Institutional Repository of Peking University: Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial - 开云app体育

Title	Alirocumab Reduces Total Nonfatal Cardiovascular and Fatal Events The ODYSSEY OUTCOMES Trial
Authors	Szarek, Michael White, Harvey D. Schwartz, Gregory G. Alings, Marco Bhatt, Deepak L. Bittner, Vera A. Diaz, Rafael Edelberg, Jay M. Goodman, Shaun G. Hanotin, Corinne Harrington, Robert A. Jukema, J. Wouter Kimura, Takeshi Kiss, Robert Gabor Lecorps, Guillaume Mahaffey, Kenneth W. Moryusef, Angele Pordy, Robert Roe, Matthew T. Tricoci, Pierluigi Xavier, Denis Zeiher, Andreas M. Steg, Gabriel Schwartz, Gregory G. Steg, Ph. Gabriel Bhatt, Deepak L. Bittner, Vera A. Diaz, Rafael Goodman, Shaun G. Harrington, Robert A. Jukema, J. Wouter Szarek, Michael Zeiher, Andreas M. Tricoci, Pierluigi Roe, Matthew T. Mahaffey, Kenneth W. Edelberg, Jay M. Hanotin, Corinne Lecorps, Guillaume Moryusef, Angele Pordy, Robert Sasiela, William J. Tamby, Jean-Francois Aylward, Philip E. Drexel, Heinz Sinnaeve, Peter Dilic, Mirza Gotcheva, Nina N. Goodman, Shaun G. Prieto, Juan-Carlos Yong, Huo Lopez-Jaramillo, Patricio Pecin, Ivan Reiner, Zeljko Ostadal, Petr Poulsen, Steen Hvitfeldt Viigimaa, Margus Nieminen, Markku S. Danchin, Nicolas Chumburidze, Vakhtang Marx, Nikolaus Liberopoulos, Evangelos Valdovinos, Pablo Carlos Montenegro Tse, Hung-Fat Kiss, Robert Gabor Xavier, Denis Zahger, Doron Valgimigli, Marco Kimura, Takeshi Kim, Hyo Soo Kim, Sang-Hyun Kedev, Sasko Erglis, Andrejs Laucevicius, Aleksandras Yusoff, Khalid Lopez, Ramos Ramos Lopez, Gabriel Arturo Alings, Marco Halvorsen, Sigrun Correa Flores, Roger M. Sy, Rody G. Budaj, Andrzej Morais, Joao Dorobantu, Maria Karpov, Yuri Ristic, Arsen D. Chua, Terrance Murin, Jan Fras, Zlatko Dalby, Anthony J. Tunon, Jose de Silva, H. Asita Hagstrom, Emil Muller, Christian Chiang, Chern-En Sritara, Piyamitr Guneri, Sema Parkhomenko, Alexander Ray, Kausik K. Moriarty, Patrick M. Roe, Matthew T. Chaitman, Bernard Kelsey, Sheryl F. Olsson, Anders G. Rouleau, Jean-Lucien Simoons, Maarten L. Alexander, Karen Meloni, Chiara Rosenson, Robert Sijbrands, Eric J. G. Alexander, John H. Armaganijan, Luciana Bagai, Akshay Bahit, Maria Cecilia Brennan, J. Matthew Clifton, Shaun DeVore, Adam D. Deloatch, Shalonda Dickey, Sheila Dombrowski, Keith Ducrocq, Gregory Eapen, Zubin Endsley, Patricia Eppinger, Arleen Harrison, Robert W. Hess, Connie Ng Hlatky, Mark A. Jordan, Joseph Dedrick Knowles, Joshua W. Kolls, Bradley J. Kong, David F. Leonardi, Sergio Lillis, Linda Maron, David J. Marcus, Jill Mathews, Robin Mehta, Rajendra H. Mentz, Robert J. Moreira, Humberto Graner Patel, Chetan B. Pereira, Sabrina Bernardez Perkins, Lynn Povsic, Thomas J. Puymirat, Etienne Jones, William Schuyler Shah, Bimal R. Sherwood, Matthew W. Stringfellow, Kenya Sujjavanich, Darin Toma, Mustafa Van Diepen, Sean F. P. Wilson, Matthew D. Yan, Andrew Tze-Kay Lopes, Renato D. Trotter, Charlene Schiavi, Lilia B. Garrido, Marcelo Alvarisqueta, Andres F. Sassone, Sonia A. Bordonava, Anselmo P. Alves De Lima, Alberto E. Schmidberg, Jorge M. Duronto, Ernesto A. Caruso, Orlando C. Novaretto, Leonardo P. Angel Hominal, Miguel Montana, Oscar R. Caccavo, Alberto Gomez Vilamajo, Oscar A. Lorenzatti, Alberto J. Cartasegna, Luis R. Paterlini, Gustavo A. Mackinnon, Ignacio J. Caime, Guillermo D. Amuchastegui, Marcos Salomone, Rodolfo Codutti, Oscar R. Jure, Horacio O. Bono, Julio O. E. Hrabar, Adrian D. Vallejos, Julio A. Ahuad Guerrero, Rodolfo A. Novoa, Federico Patocchi, Cristian A. Zaidman, Cesar J. Giuliano, Maria E. Dran, Ricardo D. Vico, Marisa L. Carnero, Gabriela S. Guzman, Pablo N. Medrano Allende, Juan C. Garcia Brasca, Daniela F. Bustamante Labarta, Miguel H. Nani, Sebastian Blumberg, Eduardo D. S. Colombo, Hugo R. Liberman, Alberto Luciardi, Hector L. Waisman, Gabriel D. Berli, Mario A. Duran, Ruben O. Garcia Cestari, Horacio G. Luquez, Hugo A. Giordano, Jorge A. Saavedra, Silvia S. Zapata, Gerardo Costamagna, Osvaldo Llois, Susana Waites, Jonathon H. Collins, Nicholas Soward, Allan Aylward, Philip E. Hii, Chris L. S. Shaw, James Arstall, Margaret A. Horowitz, John Rogers, James F. Colquhoun, David Oqueli Flores, Romulo E. Roberts-Thomson, Philip Raffel, Owen Lehman, Sam J. Aroney, Constantine