| Title | Risk factors of infection after endoscopic submucosal dissection of esophageal mucosal lesions |
| Authors | Zeng, Ranran Chen, Qianqian Linghu, Enqiang Dou, Yan Yang, Jing Lu, Zhongsheng |
| Affiliation | Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol, 28 Fuxing Rd, Beijing 100853, Peoples R China. Peking Univ, Int Hosp, Dept Gastroenterol, Beijing, Peoples R China. |
| Keywords | Endoscopic submucosal dissection esophagus postoperative bacteremia antibiotic PROPHYLACTIC ANTIBIOTICS CLINICAL-OUTCOMES LOW-FREQUENCY BACTEREMIA STRICTURE COMPLICATIONS PERFORATION |
| Issue Date | 2018 |
| Publisher | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE |
| Citation | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE. 2018, 11(12), 13736-13742. |
| Abstract | Aims: This study aims to analyze risk factors of infection after the endoscopic submucosal dissection (ESD) of esophageal mucosal lesions within 24 hours from the procedures, and formulate an antibiotic treatment plan. Methods: A total of 153 patients with esophageal mucosal lesions undergoing ESD in our hospital were enrolled from January 2010 to August 2016. Patients with fever (body temperature Z38.0 degrees C), elevated white blood cell (WBC) count (>10x10(9)), and/or elevated C-reactive protein level (CRP) (>0.8 mg/L) within 24 hours from the procedures were regarded as the case group. The patients, lesions and procedure characteristics were retrospectively analyzed for risk factors of post-ESD infection. Results: The rate of post-ESD infection was 16.3% (25/153). The univariate analysis suggests that there are significant differences in the maximum diameters of the resected specimens (P = 0.005), the proportion of circumferential extension (P<0.001), operating time (P = 0.001), and exposure of the muscular layer (P< 0.001). The multivariate analysis reveal that the proportion of circumferential extension >3/4 (P = 0.028, OR: 5.391, 95% CI: 1.200-24.214) and exposure of the muscular layer (P = 0.005, OR: 7.776, 95% CI: 1.834-32.973) are independent risk factors for post-ESD infection. Conclusion: Exposure of the muscular layer and the proportion of circumferential extension >3/4 are reliable risk factors for post-ESD infection. Antibiotic therapy is recommended for its treatment. |
| URI | http://hdl.handle.net/20.500.11897/572367 |
| ISSN | 1940-5901 |
| Indexed | SCI(E) |
| Appears in Collections: | 国际医院 |
