| Title | A nanoencapsulation suspension biomimetic of milk structure for enhanced maternal and fetal absorptions of DHA to improve early brain development |
| Authors | Zeng, Jie Yu, Wenxuan Dong, Xiaoli Zhao, Shanting Wang, Zhe Liu, Yajie Wong, Man-Sau Wang, Yi |
| Affiliation | Hong Kong Polytech Univ, Shenzhen Res Inst, State Key Lab Chinese Med & Mol Pharmacol Incubat, Shenzhen 518057, Peoples R China Hong Kong Polytech Univ, Shenzhen Res Inst, Shenzhen Key Lab Food Biol Safety Control, Shenzhen 518057, Peoples R China Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China Northwest A&F Univ, Coll Vet Med, Yangling, Shaanxi, Peoples R China Chinese Acad Sci, Shenzhen Inst Adv Technol, Ctr Biomed Mat & Interfaces, Shenzhen, Peoples R China Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China |
| Keywords | DHA Brain Absorption Fetus Encapsulation |
| Issue Date | 2019 |
| Publisher | NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE |
| Abstract | Docosahexaenoic acid (DHA) is one omega-3 fatty acid that is essential for the development and function of the brain. However, a large number of clinical trials found that the DHA supplementation showed no advantage on mental and motor skill development in term infants. A strategy based on DHA nanoencapsulation (nano FO) using an edible plant protein, zein, mimicking the milk structure is applied for enhanced maternal and fetal absorptions of DHA to improve early brain development. The nano FO achieved increased absorption in GI tract, enhanced delivery to the maternal, fetal, and offspring brains, and reduced fatty acid accumulation in the fetal liver. In the behavior assessments, the nano FO diet showed enhanced learning and memory improvement compared to the normal FO diet. It indicated that zein nanoencapsulation is with high potential for drug and nutrient deliveries to brain and through placenta to fetus with no toxicity concern. (C) 2018 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/552449 |
| ISSN | 1549-9634 |
| DOI | 10.1016/j.nano.2018.09.006 |
| Indexed | SCI(E) |
| Appears in Collections: | 深圳医院 |