Coverdale, Steven G. M. Garrahy, Paul J. Starmer, Gregory Sader, Mark Carroll, Patrick A. Dick, Ronald Zweiker, Robert Hoppe, Uta Huber, Kurt Berger, Rudolf Weidinger, Franz Faes, Dirk Hermans, Kurt Pirenne, Bruno Leone, Attilio Hoffer, Etienne Vrolix, Mathias C. M. De Wolf, Luc Wollaert, Bart Castadot, Marc Dujardin, Karl Beauloye, Christophe Vervoort, Geert Striekwold, Harry Convens, Carl Roosen, John Barbato, Emanuele Claeys, Marc Cools, Frank Terzic, Ibrahim Barakovic, Fahir Midzic, Zlatko Pojskic, Belma Fazlibegovic, Emir Durak-Nalbantic, Azra Vulic, Dusko Muslibegovic, Adis Goronja, Boris Reis, Gilmar Sousa, Luciano Nicolau, Jose C. Giorgeto, Flavio E. Silva, Ricardo P. Maia, Lilia Nigro Rech, Rafael Rossi, Paulo R. F. Cerqueira, Maria Jose A. G. Duda, Norberto Kalil, Renato Kormann, Adrian Abrantes, Jose Antonio M. Pimentel Filho, Pedro Soggia, Ana Priscila de Santos, Mayler O. N. Neuenschwander, Fernando Bodanese, Luiz C. Michalaros, Yorghos L. Eliaschewitz, Freddy G. Vidotti, Maria H. Leaes, Paulo E. Botelho, Roberto V. Kaiser, Sergio Fernandes Manenti, Euler Roberto F. Precoma, Dalton B. Moura Jorge, Jose C. Silva, Pedro G. M. de B. Silveira, Jose A. Saporito, Wladmir Marin Neto, Jose A. Feitosa, Gilson S. Ritt, Luiz Eduardo F. de Souza, Juliana A. Costa, Fernando Souza, Weimar K. S. B. Reis, Helder J. L. Machado, Leandro Aidar Ayoub, Jose Carlos Todorov, Georgi V. Nikolov, Fedya P. Velcheva, Elena S. Tzekova, Maria L. Benov, Haralambi O. Petranov, Stanislav L. Tumbev, Haralin S. Shehova-Yankova, Nina S. Markov, Dimitar T. Raev, Dimitar H. Mollov, Mihail N. Kichukov, Kostadin N. Ilieva-Pandeva, Katya A. Ivanova, Raya Mincheva, Valentina M. Lazov, Petar V. Dimov, Bojidar I. Senaratne, Manohara Stone, James Kornder, Jan Pearce, Stephen Dion, Danielle Savard, Daniel Pesant, Yves Pandey, Amritanshu Robinson, Simon Gosselin, Gilbert Vizel, Saul Hoag, Gordon Bourgeois, Ronald Morisset, Anne Sabbah, Eric Sussex, Bruce Kouz, Simon MacDonald, Paul Diaz, Ariel Michaud, Nicolas Fell, David Leung, Raymond Vuurmans, Tycho Lai, Christopher Nigro, Frank Davies, Richard Nogareda, Gustavo Vijayaraghavan, Ram Ducas, John Lepage, Serge Mehta, Shamir Cha, James Dupuis, Robert Fong, Peter Rodes-Cabau, Josep Fadlallah, Hussein Cleveland, David Thao Huynh Bata, Iqbal Hameed, Adnan Pincetti, Cristian Potthoff, Sergio Prieto, Juan C. Acevedo, Monica Aguirre, Arnoldo Vejar, Margarita Yanez, Mario Araneda, Guillermo Fernandez, Mauricio Perez, Luis Varleta, Paola Florenzano, Fernando Huidobro, Laura Raffo, Carlos A. Olivares, Claudia Nahuelpan, Leonardo Montecinos, Humberto Chen, Jiyan Dong, Yugang Huang, Weijian Wang, Jianzhong Huang, Shi'An Yao, Zhuhua Li, Xiang Cui, Lan Lin, Wenhua Sun, Yuemin Wang, Jingfeng Li, Jianping Zhang, Xuelian Zhu, Hong Chen, Dandan Huang, Lan Dong, Shaohong Su, Guohai Xu, Biao Su, Xi Cheng, Xiaoshu Lin, Jinxiu Zong, Wenxia Li, Huanming Feng, Yi Xu, Dingli Yang, Xinchun Ke, Yuannan Lin, Xuefeng Zhang, Zheng Zheng, Zeqi Luo, Zhurong Chen, Yundai Ding, Chunhua Zheng, Yang Li, Xiaodong Peng, Daoquan Li, Ying Wei, Meng Liu, Shaowen Yu, Yihua Qu, Baiming Jiang, Weihong Zhou, Yujie Zhao, Xingsheng Yuan, Zuyi Guo, Ying Xu, Xiping Shi, Xubo Ge, Junbo Fu, Guosheng Bai, Feng Fang, Weiyi Shou, Xiling Yang, Xiangjun Wang, Jian'An Sun, Yingxian Lu, Qinghua Zhang, Ruiyan Zhu, Jianhua Xu, Yizhou Fan, Zhongcai Li, Tianchang Wu, Chun Jaramillo, Nicolas Vallejo, Gregorio Sanchez Botia, Diana C. Luna Lopez, Rodrigo Botero De Salazar, Dora I. Molina Bonfanti, Alberto J. Cadena Higuera, Juan Diego Silva, Sandra I. Barrera Lozada, Henry J. Garcia Arroyo, Julian A. Coronel Mendoza, Jose L. Accini Ruiz, Ricardo L. Fernandez Jatin, Fernando G. Manzur Herazo, Aristides Sotomayor Parada, Jeffrey Castellanos Triana, Miguel A. Urina Strozzi, Maja Car, Sinisa Milicic, Davor Bencic, Martina Lovric Pintaric, Hrvoje Prvulovic, Deiti Sikic, Jozica Persic, Viktor Mileta, Dean Stambuk, Kresimir Zdravko, Babic Tomulic, Vjekoslav Krstulovic, Stanka Mejic Starcevic, Boris Spinar, Jindrich Horak, David Stasek, Josef Alan, David Machova, Vilma Linhart, Ales Novotny, Vojtech Kaucak, Vladimir Rokyta, Richard Naplava, Robert Coufal, Zdenek Adamkova, Vera Podpera, Ivo Zizka, Jiri Motovska, Zuzana Marusincova, Ivana Svab, Premysl Ostadal, Petr