| Title | Linked anatomical and functional brain alterations in children with attention-deficit/hyperactivity disorder |
| Authors | Wu, Zhao-Min Llera, Alberto Hoogman, Martine Cao, Qing-Jiu Zwiers, Marcel P. Bralten, Janita An, Li Sun, Li Yang, Li Yang, Bin-Rang Zang, Yu-Feng Franke, Barbara Beckmann, Christian F. Mennes, Maarten Wang, Yu-Feng |
| Affiliation | Shenzhen Childrens Hosp, Shenzhen, Peoples R China Peking Univ, Hosp 6, Inst Mental Hlth, Natl Clin Res Ctr Mental Disorders, Beijing 100191, Peoples R China Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100191, Peoples R China Radboud Univ Nijmegen, Dept Human Genet, Med Ctr, Nijmegen, Netherlands Donders Inst Brain Cognit & Behav, Nijmegen, Netherlands Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China Hangzhou Normal Univ, Affiliated Hosp, Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China Radboud Univ Nijmegen, Donders Inst Brain Cognit & Behav, Dept Psychiat, Med Ctr, Nijmegen, Netherlands |
| Issue Date | 2019 |
| Publisher | NEUROIMAGE-CLINICAL |
| Abstract | Objectives: Neuroimaging studies have independently demonstrated brain anatomical and functional impairments in participants with ADHD. The aim of the current study was to explore the relationship between structural and functional brain alterations in ADHD through an integrated analysis of multimodal neuroimaging data. Methods: We performed a multimodal analysis to integrate resting-state functional magnetic resonance imaging (MRI), structural MRI, and diffusion-weighted imaging data in a large, single-site sample of children with and without diagnosis for ADHD. The inferred subject contributions were fed into regression models to investigate the relationships between diagnosis, symptom severity, gender, and age. Results: Compared with controls, children with ADHD diagnosis showed altered white matter microstructure in widespread white matter fiber tracts as well as greater gray matter volume (GMV) in bilateral frontal regions, smaller GMV in posterior regions, and altered functional connectivity (FC) in default mode and frontoparietal networks. Age-related growth of GMV of bilateral occipital lobe, FC in frontal regions as well as age-related decline of GMV in medial regions seen in controls appeared reversed in children with ADHD. In the whole group, higher symptom severity was related to smaller GMV in widespread regions in bilateral frontal, parietal, and temporal lobes, as well as greater GMV in intracalcarine and temporal cortices. Conclusions: Through a multimodal analysis approach we show that structural and functional alterations in brain regions known to be altered in subjects with ADHD from unimodal studies are linked across modalities. The brain alterations were related to clinical features of ADHD, including disorder status, age, and symptom severity. |
| URI | http://hdl.handle.net/20.500.11897/551658 |
| ISSN | 2213-1582 |
| DOI | 10.1016/j.nicl.2019.101851 |
| Indexed | SCI(E) SSCI(E) EI |
| Appears in Collections: | 第六医院 |
