus 9.924, p < .001) pregnancies. Significant differences were observed between NGT-macrosomia, GDM-macrosomia and DM-macrosomia. Significant differences were also noted between NGT-no macrosomia, GDM-no macrosomia and DM-no macrosomia women. Participants in NGT-macrosomia group exhibited larger AC values than NGT-no macrosomia group beginning at 21 gestational weeks, and GDM-macrosomia group exhibited larger AC values than GDM-no macrosomia group beginning at 22 gestational weeks. AC growth rate was higher in NGT-macrosomia and GDM-macrosomia groups than in the corresponding no macrosomia groups between 22 and 30 gestational weeks. Conclusions: The overall AC growth rates are higher in macrosomia group compared to the no macrosomia group in NGT, GDM as well as DM participants. The significant difference of AC growth rates in NGT-macrosomia and GDM-macrosomia indicate the possible differential underlying mechanisms in developing macrosomia with or without hyperglycemia exposure. Our study demonstrate that larger fetal AC measurements around 21?22 weeks are associated with subsequent diagnosis of macrosomia, suggesting that macrosomia management should be initiated much earlier than we thought. |
| URI | http://hdl.handle.net/20.500.11897/584721 |
| ISSN | 1476-7058 |
| DOI | 10.1080/14767058.2018.1487941 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 第三医院 首钢医院 |