Heinc, Petr Kuchar, Jiri Povolny, Petr Matuska, Jiri Raungaard, Bent Clemmensen, Peter Bang, Lia E. May, Ole Bottcher, Morten Hove, Jens D. Frost, Lars Gislason, Gunnar Larsen, John Johansen, Peter Betton Hald, Flemming Jeppesen, Jorgen Nielsen, Tonny Kristensen, Kjeld S. Walichiewicz, Piotr Maria Lomholdt, Jens D. Klausen, Ib C. Nielsen, Peter Kaiser Davidsen, Flemming Videbaek, Lars Soots, Mai Vahula, Veiko Hedman, Anu Soopold, Ullar Martsin, Kaja Kristjan, Arved Taskinen, Marja-Riitta Porthan, Kimmo Airaksinen, Juhani K. Juonala, Markus Kiviniemi, Tuomas Vikman, Saila Posio, Pirjo Taurio, Jyrki Huikuri, Heikki Kaikkonen, Kari Coste, Pierre Ferrari, Emile Morel, Olivier Montalescot, Gilles Barone-Rochette, Gilles Mansourati, Jacques Cottin, Yves Leclercq, Florence Belhassane, Abdelkader Delarche, Nicolas Boccara, Franck Paganelli, Franck Clerc, Jerome Schiele, Francois Aboyans, Victor Probst, Vincent Berland, Jacques Lefevre, Thierry Citron, Bernard Khintibidze, Irakli Shaburishvili, Tamaz Pagava, Zurab Ghlonti, Ramaz Lominadze, Zaza Khabeishvili, George Hemetsberger, Rayyan Rauch-Kroehnert, Ursula Stratmann, Matthias Appel, Karl-Friedrich Schmidt, Ekkehard Omran, Heyder Stellbrink, Christoph Dorsel, Thomas Lianopoulos, Emmanouil Marx, Roger Zirlik, Andreas Schellenberg, Detlev Heitzer, Thomas Laufs, Ulrich Marx, Nikolaus Gielen, Stephan Winkelmann, Bernhard Behrens, Steffen Sydow, Karsten Simonis, Gregor Muenzel, Thomas Werner, Nikos Leggewie, Stefan Boecker, Dirk Braun-Dullaeus, Ruediger Toursarkissian, Nicole Jeserich, Michael Weissbrodt, Matthias Schaeufele, Tim Weil, Joachim Voeller, Heinz Waltenberger, Johannes Natour, Mohammed Schmitt, Susanne Steiner, Stephan Heidenreich, Lothar Gremmler, Uwe Killat, Holger Rieker, Werner Patsilinakos, Sotiris Kartalis, Athanasios Manolis, Athanassios Sionis, Dimitrios Liberopoulos, Evangelos Skoumas, Ioannis Athyros, Vasilios Vardas, Panagiotis Parthenakis, Frangkiskos Alexopoulos, Dimitrios Hahalis, Georgios Lekakis, John Hatzitolios, Apostolos Ovando, Sergio R. Fausto Valdovinos, Pablo Carlos Montenegro Benecke, Juan L. Arango De Leon, Edgar R. Rodriguez Yan, Bryan P. Y. Siu, David C. W. Turi, Tibor Merkely, Bela Kiss, Robert Gabor Ungi, Imre Lupkovics, Geza Nagy, Lajos Katona, Andras Edes, Istvan Muller, Gabor Horvath, Ivan Kapin, Tibor Falukozy, Jozsef Kumbla, Mukund Sandhu, Manjinder Annam, Sharath Proddutur, Naveen Reddy Premchand, Rajendra K. Mahajan, Ajaykumar Abhyanakar, Atul D. Kerkar, Prafulla Govinda, Ravishankar A. Oomman, Abraham Sinha, Dhurjati Patil, Sachin N. Kahali, Dhiman Sawhney, Jitendra Joshi, Abhijeet B. Chaudhary, Sanjeev Harkut, Pankaj Guha, Santanu Porwal, Sanjay Jujjuru, Srimannarayana Pothineni, Ramesh B. Monteiro, Minguel R. Khan, Aziz Iyengar, Shamanna S. Grewal, Jasprakash Singh Chopda, Manoj Fulwani, Mahesh C. Patange, Aparna Chopra, Vijay K. Goyal, Naresh K. Shinde, Rituparna Manakshe, Gajendra V. Patki, Nitin Sethi, Sumeet Munusamy, Vengatesh Karna, Sunil Adhyapak, Srilakshmi Pandurangi, Ulhas Mathur, Rishabh Kalashetti, Suhas Bhagwat, Ajit Raghuraman, Bagirath Yerra, Shiv Kumar Bhansali, Prasant Borse, Rohidas Das, Srihari Abdullakutty, Jabir Saathe, Shireesh Palimkar, Priya Abdullkutty, Jabir Sathe, Shireesh Palimkar, Priya Atar, Shaul Shechter, Michael Mosseri, Morris Arbel, Yaron Lotan, Chaim Rosenschein, Uri Katz, Amos Henkin, Yaakov Francis, Adi Klutstein, Marc Nikolsky, Eugenia Turgeman, Yoav Halabi, Majdi Kornowski, Ran Jonas, Michael Amir, Offer Rozenman, Yoseph Fuchs, Shmuel Hussein, Osamah Gavish, Dov Vered, Zvi Caraco, Yoseph Elias, Mazen Tov, Naveh Lishner, Michael Elias, Nizar Piovaccari, Giancarlo De Pellegrin, Annamaria Guardigli, Gabriele Licciardello, Giovanni Auguadro, Carla Cuccia, Claudio Salvioni, Alessandro Musumeci, Giuseppe Calabro, Paolo Novo, Salvatore Faggiano, Pompilio De Cesare, Nicoletta B. Berti, Sergio Cavallini, Claudio Puccioni, Enrico Galvani, Marcello Tespili, Maurizio Piatti, Piermarco Palvarini, Michela De Luca, Giuseppe Violini, Roberto De Leo, Alessandro Filardi, Pasquale Perrone Ferratini, Maurizio Ricca, Vittorio Dai, Kazuoki Kamiya, Haruo Ando, Kenji Takeda, Yoshihiro Morino, Yoshihiro Hata, Yoshiki Kimura, Kazuo Kishi, Koichi Michishita, Ichiro Uehara, Hiroki Higashikata, Toshinori