| Title | An investigation of lower urinary tract symptoms and its potential associated factors in adult Chinese women with zero-inflated negative binomial regression model |
| Authors | Xu, Tao Zhang, Lei Li, Zhiyi Zhu, Lan Han, Shaomei |
| Affiliation | Chinese Acad Med Sci, Inst Basic Med Sci, Dept Epidemiol & Stat, Beijing, Peoples R China Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China Peking Union Med Coll Hosp, Peking Union Med Coll, Dept Gynecol & Obstet, Beijing, Peoples R China Peking Univ, Hosp 1, Dept Gynecol & Obstet, Beijing, Peoples R China |
| Keywords | bother China lower urinary tract symptoms potential associated factors zero-inflated negative binomial model |
| Issue Date | 2019 |
| Publisher | MEDICINE |
| Abstract | Lower urinary tract symptoms (LUTS) have detrimental impact on health-related quality of life. This study has 2 aims: first to identify the optimum model for LUTS study and then to explore the potential associated factors of LUTS and bother LUTS with the optimum model among adult women in China. The survey was conducted in 6 regions of China between February and July 2006. A modified Chinese Bristol Female LUTS questionnaire was administered. The number of LUTS was the main outcome measure. The fitting goodness was compared to identify the optimum model with likelihood ratio test statistics. Zero-inflated negative binomial (ZINB) model was used to explore the potential associated factors of LUTS and bother LUTS. Of all 18,992 respondents, 55.5% of respondents reported one (any LUTS) or more LUTS (mixed LUTS) and 36.5% of respondents reported one or more bother LUTS. With the largest log likelihood and smallest AIC and BIC, ZINB model showed the best goodness of fit. In the ZINB model, we identified multiple associated factors for any LUTS and mixed LUTS; older age (beta=0.2), overweight [beta=0.059, 95%CI (0.016 similar to 0.102)], obese [beta=0.143, 95%CI (0.087 similar to 0.198)], postmenopausal status [beta=0.099, 95%CI (0.023 similar to 0.175)], prolonged labor [beta=0.188, 95%CI (0.104 similar to 0.272)], constipation [beta=0.309, 95%CI (0.262 similar to 0.357)], coexisting pelvic organ prolapse (POP) [beta=0.348, 95%CI (0.224 similar to 0.473)], diabetes (beta=0.178, 95%CI (0.100 similar to 0.257), hypertension [beta=0.092, 95%CI (0.041 similar to 0.143)], smoking (beta=0.192, 95%CI (0.127 similar to 0.258) and alcohol consumption [beta=0.063, 95%CI (0.001 similar to 0.126)] increased the odds of mixed LUTS. We identified multiple associated factors for bother LUTS and mixed LUTS; older age (beta=0.1), prolonged labor [beta 0.153, 95%CI (0.031 similar to 0.275)], constipation [beta=0.359, 95%CI (0.292 similar to 0.426)] coexisting POP (beta=0.212, [95% CI (0.031 similar to 0.393)], diabetes [beta=.154, 95%CI (0.030 similar to 0.278)], and smoking [beta=0.169, 95%CI (0.076 similar to 0.262)] increased the odds of bother mixed LUTS. ZINB model was the optimum model to explore the potential associated factors of LUTS. Older age, coexisting POP and constipation were both closely related to any and bother LUTS, also the severity of LUTS. Compared to nulliparity, single or multiple deliveries and women who had perineal laceration had nothing to do with the severity of LUTS. |
| URI | http://hdl.handle.net/20.500.11897/553518 |
| ISSN | 0025-7974 |
| DOI | 10.1097/MD.0000000000017409 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
