| Title | Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome |
| Authors | Schwartz, G. G. Steg, P. G. Szarek, M. Bhatt, D. L. Bittner, V. A. Diaz, R. Edelberg, J. M. Goodman, S. G. Hanotin, C. Harrington, R. A. Jukema, J. W. Lecorps, G. Mahaffey, K. W. Moryusef, A. Pordy, R. Quintero, K. Roe, M. T. Sasiela, W. J. Tamby, J.F. Tricoci, P. White, H. D. Zeiher, A. M. Aylward, Philip E. Drexel, Heinz Sinnaeve, Peter Dilic, Mirza Lopes, Renato D. Gotcheva, Nina N. Goodman, Shaun G. Prieto, Juan-Carlos Yong, Huo Lopez-Jaramillo, Patricio Pecin, Ivan Reiner, Zeljko Ostadal, Petr Poulsen, |
| Affiliation | Univ Colorado, Sch Med, Div Cardiol, Box B130, Aurora, CO 80045 USA. Paris Diderot Univ, Sorbonne Paris Cite, Hop Bichat, AP HP,FACT, Paris, France. INSERM, Unite 1148, Paris, France. Sanofi, Paris, France. Imperial Coll, Royal Brompton Hosp, Natl Heart & Lung Inst, London, England. SUNY Downstate, Sch Publ Hlth, Brooklyn, NY 11203 USA. Regeneron Pharmaceut, Tarrytown, NY USA. Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA. Harvard Med Sch, Boston, MA USA. Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL USA. Estudios Cardiol Latinoamer, Inst Cardiovasc Rosario, Rosario, Santa Fe, Argentina. Sanofi, Bridgewater, MA USA. Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada. Univ Toronto, St Michaels Hosp, Toronto, ON, Canada. Stanford Univ, Dept Med, Stanford Ctr Clin Res, Stanford, CA 94305 USA. Leiden Univ, Med Ctr, Dept Cardiol, Leiden, Netherlands. Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA. Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA. Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand. Goethe Univ, Dept Med 3, Frankfurt, Germany. Estudios Cardiol Latinoamer, Rosario, Santa Fe, Argentina. Flinders Univ & Med Ctr, South Australian Hlth & Med Res Inst, Adelaide, SA, Australia. Landeskrankenhaus Feldkirch, Feldkirch, Austria. UZ Leuven, Leuven, Belgium. Univ Clin Ctr Sarajevo, Sarajevo, Bosnia & Herceg. MHAT Natl Cardiol Hosp EAD, Sofia, Bulgaria. Hosp Clin Univ Chile, Santiago, Chile. Peking Univ First Hosp, Beijing, Peoples R China. Fdn Oftalmol Santander FOSCAL, Floridablanca, Colombia. Univ Zagreb, Univ Hosp Ctr Zagreb, Zagreb Sch Med, Zagreb, Croatia. Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Zagreb, Croatia. Na Homolce Hosp, Prague, Czech Republic. Aarhus Univ Hosp Skejby, Aarhus N, Denmark. SA Pohja Eesti Reg Haigla, Tallinn, Estonia. HUCH, Div Cardiol, Heart & Lung Ctr, Helsinki, Finland. FACT, Hop Europeen Georges Pompidou, Paris, France. Chapidze Emergency Cardiol Ctr, Tbilisi, Georgia. Univ Klinikum Aachen, Aachen, Germany. Univ Gen Hosp Ioannina, Ioannina, Greece. Clin Privada, Unidad Diagnost Cardiol, Guatemala City, Guatemala. Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China. Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary. St Johns Med Coll, Bangalore, Karnataka, India. Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel. Univ Ferrara, Unit Operat Cardiol, Ferrara, Italy. Kyoto Univ, Grad Sch Med, Kyoto, Kyoto, Japan. Seoul Natl Univ Hosp, Seoul, South Korea. SMG Seoul Natl Univ, Boramae Med Ctr, Seoul, South Korea. Pauls Stradins Clin Univ Hosp, Riga, Latvia. Vilnius Univ Hosp, Santaros Klin, Vilnius, Lithuania. Univ Clin Cardiol, Skopje, Macedonia. Univ Teknol MARA UiTM Selayang Campus, Batu Caves, Malaysia. UCSI Univ, Kuala Lumpur, Malaysia. Med Off, Guadalajara, Jalisco, Mexico. Amphia Ziekenhuis Molengracht, Breda, Netherlands. Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand. Oslo Univ Sykehus HF, Oslo, Norway. Hosp Nacl IV Alberto Sabogal Sologuren, Callao, Peru. Cardinal Santos Med Ctr, San Juan, Philippines. Grochowski Hosp, Postgrad Med Sch, Warsaw, Poland. Ctr Hosp Leiria Pombal, Leiria, Portugal. Clin Emergency Hosp Bucharest, Bucharest, Romania. Russian Cardiol Sci Prod Complex, Moscow, Russia. Clin Ctr Serbia, Belgrade, Serbia. Natl Heart Ctr, Singapore, Singapore. Univ Nemocn Bratislava, Interna Klin 1, Bratislava, Slovakia. Univ Med Ctr Ljubljana, Div Med, Dept Vasc Med, Prevent Cardiol Unit, Ljubljana, Slovenia. Univ Ljubljana, Fac Med, Ljubljana, Slovenia. Milpark Hosp, Johannesburg, South Africa. Fdn Jimenez Diaz, Madrid, Spain. Univ Kelaniya, Clin Trials Unit, Colombo, Sri Lanka. Uppsala Univ Hosp, Uppsala, Sweden. Univ Spital Basel, Basel, Switzerland. Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan. Natl Yang Ming Univ, Taipei, Taiwan. Ramathibodi Hosp, Bangkok, Thailand. Dokuz Eylul Univ, Tip Fak, Izmir, Turkey. MD Strazhesko Inst Cardiol AMS Ukraine, Kiev, Ukraine. Imperial Coll London, London, England. Univ Kansas, Med Ctr, Clin Pharmacol, Kansas City, KS 66103 USA. Duke Clin Res Inst, Durham, NC USA. Univ Colorado Denver, Denver, CO USA. St Louis Univ, St Louis Univ Ctr Hlth Outcomes Res, St Louis, MO USA. Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA 15260 USA. Linkoping Univ, Dept Med & Hlth, Linkoping, Sweden. Univ Montreal, Inst Cardiol, Montreal, PQ, Canada. Erasmus MC, Rotterdam, Netherlands. Duke Univ, Duke Clin Res Inst, Durham, NC USA. Mt Sinai Sch Med, New York, NY USA. Duke Univ, Durham, NC USA. Brazilian Clin Res Inst, Sao Paulo, Brazil. Hop Bichat Claude Bernard, AP HP, Paris, France. Stanford Univ, Stanford, CA 94305 USA. Univ N Carolina, Chapel Hill, NC USA. Fdn IRCCS Policlin S Matteo, Pavia, Italy. Hop Europeen Georges Pompidou, Paris, France. Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada. Clin Del Prado, Cordoba, Cordoba, Argentina. Clin Privada Prov, Merlo, Buenos Aires, Argentina. Ctr Invest Med Mar del Plata, Mar Del Plata, Buenos Aires, Argentina. Consultorios Asoc Endocrinol & Inv Clin Aplicad, Caba, Buenos Aires, Argentina. Clin FUSAVIM Privada, Villa Maria, Cordoba, Argentina. Inst Cardiovasc Buenos Aires, Buenos Aires, Buenos Aires, Argentina. Inst Med Aguero, Moron, Buenos Aires, Argentina. Fdn Favaloro Docencia & Invest Med, Caba, Buenos Aires, Argentina. Hosp Cent Mendoza, Mendoza, Mendoza, Argentina. Sanatorio Santa Rosa, Santa Rosa, La Pampa, Argentina. Ctr Invest Clin Litoral, Santa Fe, Santa Fe, Argentina. Dim Clin Privada, Ramos Mejia, Buenos Aires, Argentina. Clin Coronel Suarez, Coronel Suarez, Buenos Aires, Argentina. Sanatorio San Martin SA, Venado Tuerto, Santa Fe, Argentina. Inst Med DAMIC, Cordoba, Cordoba, Argentina. Hosp Italiano La Plata, La Plata, Buenos Aires, Argentina. Invest Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina. Inst Invest Clin, Mar Del Plata, Buenos Aires, Argentina. Inst Diagnost La Plata, La Plata, Buenos Aires, Argentina. Hosp Privado Ctr Med Cordoba, Cordoba, Cordoba, Argentina. Cordis Inst Corazon, Resistencia, Chaco, Argentina. Clin Chutro SRL, Cordoba, Cordoba, Argentina. Sanat Allende, Cordoba, Cordoba, Argentina. Inst Invest Clin Quilmes, Quilmes, Buenos Aires, Argentina. Inst Cardiol Corrientes, Corrientes, Corrientes, Argentina. Corp Med San Martin, San Martin, Buenos Aires, Argentina. Grp Med Alem, San Isidro, Buenos Aires, Argentina. Hosp Reg Espanol Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina. Ctr Invest & Prevenc Cardiovasc, Caba, Buenos Aires, Argentina. Fdn