Hirayama, Atsushi Hirooka, Keiji Sakagami, Satoru Taguchi, Shuichi Koike, Akihiro Fujinaga, Hiroyuki Koba, Shinji Kozuma, Ken Kawasaki, Tomohiro Ono, Yujiro Shimizu, Masatoshi Katsuda, Yousuke Wada, Atsuyuki Shinke, Toshiro Kimura, Takeshi Ako, Junya Fujii, Kenshi Takahashi, Toshiyuki Sakamoto, Tomohiro Furukawa, Yutaka Sugino, Hiroshi Mano, Toshiaki Utsu, Noriaki Ito, Kashima Haraguchi, Takuya Ueda, Yasunori Nishibe, Akira Fujimoto, Kazuteru Masutani, Motomaru Fujimoto, Kazuteru Yoon, Jung Han Kim, Sang-Hyun Park, Hun Sik Chae, In-Ho Kim, Moo Hyun Jeong, Myung Ho Rha, Seungwoon Kim, Chongjin Kim, Hyo-Soo Hong, Taekjong Tahk, Seung-Jea Kim, Youngkwon Busmane, Arija Pontaga, Natalija Strelnieks, Aldis Mintale, Iveta Sime, Iveta Petrulioniene, Zaneta Kavaliauskiene, Roma Jurgaitiene, Ruta Sakalyte, Gintare Slapikas, Rimvydas Norkiene, Sigute Misonis, Nerijus Kibarskis, Aleksandras Kubilius, Raimondas Bojovski, Stojko Kedev, Sasko Lozance, Nensi Kjovkaroski, Aleksandar Doncovska, Snezana Ong, Tiong Kiam Kasim, Sazzli Maskon, Oteh Kandasamy, Balachandran Yusoff, Khalid Liew, Houng B. Mohamed, Wan Mohd Izani Wan Garcia Castillo, Armando Carrillo Calvillo, Jorge Fajardo Campos, Pedro Nunez Fragoso, Juan Carlos Bayram Llamas, Edmundo Alfredo Alcocer Gamba, Marco Antonio Carranza Madrigal, Jaime Gonzalez Salas, Luis Gerardo Lopez Rosas, Enrique Gonzalez Diaz, Belinda Salcido Vazquez, Eduardo Nacoud Ackar, Alfredo Llamas Esperon, Guillermo Antonio Martinez Sanchez, Carlos Rodolfo Guerrero De Leon, Maria Suarez Otero, Rodrigo Fanghanel Salmon, Guillermo Perez Rios, Jesus Antonio Garza Ruiz, Jose Angel Breedveld, Robert W. Hoogslag, Pieter A. M. Suryapranata, Harry Oomen, Antonius Wiersma, Jacobijne J. Van Der Wal, Ruud M. A. Van Huysduynen-Monraats, Pascalle S. Hooft Karalis, Ioannis Verdel, Gerardus J. E. Brueren, Bart R. G. Troquay, Roland PTh Viergever, Eric P. Al-Windy, Nadea Y. Y. Bartels, Gerard L. Cornel, Jan H. Hermans, Walter R. M. Herrman, Johannes P. R. Bos, Robert J. Groutars, Reginald G. E. J. Van Der Zwaan, Coenraad C. Kaplan, Refik Ronner, Eelko Groenemeijer, Bjorn E. Bronzwaer, Patrick N. A. Liem, Anho A. H. Rensing, Bernard J. W. M. Bokern, Marcel J. J. A. Nijmeijer, Remco Hersbach, Ferry M. R. J. Willems, Frank F. Gosselink, Antonius T. M. Elliott, John Wilkins, Gerard Fisher, Raewyn Scott, Douglas Hart, Hamish Stewart, Ralph Harding, Scott Ternouth, Ian Fisher, Nicholas Aitken, Denise Anscombe, Russell Davidson, Laura Tomala, Tadeusz Nygard, Ottar Sparby, Jon Arne Andersen, Kjell Gullestad, Lars Jortveit, Jarle Munk, Peter S. Singsaas, Erlend Gyllensten Halvorsen, Sigrun Hurtig, Ulf Correa Flores, Roger M. Calderon Ticona, Jorge R. Durand Velasquez, Julio R. Negron Miguel, Sandra A. Sanabria Perez, Enrique S. Carrion Chambilla, Jesus M. Chavez Ayala, Carlos A. Castillo Leon, Reynaldo P. Vargas Gonzales, Rolando J. Hernandez Zuniga, Jose D. Camacho Cosavalente, Luis A. Bravo Mannucci, Jorge E. Heredia Landeo, Javier Llerena Navarro, Nassip C. Roldan Concha, Yudy M. Rodriguez Chavez, V-ctor E. Anchante Hernandez, Henry A. Zea Nunez, Carlos A. Mogrovejo Ramos, Walter Ferrolino, Arthur Sy, Rosa Allyn G. Tirador, Louie Sy, Rody G. Matiga, Generoso Coching, Raul Martin Bernan, Alisa Rogelio, Gregorio Morales, Dante D. Tan, Edgar Sulit, Dennis Jose Wlodarczak, Adrian Jaworska, Krystyna Skonieczny, Grzegorz Pawlowicz, Lidia Wojewod, Pawel Busz-Papiez, Benita Bednarski, Janusz Goch, Aleksander Staneta, Pawel Dulak, Elzbieta Budaj, Andrzej Saminsk, Krzysztof Krasowski, Wlodzimierz Sudnik, Wanda Zurakowski, Aleksander Skorski, Marcin Lysek, Roman Miklaszewicz, Beata Kubica, Jacek Lipko, Jan Andrzej Kostarska-Srokosz, Edyta Piepiorka, Marek Drzewiecka, Anna Sciborski, Ryszard Stasiewski, Arkadiusz Blicharski, Tomasz Bystryk, Leszek Szpajer, Michal Korol, Marek Czerski, Tomasz Mirek-Bryniarska, Ewa Gniot, Jacek Lubinski, Andrzej Gorny, Jerzy Franek, Edward Raczak, Grzegorz Szwed, Hanna Monteiro, Pedro Bastos, Jose Mesquita Pereira, Helder H. Martins, Dinis Morais, Joao Seixo, Filipe Mendonca, Carlos Botelho, Ana Minescu, Bogdan Istratoaie, Octavian Tesloianu, Dan N. Dorobantu, Maria Cristian, Gabriel Podoleanu, Cristian G. C. Constantinescu, Mircea C. A. Bengus, Cristina M. Militaru, Constantin