| Title | F-18-FDGPET/CT in fever of unknown origin and inflammation of unknown origin: a Chinese multi-center study |
| Authors | Wang, Qian Li, Ya-Ming Li, Yuan Hua, Feng-Chun Wang, Quan-Shi Zhang, Xiao-Li Cheng, Chao Wu, Hua Yao, Zhi-Ming Zhang, Wei-Fang Hou, Qing-Yi Miao, Wei-Bing Wang, Xue-Mei |
| Affiliation | Peking Univ, Peoples Hosp, Dept Nucl Med, 11 Xizhimen South St, Beijing 100044, Peoples R China China Med Univ, Hosp 1, Dept Nucl Med, 155 Nanjing North St, Shenyang 110001, Liaoning, Peoples R China Fudan Univ, Huashan Hosp, PET Ctr, Shanghai, Peoples R China Southern Med Univ, Nanfang Hosp, PET Ctr, Guangzhou, Peoples R China Capital Med Univ, Beijing Anzhen Hosp, Dept Nucl Med, Beijing, Peoples R China Second Mil Med Univ, Changhai Hosp, Dept Nucl Med, Shanghai, Peoples R China Xiamen Univ, Affiliated Hosp 1, Xiamen Canc Hosp, Dept Nucl Med, Xiamen, Peoples R China Xiamen Univ, Affiliated Hosp 1, Xiamen Canc Hosp, Minnan PET Ctr, Xiamen, Peoples R China Beijing Hosp, Dept Nucl Med, Natl Ctr Gerontol, Beijing, Peoples R China Peking Univ, Dept Nucl Med, Hosp 3, Beijing, Peoples R China Guangdong Gen Hosp, PET Imaging Diagnost Ctr, Guangzhou, Guangdong, Peoples R China Guangdong Acad Med Sci, Guangzhou, Guangdong, Peoples R China Fujian Med Univ, Affiliated Hosp 1, Dept Nucl Med, Fuzhou, Fujian, Peoples R China Inner Mongolia Med Univ, Affiliated Hosp, Dept Nucl Med, Hohhot, Peoples R China |
| Keywords | Fever of unknown origin (FUO) Inflammation of unknown origin (IUO) Positron emission tomography Fluorodeoxyglucose |
| Issue Date | 2019 |
| Publisher | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING |
| Abstract | Purpose To evaluate the clinical value of F-18-FDG-PET/CT for the diagnosis of fever of unknown origin (FUO) and inflammation of unknown origin (IUO) in Chinese population, as well as the characteristics of PET/CT in different category of etiological disease. Methods A total of 376 consecutive patients with FUO/IUO who underwent FDG-PET/CT at 12 hospitals were retrospectively studied. FDG uptake was quantitatively and visually evaluated, by using SUVmax and a 4-grade scale respectively. A questionnaire survey to the clinicians was used to evaluate the significance of PET/CT in diagnosing of FUO/IUO. Data analysis included the etiological distribution in the study population, image characteristics in different category of diseases, and clinical significance of PET/CT. Results In 376 studied patients, the infectious diseases accounted for 33.0% of patients, rheumatologic diseases for 32.4%, malignancies for 19.1%, miscellaneous causes for 6.6%, and cause unknown for 8.8%. However, the etiological distribution among hospitals was varied. In addition, the etiological disease composition ratio has changed over time in China. On PET/CT examinations, 358 (95.2%) of the patients had a positive finding. Within them, local high uptake lesion was found in 219 cases, and nonspecific abnormal uptake (NAU) was found in 187 cases. FDG uptake in malignant diseases was significantly higher than in other category diseases both on SUVmax and visual scores (t-value range from 4.098 to 5.612, all P value < 0.001). Based on a clinical questionnaire survey, PET/CT provided additional diagnostic information for 77.4% of patients, and 89.6% of patients benefited from PET/CT examination. Conclusions FDG PET/CT is a valuable tool for clinical diagnosis of FUO/IUO, and it is of great significance in further investigating the usefulness of PET/CT in non-neoplastic diseases. |
| URI | http://hdl.handle.net/20.500.11897/552466 |
| ISSN | 1619-7070 |
| DOI | 10.1007/s00259-018-4121-1 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 第三医院 |