Estudios Clin, Inst Med, Rosario, Santa Fe, Argentina. Sanat Mariano Pelliza, Olivos, Buenos Aires, Argentina. Inst Invest Clin Zarate, Zarate, Buenos Aires, Argentina. IMEP, Ciudadela, Buenos Aires, Argentina. Sanat San Francisco, Santiago Del Estero, Santiago Estero, Argentina. Clin & Maternidad Suizo Argentina, Caba, Buenos Aires, Argentina. Hosp Italiano, Cordoba, Cordoba, Argentina. Ctr Med Lebensohn, Junin, Buenos Aires, Argentina. Clin Olivos, Olivos, Buenos Aires, Argentina. Medeos, Caba, Buenos Aires, Argentina. Clin Colombo, Cordoba, Cordoba, Argentina. Inst Privado Invest Clin Cordoba, Cordoba, Cordoba, Argentina. Ctr Modelo Cardiol, San Miguel De Tucuman, Tucuman, Argentina. Hosp Italiano Buenos Aires, Buenos Aires, Buenos Aires, Argentina. Hosp Prov Dr Jose Maria Cullen, Santa Fe, Santa Fe, Argentina. Inst Invest Clin San Nicolas, San Nicolas, Buenos Aires, Argentina. Sanatorio Guemes, Caba, Buenos Aires, Argentina. Ctr Med Luquez, Cordoba, Cordoba, Argentina. Clin Inst Med Adrogue, Almirante Brown, Buenos Aires, Argentina. Sanat Parque SA, Salta, Salta, Argentina. Coffs Harbour Hlth Campus, Coffs Harbour, NSW, Australia. John Hunter Hosp, New Lambton Hts, NSW, Australia. Mildura Cardiol, Mildura, Vic, Australia. Calvary Clin, Bruce, ACT, Australia. Alfred Hosp, Prahran, Vic, Australia. Northern Cardiol & Specialist Clin, Elizabeth Vale, SA, Australia. Queen Elizabeth Hosp, Woodville, SA, Australia. Gosford Hosp, Gosford, NSW, Australia. Wesley Med Ctr, Auchenflower, Qld, Australia. Ballarat Hlth Serv, Ballarat, Vic, Australia. Royal Hobart Hosp, Hobart, Tas, Australia. Prince Charles Hosp, Chermside, Qld, Australia. Adelaide Med Res, Ashford, SA, Australia. Nambour Gen Hosp, Nambour, Qld, Australia. Princess Alexandra Hosp, Woolloongabba, Qld, Australia. Cairns Hosp, Cairns, Qld, Australia. St George Hosp, Kogarah, NSW, Australia. Redcliffe Hosp, Redcliffe, Qld, Australia. Univ Klinikum Graz, Graz, Austria. Univ Klinikum Salzburg, Salzburg, Austria. Vorarlberg Inst Vaskulare Forsch VIVIT, Feldkirch, Austria. Wilhelminenspital Stadt Wien, Vienna, Austria. KH Barmherzigen Bruder Eisenstadt, Kardiol & Nephrol, Eisenstadt, Austria. Krankenanstalt Rudolfstiftung Stadt Wien, Vienna, Austria. Mariaziekenhuis Vzw, Overpelt, Belgium. AZ St Lucas, Ghent, Belgium. Clin St Pierre, Ottignies, Belgium. CHU Tivoli, La Louviere, Belgium. CHR Citadelle, Liege, Belgium. ZOL, Genk, Belgium. Private Practice, Tienen, Belgium. ZNA Stuivenberg, Antwerp, Belgium. Clin St Jean, Brussels, Belgium. AZ Delta, Roeselare, Belgium. UCL St Luc, Brussels, Belgium. AZ St Maarten, Mechelen, Belgium. Heilig Hart Ziekenhuis, Mol, Belgium. ZNA Middelheim, Antwerp, Belgium. Imelda Hosp, Bonheiden, Belgium. OL Vrouwziekenhuis Campus Aalst, Aalst, Belgium. UZ Antwerpen, Edegem, Belgium. AZ Klina, Brasschaat, Belgium. Heart Ctr BH, Tuzla, Bosnia & Herceg. Univ Med Ctr Tuzla, Tuzla, Bosnia & Herceg. Cantonal Hosp Dr Irfan Ljubijank Bihac, Bihac, Bosnia & Herceg. Cantonal Hosp Zenica, Zenica, Bosnia & Herceg. Univ Clin Hosp Mostar, Mostar, Bosnia & Herceg. Clin Ctr Banja Luka, Banja Luka, Bosnia & Herceg. Reg Med Ctr Dr Safet Mujic, Mostar, Bosnia & Herceg. CARDRESEARCH Cardiol Assistencial & Pesquisa, Belo Horizonte, MG, Brazil. Hosp Coracao Brasil, Brasilia, DF, Brazil. INCOR Inst Coracao, Sao Paulo, Brazil. Hosp Sao Francisco De Assis, Belo Horizonte, MG, Brazil. Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil. Hosp Base Sao Jose Rio Preto, Sao Paulo, Brazil. Hosp Univ Ulbra, Canoas, Brazil. Hosp Evangelico Curitiba, Curitiba, Parana, Brazil. Inst Ensino Pesquisa Clin Ceara Ltda, Fortaleza, Ceara, Brazil. Hosp Sao Vicente De Paulo, Passo Fundo, RS, Brazil. Inst Cardiol Do Rio Grande Do Sul, Porto Alegre, RS, Brazil. Hosp Santa Isabel, Soc Div Providencia, Blumenau, Santa Catarina, Brazil. Santa Casa Misericordia Pelotas, Pelotas, RS, Brazil. Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil. Soc Beneficiente Senhoras Hosp Sirio Libanes, Sao Paulo, Brazil. Ctr Cardiol & Radiol Intervencionista LTDA, Aparecida Goiania, Brazil. Hosp Vera Cruz NUPEC, Belo Horizonte, MG, Brazil. Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil. Inst Ensino Consultoria & Pesquisa Clin LTDA ME, Belo Horizonte, MG, Brazil. CPCLIN, Sao Paulo, Brazil. Clin LOEMA, Campinas, Brazil. Santa Casa Porto Alegre, Porto Alegre, RS, Brazil. Inst Coracao Triangulo, Uberlandia, MG, Brazil. CCBR Brasil, Rio De Janeiro, Brazil. IMV Inst Med Vasc Hosp Mae de Deus, Porto Alegre, RS, Brazil. Soc Hosp Angelina Caron, Campina Grande Do Sul, Parana, Brazil. Santa Casa Curitiba, Curitiba, Parana, Brazil. Esho Empresa Serv Hosp SA, Sao Paulo, SP, Brazil. Fac Med ABC CEMEC, Sao Bernardo Do Campo, SP, Brazil. Inst Molestias Cardiovasc Tatui IMC, Tatui, SP, Brazil. HCFMRP, Riberao, Preto, Brazil. Hosp Santa Izabel Santa Casa Misericordia Bahia, Salvador, BA, Brazil. Ctr Cardiol Clin & Pesquisa Dra Juliana Souz, Brasilia, DF, Brazil. FGM Clin Paulista Doencas Cardiovasc, Sao Paulo, Brazil. Barroso & Sebba Ltda, Goiania, Go, Brazil. Hosp Clin Gaspar Vianna, Belem, Para, Brazil. Univ Fed Sao Paulo UNIFESP EPM, Sao Paulo, Brazil. Hosp Estadual Mario Covas, Santo Andre, Brazil. Inst Molestias Cardiovasc IMC Sao Jose do Rio Pre, Sao Jose Do Rio Preto, Brazil. 2 MHAT, Sofia, Bulgaria. Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria. Specialized Hosp Act Treatment Cardiol, Pleven, Bulgaria. UMHAT Dr Georgi Stranski, Pleven, Bulgaria. Multiprof Distr Hosp Act Treatment Dr St Cherkezo, Veliko Tarnovo, Bulgaria. Multiprofile Hosp Act Treatment Burgas AD, Burgas, Bulgaria. Specialized Hosp Act Cardio Treatment Cardiolife, Varna, Bulgaria. MHAT Bratan Shukerov AD, Cardio Dept Inrtens Unite, Smoljan, Bulgaria. UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria. MHAT Sveti Vrach EOOD, Sandanski, Bulgaria. First Multiprofile Hosp Act Treatment Sofia EAD, Sofia, Bulgaria. MHAT Lyulin EAD Dept Internal Dis, Sofia, Bulgaria. MHAT Blagoevgrad AD, Blagoevgrad, Bulgaria. MHAT Natl Cardiol Hosp EAD, Sofia, Bulgaria. UMHAT Alexandrovska EAD, Sofia, Bulgaria. NMT Hosp Tsar Boris III, Sofia, Bulgaria. Multiprofile Hosp Act Treatment Pazardzhik AD, Pazardzhik, Bulgaria. Fifth MHAT Sofia EAD, Sofia, Bulgaria. Dr MPJ Senaratne Professional Corp, Edmonton, AB, Canada. TotalCardiology, Calgary, AB, Canada. Surrey Mem Hosp, Surrey, BC, Canada. Ctr Hosp Beauce Etchemin, St Georges De Beauce, PQ, Canada. CardioVasc HR, St Jean, PQ, Canada. St Jerome Med Res Inc, St Jerome, PQ, Canada. Cambridge Cardiac Care Ctr, Cambridge, ON, Canada. Victoria Heart Inst Fdn, Victoria, BC, Canada. Ctr Hosp Pierre Le Gardeur, Terrebonne, PQ, Canada. Vizel Cardiac Res, Cambridge, ON, Canada. Discovery Clin Serv, Victoria, BC, Canada. GA Res Associates Ltd, Moncton, NB, Canada. Ctr Sante & Serv Sociaux Haute Yamaska, Granby, PQ, Canada. Ctr Depistage & Rech Cardiovasc Rive Sud, Longueuil, PQ, Canada. Gen Hosp Hlth Sci Ctr, St John, NF, Canada. Ctr Hosp Reg Lanaudiere, Joliette, PQ, Canada. Cape Breton Reg Hosp, Sydney, NS, Canada. Ctr Hosp Reg Trois Rivieres, Trois Rivieres, PQ, Canada. Clin