Rosu, Doina Parepa, Irinel R. Matei, Adrian V. Alexandru, Tom M. Coman, Ioan Cioranu, Rodica Stanescu Dimulescu, Doina Shvarts, Yury Orlikova, Olga Kobalava, Zhanna Barbarash, Olga L. Markov, Valentin Lyamina, Nadezhda Gordienko, Alexander Zrazhevsky, Konstantin Vishnevsky, Alexander Y. Gurevich, Victor Stryuk, Raisa Lomakin, Nikita V. Bokarev, Igor Shalaev, Sergey Khaisheva, Larisa Chizhov, Petr Viktorova, Inna Osokina, Natalya Akatova, Evgenia Chumakova, Galina Libov, Igor Voevoda, Mikhail I. Tretyakova, Tatyana V. Baranov, Evgeny Shustov, Sergey Yakushin, Sergey Gordeev, Ivan Khasanov, Niiaz Reshetko, Olga Sotnikova, Tatiana Molchanova, Olga Nikolaev, Konstantin Gapon, Liudmila Baranova, Elena Shogenov, Zaur Kosmachova, Elena Karpov, Yuriy Karpov, Yuri Povzun, Anton Egorova, Liudmila Tyrenko, Vadim V. Ivanov, Igor G. Kanorsky, Sergey Simic, Dragan Ivanovic, Nikola Davidovic, Goran Tasic, Nebojsa Asanin, Milika R. Stojic, Stevo Apostolovic, Svetlana R. Ilic, Stevan Putnikovic, Biljana Stankovic, Aleksandar Arandjelovic, Aleksandra Radovanovic, Slavica Ristic, Arsen D. Balinovac, Jovan Dincic, Dragan V. Seferovic, Petar Dodic, Slobodan Dimkovic, Sinisa Poh, Kian-Keong Ong, Hean Yee Micko, Karol Nociar, Jan Pella, Daniel Fulop, Peter Hranai, Marian Palka, Juraj Mazur, Juraj Majercak, Ivan Dzupina, Andrej Fazekas, Frantisek Gonsorcik, Jozef Bugan, Viliam Selecky, Juraj Kamensky, Gabriel Strbova, Jaroslava Smik, Rudolf Dukat, Andrej Olexa, Peter Zuran, Ivan Poklukar, Janez Suligoj, Natasa Cerni Cevc, Matija Cyster, Henry P. Ranjith, Naresh Corbett, Clive Bayat, Junaid Makotoko, Ellen Makoali Kapp, Ilse E. Basson, Matthys M. de V. Lottering, Hanlie Van Zyl, Louis J. Sebastian, Peter J. Pillay, Thayabran Saaiman, Jan A. Commerford, Patrick J. Cassimjee, Soraya Ebrahim, Iftikhar O. Sarvan, Mahomed Mynhardt, Joseph H. Reuter, Helmuth Moodley, Rajendran Vida, Manuel Cequier Fillat, Angel R. Peris, Vicente Bodi Jimenez, Francisco Fuentes Marin, Francisco Cruz Fernandez, Jose M. Gil-Extremera, Blas Diz, Fernando Worner Garcia-Dorado, David Iniguez, Andres Tunon Fernandez, Jose Gonzalez-Juanatey, Jose R. Fernandez Portales, Javier Civeira Murillo, Fernando Matas Pericas, Laia Luis Zamorano, Jose De Mora Martin, Manuel Bruguera Cortada, Jordi Alonso Martin, Joaquin J. De Berrazueta Fernandez, Jose R. Diaz Fernandez, Jose Francisco Garcia Lledo, Jose Alberto Cosin Sales, Juan Botas Rodriguez, Javier Gusi Tragant, Gabriel Benedicto, Amparo Gonzalez-Juanatey, Carlos Camprubi Potau, Mercedes Plaza Perez, Ignacio Moris De La Tassa, Cesar Loma-Osorio Rincon, Pablo Balaguer Recena, Javier Escudier, Juan M. Coca Payeras, Antonio Alonso Orcajo, Norberto Valdivielso, Pedro Constantine, Godwin Haniffa, Ruvaiz Tissera, Nirmali Amarasekera, Stanley Fernando, Nimali Jayawardena, Jayanthimala Santharaj, Wijeyasingam Ekanayaka, Ruvan Mendis, Sepalika Senaratne, Vajira Mayurathan, Gnanamoorthy Sirisena, Thilak Rajapaksha, Ajantha Herath, Jagath I. Amarasena, Naomali Berglund, Stefan Rasmanis, Gundars Witt, Nils Mourtzinis, Georgios Nicol, Peter Hansen, Ole Romeo, Stefano Jensen, Steen Agergaard Torstensson, Ingemar Ahremark, Ulf Sundelin, Torbjorn Moccetti, Tiziano Muller, Christian Mach, Francois Binder, Ronald Tsai, Wei-Chuan Ueng, Kwo-Chang Lai, Wen-Ter Liu, Ming-En Hwang, Juey-Jen Yin, Wei-Hsian Hsieh, I-Chang Lin, Wei Hsiang Kuo, Jen-Yuan Huang, Tsuei-Yuan Fang, Chih-Yuan Kaewsuwanna, Pinij Soonfuang, Wasant Jintapakorn, Woravut Sukonthasarn, Apichard Wongpraparut, Nattawut Sastravaha, Krisada Sansanayudh, Nakarin Kehasukcharoen, Wirash Piyayotai, Dilok Chotnoparatpat, Paiboon Camsari, Ahmet Kultursay, Hakan Mutlu, Bulent Ersanli, Murat Demirtas, Mustafa Kirma, Cevat Ural, Ertan Koldas, Lale Karpenko, Oleksandr Prokhorov, Alexander Vakaluyk, Ihor Myshanych, Halyna Reshotko, Dmytro Batushkin, Valeriy Rudenko, Leonid Kovalskyi, Ihor Kushnir, Mykola Tseluyko, Vira Mostovoy, Yuriy Stanislavchuk, Mykola Kyiak, Yulian Karpenko, Yuriy Malynovsky, Yaroslav Klantsa, Andriy Kutniy, Oles Amosova, Ekaterina Tashchuk, Viktor Leshchuk, Oleh Rishko, Mykola Kopytsya, Mykola Yagensky, Andriy Vatutin, Mykola Bagriy, Andriy Barna, Olga M. Ushakov, Olexiy Dzyak, Georgiy Goloborodko, Borys Rudenko, Anatolii Zheleznyy, Volodymyr Trevelyan, Jasper Zaman, Azfar Lee, Kaeng Moriarty, Andrew Aggarwal, Rajesh K. Clifford, Piers Wong, Yuk-Ki Iqbal, Syed M. R. Subkovas, Eduardas Braganza, Denise Sarkar, David Storey, Robert Griffiths, Huw Mcclure, Sam Muthusamy, Rangasamy Kurian, John Levy, Terry Barr, Craig Kadr, Honer Gerber, Robert Simaitis, Audrius Soran, Handrean Mathur, Anthony Brodison, Adrian Oliver, Richard Mudawi, Telal Reynolds, Timothy Sharman, David Butler, Rob Wilkinson, Peter Lip, Gregory Y. H. Halcox, Julian Vardi, Gil Baldari, Duccio Brabham, David Treasure, Charles, II Dahl, Charles Palmer, Bruce Wiseman, Alan Khan, Abul Puri, Sanjeev Mohart, Ann Elizabeth Ince, Carlos Flores, Enrique Wright, Scott Cheng, Shi-Chi Rosenberg, Michael Rogers, William, Jr. Kosinski, Edward Forgosh, Les Waltman, Jonathan Khan, Misal Shoukfeh, Mohammad Dagher, Georges Lieber, Ira Kumar, Priya East, Cara Krichmar, Perry White, Lindsey Knickelbine, Thomas Haldis, Thomas Gillespie, Eve Suh, David Arif, Imran Akhter, Faiq Carlson, Eric D'Urso, Michael El-Ahdab, Fadi Nelson, William Harris, Barry Cohen, Steven Carter, Luther Sabatino, Kenneth Haddad, Tariq Malik, Amir Rao, Sunder Mulkay, Angel Jovin, Ion Klancke, Kim Malhotra, Vinay Devarapalli, Sai K. Koren, Michael Chandna, Harish Dodds, George, III Janik, Matthew Moran, Joseph Sumner, Andrew Kobayashi, John Davis, William Yazdani, Shahram Pasquini, John Thakkar, Maitreya Vedere, Amarnath Leimbach, Wayne Rider, James Singh, Narendra Shah, Anil V. Janosik, Denise Pepine, Carl Berman, Brett Gelormini, Joseph Daniels, Christopher Keating, Friederike Kondo, Nicholas I. Shetty, Sanjay Waider, Winfried Takata, Theodore Abu-Fadel, Mazen Shah, Vipul Aggarwal, Rahul Izzo, Mark Kumar, Anil Hattler, Brack Link, Chad Bortnick, Anna Kinzfogl, George, III Ghitis, Arnold Larry, John Teufel, Edward Kuhlman, Peter Mclaurin, Brent Zhang, Wenwu Thew, Stephen Abbas, Jalal White, Matthew Ranadive, Nandkishore Gring, Christian Henderson, David Schuchard, Timothy Farhat, Naim Kline, Geoffrey Mahal, Sharan Whitaker, Jack Speirs, Shawn Andersen, Rolf Daboul, Nizar Horwitz, Phillip Ponce, George Jafar, Zubair Mcgarvey, Joseph, Jr. Panchal, Vipul Voyce, Stephen Blok, Thomas Sheldon, William Azizad, Masoud M. Schmalfuss, Carsten Picone, Mark Herzog, William, Jr. Lindsey, Jason Nowins, Rosemary Lepor, Norman El Shahawy, Mahfouz Weintraub, Howard Irimpen, Anand May, Wade Galski, Thomas Chu, Alan Mody, Freny Hodes, Zachary Rose, Gregory Fairlamb, James Lambert, Charles, Jr. Raisinghani, Ajit Abbate, Antonio King, Marilyn Carey, Charles Gerber, Jaime Younis, Liwa Park, Hyeun (Tom) Vidovich, Mladen Knutson, Thomas Friedman, Dennis Chaleff, Fred Loussararian, Arthur Rozeman, Phillip Kimmelstiel, Carey Silver, Kevin Foster, Malcolm Tonnessen, Glen Amlani, Mohamadali Wali, Andreas Malozzi, Christopher Wattanakit, Keattiyoat O'Donnell, Philip J. Singal, Dinesh Jaffrani, Naseem Banuru, Sridhar Fisher, Daniel Xenakis, Mark Perlmutter, Neal Bhagwat, Ravi Strader, James, Jr. Akyea-Djamson, Ayim Labroo, Ajay Lee, Kwan Marais, H. John Claxton, Edmund, Jr. Berk, Martin Rossi, Peter Joshi, Parag Khaira, Ajit S. Kumkumian, Greg Lupovitch, Steven Purow, Joshua Welka, Stephen Hoffman, David Fischer, Stuart Soroka, Eugene Eagerton, Donald Pancholy, Samir Ray, Michael Farrar, Michael Pollock, Stewart French, William J. Diamantis, Steve Gimple, Lawrence Neustel, Mark Schwartz, Steven Pereira, Edward Spriggs, Douglas Strain, Janet Vo, Anthony Chane, Majed Hall, Jason Vijay, Nampalli Lotun, Kapildeo Lester, F. Martin Nahhas, Ahed Pope, Theodore Nager, Paul Vohra, Rakesh Bashir, Riyaz Ahmed, Hinan Berlowitz, Michael Fishberg, Robert Barrucco, Robert Yang, Eric Radin, Michael Sporn, Daniel Eisenberg, Steven Landzberg, Joel Mcgough, Martin Turk, Samir Schwartz, Michael Sundram, P. Sandy Jain, Diwakar Zainea, Mark Bayron, Carlos Karlsberg, Ronald Lui, Henry Keen, William Westerhausen, Donald, Jr. Khurana, Sandeep Agarwal, Himanshu Birchem, Jessica Penny, William, Jr. Chang, Mark Murphy, Sherrill Murphy, Sherrill Schifferdecker, Branislav Gilbert, John M. Chalavarya, Gopal Eaton, Charles Schmedtje, John F., Jr. Christenson, Stuart Denham, Douglas Macdonell, Alexander Gibson, Paul Rahman, Aref Al Joundi, Tammam Conrad, Gary Kotha, Purushotham Love, Michael