Cardiol Levis, Levis, PQ, Canada. Newmarket Cardiol Res Grp, Newmarket, ON, Canada. Royal Alexandra Hosp, Edmonton, AB, Canada. Royal Columbian Hosp, New Westminster, BC, Canada. Thunder Bay Reg Hlth Sci Ctr, Thunder Bay, ON, Canada. Ottawa Heart Inst, Ottawa, ON, Canada. Red Deer Reg Hosp Ctr, Red Deer, AB, Canada. Scarborough Cardiol Res, Scarborough, ON, Canada. St Boniface Gen Hosp, Winnipeg, MB, Canada. Hotel Dieu Ctr Hosp Univ Sherbrooke, Sherbrooke, PQ, Canada. Hamilton Gen Hosp, Hamilton, ON, Canada. Lakeridge Hlth Oshawa, Oshawa, ON, Canada. Ctr Sante & Serv Sociaux Reg Thetford Rech, Thetford Mines, PQ, Canada. St Johns Hosp, St John, NB, Canada. Laval Hosp, Quebec Heart Inst, Quebec City, PQ, Canada. Rech GCP Res, Montreal, PQ, Canada. Penticton Reg Hosp, Penticton, BC, Canada. Montreal Gen Hosp, Montreal, PQ, Canada. Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada. Med Profess Corp, St Catharines, ON, Canada. Ctr Invest Clin Cics, Temuco, Chile. Corp Beneficencia Osorno, Osorno, Chile. Hosp Clin Univ Chile, Santiago, Chile. Univ Catolica, Ctr Invest Clin, Santiago, Chile. Hosp Barros Luco, Santiago, Chile. Hosp Salvador, Santiago, Chile. Hosp Naval Almirante Nef Vina del Mar, Vina Del Mar, Chile. Hosp Clin Magallanes, Punta Arenas, Chile. Clin Alemana Santiago, Santiago, Chile. Hosp Clin Reg Dr Guillermo Grant Benavente, Concepcion, Chile. Psicomed Clin & Res Grp, Santiago, Chile. Biomed Res Grp, Santiago, Chile. Clin Univ Catolica Maule, Talca, Chile. Estudios Clin V Reg Ltda, Vina Del Mar, Chile. Hosp & CRS El Pino, Santiago, Chile. Guangdong Gen Hosp, Guangzhou, Guangdong, Peoples R China. Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Guangdong, Peoples R China. Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China. Siping Cent Peoples Hosp, Siping, Peoples R China. Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Peoples R China. Tianjin Union Med Ctr, Tianjin, Peoples R China. Yanbian Univ Hosp, Yanji, Peoples R China. TEDA Int Cardiovasc Hosp, Tianjin, Peoples R China. Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China. Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Guangdong, Peoples R China. Peking Univ, Hosp 1, Beijing, Peoples R China. Jilin Prov Peoples Hosp, Changchun, Jilin, Peoples R China. Xuzhou Med Coll, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China. Guizhou Prov Peoples Hosp, Guiyang, Guizhou, Peoples R China. Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China. Shenzhen Peoples Hosp, Shenzhen, Peoples R China. Shandong Univ, Jinan Cent Hosp Affiliated, Jinan, Shandong, Peoples R China. Affiliated Hosp NJMU, Nanjing Drum Tower Hosp, Nanjing, Jiangsu, Peoples R China. Wuhan Asian Heart Hosp, Wuhan, Hubei, Peoples R China. Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China. Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Fujian, Peoples R China. Third Peoples Hosp Hubei Prov, Wuhan, Hubei, Peoples R China. Tianjin 4th Ctr Hosp, Tianjin, Peoples R China. Southeast Univ, Zhongda Hosp, Nanjing, Jiangsu, Peoples R China. Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China. Beijing Chaoyang Hosp, Beijing, Peoples R China. China Japan Friendship Hosp, Beijing, Peoples R China. Baotou Med Coll, Affiliated Hosp 1, Baotou, Peoples R China. Lanzhou Univ, Hosp 1, Lanzhou, Gansu, Peoples R China. Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China. Nanjing Mil Command, Fuzhou Gen Hosp, Nanjing, Jiangsu, Peoples R China. Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China. China Aerosp Corp, Cent Hosp, Beijing, Peoples R China. Jilin Univ, Hosp 1, Changchun, Jilin, Peoples R China. China Med Univ, Shengjing Hosp, Shenyang, Liaoning, Peoples R China. Cent S Univ, Xiangya Hosp 2, Changsha, Hunan, Peoples R China. Shanghai East Hosp, Shanghai, Peoples R China. Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China. Shanghai First Peoples Hosp, Shanghai, Peoples R China. Zhejiang Hosp, Hangzhou, Zhejiang, Peoples R China. Zhejiang Prov Peoples Hosp, Hangzhou, Zhejiang, Peoples R China. Cent S Univ, Xiangya Hosp 3, Changsha, Hunan, Peoples R China. Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China. Inner Mongolia Peoples Hosp, Hohhot, Peoples R China. Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Shaanxi, Peoples R China. Hunan Prov Peoples Hosp, Changsha, Hunan, Peoples R China. First Peoples Hosp Yueyang, Yueyang, Peoples R China. Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China. Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China. Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Zhejiang, Peoples R China. Lanzhou Univ, Hosp 2, Lanzhou, Gansu, Peoples R China. Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai, Peoples R China. Shaanxi Prov Peoples Hosp, Xian, Shaanxi, Peoples R China. Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China. Zhejiang Univ, Affiliated Hosp 2, Hangzhou, Zhejiang, Peoples R China. Ctr Med Ejercicio & Rehabilitac Cardiaca, Medellin, Colombia. Fdn Cardiomet Eje Cafetero CEQUIN, Armenia, Quindio, Colombia. Hosp Santa Clara, Bogota, Colombia. IPS Rodrigo Botero SAS, Medellin, Colombia. Asociac IPS Med Internistas Caldas, Manizales, Colombia. Clin Costa ltda, Barranquilla, Colombia. Fdn Oftalmolog FOSCAL, Bucaramanga, Colombia. Caja Compensac Familiar CAFAM, Bogota, Colombia. Fdn Ctr Invest Biomed Riescard, Espinal Tolima, Colombia. IPS Ctr Med Julian Coronel SA, Cali, Valle, Colombia. IPS Ctr Cient Asistencial Jose Luis Accini SAS, Barranquilla, Colombia. Ctr Cardiovasc Colombiano Clin Santa Maria, Medellin, Colombia. Ctr Med Imbanaco Cali SA, Cali, Valle, Colombia. Ctr Diagnost Cardiol LTDA, Cartagena, Colombia. Ctr Cardiovasc Aristides Sotomayor Santa Lucia SA, Cartagena, Bolivar, Colombia. SIMEDICS IPS SAS, Bogota, Colombia. Fdn Caribe Invest Biomed, Barranquilla, Colombia. FN Brno, Brno, Czech Republic. Krajska Nemocnice Liberec, Liberec, Czech Republic. Fak Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic. Fak Nemocnice Motole, Prague, Czech Republic. InterkardioML SRO, Interni Kardiol Ambulance, Marianske Lazne, Czech Republic. Vseobecna Fak Nemocnice Praze, Prague, Czech Republic. Nemocnice Pardubickeho Kraje AS, Pardubice, Czech Republic. Mestska Nemocnice Ostrava, Ostrava, Czech Republic. Fak Nemocnice Plzen, Plzen, Czech Republic. Ctr Choroby Srdce Cev, Kromeriz, Czech Republic. Krajska Nemocnice Tomase Bati AS, Zlin, Czech Republic. Inst Klin Expt Med, Prague, Czech Republic. Oblastni Nemocnice Kladno AS, Kladno, Czech Republic. Thomayerova Nemocnice, Prague, Czech Republic. Fak Nemocnice Kralovske Vinohrady, Prague, Czech Republic. KARDIO SEVER SRO, Ceska Lipa, Czech Republic. Kardiol Ambulance, Rakovnik, Czech Republic. Nemocnice Na Homolce, Prague, Czech Republic. Fak Nemocnice Olomouc, Olomouc, Czech Republic. Kardiol SRO, Cesky Krumlov, Czech Republic. Cardioctr Kladno SRO, PP Klin Kladno, Kladno, Czech Republic. Dep Cardiol, Aalborg, Denmark. Rigshosp Hjertecentret, Copenhagen, Denmark. Region Hosp Herning, Herning, Denmark. Hvidovre Univ Hosp, Hvidovre, Denmark. Reg Hosp Silkeborg, Silkeborg, Denmark. Gentofte