Giesler, Gregory Rubenstein, Howard Akright, Laura Krawczyk, Justine Wells, Terry Welker, James Foster, Robert Gilmore, Richard Anderson, Jay Jacoby, Douglas Harris, Bill Gardner, Geraldine Dandillaya, Ramprasad Vora, Kishor Kostis, John Hunter, John Laxson, David Ball, Eric Camp, Alan Lopes, Renato Egydio, Flavia Kawakami, Anelise Oliveira, Janaina Wozniak, Julianna Matthews, Alexander Ratky, Caroline Valiris, Janine Berdan, Lisa Hepditch, Anita Quintero, Kirby Rorick, Tyrus Westbrook, Melissa Pascual, Andrea Rovito, Carla Bezault, Madeleine Drouet, Elodie Simon, Tabassome Alsweiler, Caroline Luyten, Anne Aylward, Phil Butters, Julie Griffith, Liddy Shaw, Michelle Hagstrom, Emil Grunberg, Lena Islam, Shahidul Bregeault, Marie-France Bougon, Nathalie Faustino, Douglas Fontecave, Sylvie Murphy, Judith Tamby, Jean-Francois Verrier, Melanie Agnetti, Veronique Andersen, Dorthe Badreddine, Emmy Bekkouche, Mhamed Bouancheau, Cecile Brigui, Imane Brocklehurst, Maddy Cianciarulo, Joseph Devaul, Dawn Domokos, Szilvia Gache, Cecile Gobillot, Caroline Guillou, Severine Healy, Jan Heath, Megan Jaiwal, Gayatri Javierre, Carine Labeirie, Julien Monier, Myriam Morales, Ulises Mrabti, Asmaa Mthombeni, Bicky Okan, Betim Smith, Lucile Sheller, Jennifer Sopena, Sebastien Pellan, Valerie Benbernou, Fadela Bengrait, Nafissa Lamoureux, Maud Kralova, Katarina Scemama, Michel Bejuit, Raphael Coulange, Anthony Berthou, Christelle Repincay, Jerome Lorenzato, Christelle Etienne, Alexis Gouet, Valerie Loizeau, Virginie Normand, Mickael Ourliac, Anne Rondel, Christelle Adamo, Antony Beltran, Pascale Barraud, Pauline Dubois-Gache, Helene Halle, Benjamin Metwally, Lamia Mourgues, Maxime Sotty, Marc Vincendet, Marion Cotruta, Raluca Zhu Chengyue Fournie-Lloret, Dominique Morrello, Christine Perthuis, Aurelie Picault, Patrick Zobouyan, Isabelle
Affiliation	SUNY, Downstate Sch Publ Hlth, Brooklyn, NY USA Auckland City Hosp, Green Lane Cardiovasc Serv, Auckland, New Zealand Univ Colorado, Div Cardiol, Sch Med, Aurora, CO USA Amphia Ziekenhuis Molengracht, Breda, Netherlands Brigham & Womens Hosp, Heart & Vasc Ctr, 75 Francis St, Boston, MA 02115 USA Harvard Med Sch, Boston, MA USA Univ Alabama Birmingham, Div Cardiovasc Dis, Birmingham, AL 35294 USA Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan Natl Yang Ming Univ, Taipei, Taiwan Inst Cardiovasc Rosario, Estudios Cardiol Latinoamer, Rosario, Santa Fe, Argentina Sanofi, Bridgewater, MA USA Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada Univ Toronto, St Michaels Hosp, Toronto, ON, Canada Sanofi, Paris, France Stanford Univ, Dept Med, Stanford Ctr Clin Res, Stanford, CA 94305 USA Leiden Univ, Dept Cardiol, Med Ctr, Leiden, Netherlands Kyoto Univ, Grad Sch Med, Kyoto, Kyoto, Japan Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary Regeneron Pharmaceut Inc, 777 Old Saw Mill River Rd, Tarrytown, NY 10591 USA Duke Univ, Sch Med, Dept Med, Div Cardiol, Durham, NC 27706 USA Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA St Johns Med Coll, Dept Pharmacol, Bangalore, Karnataka, India St Johns Med Coll, Div Clin Res, Bangalore, Karnataka, India St Johns Res Inst, Dept Pharmacol, Bangalore, Karnataka, India St Johns Res Inst, Div Clin Res, Bangalore, Karnataka, India Goethe Univ, Dept Med 3, Frankfurt, Germany Hop Bichat Claude Bernard, AP HP, Paris, France Paris Diderot Univ, Sorbonne Paris Cite, FACT, INSERM U1148, Paris, France Royal Brompton Hosp, Imperial Coll, Natl Heart & Lung Inst, London, England Estudios Cardiol Latinoamer, Rosario, Argentina Flinders Univ S Australia, South Australian Hlth & Med Res Inst, Med Ctr, Adelaide, SA, Australia Landeskrankenhaus Feldkirch, Feldkirch, Austria UZ Leuven, Leuven, Belgium Univ Clin Ctr Sarajevo, Sarajevo, Bosnia & Herceg Duke Univ Med Ctr, Duke Clin Res Inst, Durham, NC USA MHAT Nat Cardiol Hosp EAD, Sofia, Bulgaria Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada Univ Chile, Hosp Clin, Santiago, Chile Peking Univ, First Hosp, Beijing, Peoples R China Fundac Oftalmol Santander FOSCAL, Floridablanca, Colombia Univ Zagreb, Univ Hosp Ctr Zagreb, Zagreb Sch Med, Zagreb, Croatia Univ Zagreb, Univ Ctr Zagreb, Sch Med, Zagreb, Croatia Na Homolce Hosp, Prague, Czech Republic Aarhus Univ Skejby, Aarhus, Denmark North