Univ Hosp, Hellerup, Denmark. Naestved Sygehus, Naestved, Denmark. Sygehus Lillebaelt, Vejle Sygehus, Vejle, Denmark. Glostrup Cty Hosp, Glostrup, Denmark. Sjaellands Univ Hosp Koge, Koge, Denmark. Holbaek Sygehus, Holbaek, Denmark. Slagelse Sygehus, Slagelse, Denmark. Reg Hosp Viborg, Viborg, Denmark. Hillerod Hosp, Hillerod, Denmark. Sygehus Sonderjylland, Aabenraa, Denmark. Odense Univ Hosp, Odense C, Denmark. SA Viljandi Haigla, Viljandimaa, Estonia. SA Parnu Haigla, Parnu, Estonia. AS Ida Tallinna Keskhaigla, Tallinn, Estonia. SA Tartu Ulikooli Kliinikum, Tartu, Estonia. Mustamae Tervisekeskus OU, Tallinn, Estonia. Helsinki Univ Hosp, Biomed, Helsinki, Finland. Helsinki Univ Hosp, Div Cardiol, Helsinki, Finland. Turku Univ Hosp, Ctr Heart, Turku, Finland. Tampere Univ Hosp, Ctr Heart, Tampere, Finland. Tampere Univ Hosp, Internal Med, Tampere, Finland. Univ Hosp Oulu, Oulu, Finland. Univ Oulu, Oulu, Finland. Hop Cardiol Haut Leveque, Pessac, France. Hop Louis Pasteur, Nice, France. Nouvel Hop Civil, Strasbourg, France. Hop La Pitie Salpetriere, Paris, France. CHU Albert Michallon, Grenoble, France. CHU Brest, Hop Cavale Blanche, Brest, France. CHU Dijon Bocage Cent, Dijon, France. Hop Bichat Claude Bernard, Paris, France. Hop Arnaud Villeneuve, Montpellier, France. Ctr Hosp Cambrai, Cambrai, France. Ctr Hosp Gen, Pau, France. Hop St Antoine, Paris, France. Hop Nord Marseille, Marseille, France. CH Compiegne Noyon, Compiegne, France. CHU Jean Minjoz, Besancon, France. CHU Dupuytren, Limoges, France. CHU Nantes, Nantes, France. Clin St Hilaire, Rouen, France. Inst Hosp Jacques Cartier, Massy, France. Aleksandr Aladashvili Clin LLC, Tbilisi, Georgia. Tbilisi Heart & Vasc Clin Ltd, Tbilisi, Georgia. Ctr Vasc & Heart Dis, Tbilisi, Georgia. Unimed Ajara Batumi Refferal Hosp, Batumi, Georgia. LTD Clin LJ, Kutaisi, Georgia. St Johannes Hosp, Dortmund, Germany. Charite Univ Med Campus Benjamin Franklin, Berlin, Germany. Studienzentrum Dr Appel, Kassel, Germany. Cardiologicum Hamburg, Hamburg, Germany. GFO Kliniken Bonn, Bonn, Germany. Klinikum Bielefeld Mitte, Bielefeld, Germany. Joseph Hosp Warendorf, Warendorf, Germany. DRK Kliniken Berlin Kopenick, Berlin, Germany. MediClin Fachklin Rhein Ruhr, Essen, Germany. Univ Herzzentrum Freiburg, Freiburg, Germany. Inst Klin Forschung, Rotenburg, Germany. Klinikum Dortmund, Dortmund, Germany. Univ Klinikum Saarlandes, Homburg, Germany. Univ Klinikum Aachen, Aachen, Germany. Univ Klinikum Halle Saale, Halle, Saale, Germany. ClinPhenomics GmbH & Co KG, Frankfurt, Germany. Vivantes Humboldt Klinikum, Berlin, Germany. Univ Herzzentrum Hamburg GmbH, Hamburg, Germany. FAZ Dresden Neustadt GbR, Dresden, Germany. Univ Klinikum Mainz, Mainz, Germany. Univ Klinikum Bonn, Bonn, Germany. Univ Herzzentrum Freiburg Bad Krozingen, Bad Krozingen, Germany. St Marien Hosp Hamm, Hamm, Germany. Univ Klinikum Magdeburg, Magdeburg, Germany. Robert Bosch Krankenhaus GmbH, Stuttgart, Germany. Sana Kliniken Lubeck, Lubeck, Germany. Klin See, Rudersdorf, Germany. Univ Klinikum Munster, Munster, Germany. HPK Heidelberger Privatklin Kardiol, Heidelberg, Germany. Krankenhausgesell St Vincenz mbH, Limburg, Germany. DreifaltigkeitsHosp Lippstadt, Lippstadt, Germany. MVZ Ambulantes Kardiol Zentrum Peine GbR, Peine, Germany. Konstantopouleio Gen Hosp Nea Ionia, Athens, Greece. Skylitseio Gen Hosp Chios, Chios, Greece. Asklipeio Gen Hosp, Athens, Greece. Sismanogleio Gen Hosp Attica, Maroussi, Greece. Univ Gen Hosp Ioannina, Ioannina, Greece. Ippokrateio Gen Hosp, Athens, Greece. 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Hosp Lithuanian Univ Hlth Sci, Kaunas, Lithuania. Klaipeda Seamens Hosp, Klaipeda, Lithuania. Private Med Ctr Kardivita, Vilnius, Lithuania. Private Cardiol Clin Sirdies Namai, Vilnius, Lithuania. Elite Med, Kaunas, Lithuania. Cardiol Diagnost Ctr, Tetovo, Macedonia. Clin Hosp Dr Trifun Panovski, Bitola, Macedonia. Mil Med Ctr, Skopje, Macedonia. PHI Clin Hosp Shtip, Shtip, Macedonia. Sarawak Gen Hosp, Kuching, Malaysia. Univ Teknol MARA UiTM, Sungai Buloh Campus, Sungai Buloh, Selangor, Malaysia. Hosp Univ Kebangsaan Malaysia, Kuala Lumpur, |
| Keywords | MYOCARDIAL-INFARCTION MONOCLONAL-ANTIBODY REDUCING LIPIDS TASK-FORCE PCSK9 MANAGEMENT EFFICACY SAFETY LDL ASSOCIATION |
| Issue Date | 2018 |
| Publisher | NEW ENGLAND JOURNAL OF MEDICINE |
| Citation | NEW ENGLAND JOURNAL OF MEDICINE. 2018, 379(22), 2097-2107. |
| Abstract | BACKGROUND Patients who have had an acute coronary syndrome are at high risk for recurrent ischemic cardiovascular events. We sought to determine whether alirocumab, a human monoclonal antibody to proprotein convertase subtilisin-kexin type 9 (PCSK9), would improve cardiovascular outcomes after an acute coronary syndrome in patients receiving high-intensity statin therapy. METHODS We conducted a multicenter, randomized, double-blind, placebo-controlled trial involving 18,924 patients who had an acute coronary syndrome 1 to 12 months earlier, had a low-density lipoprotein (LDL) cholesterol level of at least 70 mg per deciliter (1.8 mmol per liter), a non-high-density lipoprotein cholesterol level of at least 100 mg per deciliter (2.6 mmol per liter), or an apolipoprotein B level of at least 80 mg per deciliter, and were receiving statin therapy at a high-intensity dose or at the maximum tolerated dose. Patients were randomly assigned to receive alirocumab subcutaneously at a dose of 75 mg (9462 patients) or matching placebo (9462 patients) every 2 weeks. The dose of alirocumab was adjusted under blinded conditions to target an LDL cholesterol level of 25 to 50 mg per deciliter (0.6 to 1.3 mmol per liter). The primary end point was a composite of death from coronary heart disease, nonfatal myocardial infarction, fatal or nonfatal ischemic stroke, or unstable angina requiring hospitalization. RESULTS The median duration of follow-up was 2.8 years. A composite primary end-point event occurred in 903 patients (9.5%) in the alirocumab group and in 1052 patients (11.1%) in the placebo group (hazard ratio, 0.85; 95% confidence interval [CI], 0.78 to 0.93; P<0.001). A total of 334 patients (3.5%) in the alirocumab group and 392 patients (4.1%) in the placebo group died (hazard ratio, 0.85; 95% CI, 0.73 to 0.98). The absolute benefit of alirocumab with respect to the composite primary end point was greater among patients who had a baseline LDL cholesterol level of 100 mg or more per deciliter than among patients who had a lower baseline level. The incidence of adverse events was similar in the two groups, with the exception of local injection-site reactions (3.8% in the alirocumab group vs. 2.1% in the placebo group). CONCLUSIONS Among patients who had a previous acute coronary syndrome and who were receiving high-intensity statin therapy, the risk of recurrent ischemic cardiovascular events was lower among those who received alirocumab than among those who received placebo. |
| URI | http://hdl.handle.net/20.500.11897/575631 |
| ISSN | 0028-4793 |
| DOI | 10.1056/NEJMoa1801174 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