Estonia Med Ctr, Tallinn, Estonia Heart & Lung Ctr, Div Cardiol, HUCH, Helsinki, Finland Hop Europeen Georges Pompidou, FACT, F CRIN network, Paris, France Chapidze Emergency Cardiol Ctr, Tbilisi, Georgia Univ Aachen, Aachen, Germany Univ Gen Hosp Ioannina, Ioannina, Greece Unidad Diagnost Cardiol, Clin privada, Guatemala City, Guatemala Univ Hong Kong, Queen Mary Hosp, Hong Kong, Peoples R China Magyar Honvedseg Egeszsegugyi Kozpont, Budapest, Hungary St Johns Med Coll, Bangalore, Karnataka, India Ben Gurion Univ Negev, Soroka Univ Med Ctr, Fac Hlth Sci, Beer Sheva, Israel Univ Ferrara, Unit Operativa Cardiologia, Ferrara, Italy Kyoto Univ Grad Sch Med, Kyoto, Kyoto, Japan Seoul Natl Univ Hosp, Seoul, South Korea SMG Seoul Natl Univ, Boramae Med Ctr, Seoul, South Korea Univ Clin Cardiol, Skopje, Macedonia Univ Latvia, Pauls Stradins Clin Univ Hosp, Riga, Latvia Vilnius Univ Hosp Santaros Klinikos, Vilnius, Lithuania Univ Teknologi MARA UiTM Selayang Campus, Batu Caves, Malaysia UCSI Univ, Kuala Lumpur, Malaysia Med Off, Guadalajara, Jalisco, Mexico Auckland City Hosp, Green Lane Cardiovascular Serv, Auckland, New Zealand Oslo Univ HF, Oslo, Norway Hosp Nacl IV Alberto Sabogal Sologuren, Callao, Peru Cardinal Santos Med Ctr, San Juan, PR USA Postgraduate Med Sch, Grochowski Hosp, Warsaw, Poland Ctr Hosp Leiria Pombal, Leiria, Portugal Clin Emergency Hosp Bucharest, Bucharest, Romania Russian Cardiol Sci Product Complex, Moscow, Russia Clin Ctr Serbia, Belgrade, Serbia Natl Heart Ctr, Singapore, Singapore Univ Nemocn Bratislava, Interna Klin 1, Bratislava, Slovakia Univ Med Ctr Ljubljana, Div Med, Dept Vasc Med, Prevent Cardiol Unit, Ljubljana, Slovenia Milpark Hosp, Johannesburg, South Africa Fdn Jimenez Diaz, Madrid, Spain Univ Kelaniya, Clin Trials Unit, Kelaniya, Sri Lanka Uppsala Univ, Dept Med Sci, Uppsala Clin Res Ctr, Uppsala, Sweden Univ Basel, Basel, Switzerland Natl Yang Ming Univ, Taipei Vet Gen Hosp, Gen Clin Res Ctr, Taipei, Taiwan Ramathibodi Hosp, Bangkok, Thailand Dokuz Eylul Univ Tip Fakultesi, Izmir, Turkey MD Strazhesko Inst Cardiol AMS Ukraine, Kiev, Ukraine Imperial Coll London, London, England Univ Kansas Med Ctr, Clin Pharmacol, Kansas City, KS USA Duke Clin Res Inst, Durham, NC USA Univ Colorado Denver, Denver, CO USA St Louis Univ, Ctr Hlth Outcomes Res, St Louis, MO USA Univ Pittsburgh, Grad Sch Publ Hlth, Pittsburgh, PA USA Linkoping Univ, Dept Med & Hlth, Linkoping, Sweden Univ Montreal, Inst Cardiol, Montreal, PQ, Canada Erasmus MC, Rotterdam, Netherlands Duke Univ, Duke Clin Res Inst, Durham, NC USA Duke Univ, Med Ctr, Duke Clin Res Inst, Durham, NC USA Mt Sinai Sch Med, New York, NY USA Duke Univ, Durham, NC USA Brazilian Clin Res Inst, Sao Paulo, Brazil Hop Bichat Claude Bernard, AP HP, Paris, France Univ Toronto, St Michaels Hosp, Toronto, ON, Canada Univ Colorado Denver, Denver, CO USA Univ N Carolina, Chapel Hill, NC USA Fondazione IRCCS Policlinico S Matteo, Pavia, Italy Hop Europeen Georges Pompidou, Paris, France Univ British Columbia, St Pauls Hosp, Vancouver, BC, Canada Univ Alberta, Canadian VIGOUR Ctr, Edmonton, AB, Canada Clin Prado, Cordoba, Argentina Clin Privada Prov, Merlo, Buenos Aires, DF, Argentina Ctr Investigac Med Mar Plata, Mar Del Plata, Buenos Aires, Argentina Consultorios Asoc Endocrinologia Inv Clin Aplicad, CABA, Buenos Aires, DF, Argentina Clin FUSAVIM Privada, Villa Maria, Cordoba, Argentina Inst Cardiovascular Buenos Aires Ciudad Buenos Ai, Buenos Aires, DF, Argentina Inst Med Aguero, Moron, Buenos Aires, DF, Argentina Fdn Favaloro Docencia Investigac Med, CABA, Buenos Aires, DF, Argentina Hosp Cent Mendoza, Mendoza, Argentina Sanatorio Santa Rosa, Santa Rosa, La Pampa, Argentina Ctr Investigac Clin Iitoral, Santa Fe, Santa Fe, Argentina Dim Clin Privada, Ramos Mejia, Buenos Aires, DF, Argentina Clin Coronel Suarez, Coronel Suarez, Buenos Aires, DF, Argentina Sanatorio San Martin SA, Venado Tuerto, Santa Fe, NM USA Inst Med DAMIC, Cordoba, Argentina Hosp Italiano Plata, La Plata, Buenos Aires, Argentina Hosp Italiano La Plata, La Plata, Buenos Aires, Argentina Investigac Clin Tucuman, San Miguel De Tucuman, Tucuman, Argentina Inst Investigac Clin, Mar Del Plata, Buenos Aires, Argentina Inst Diagnostico La Plata, La Plata, Buenos Aires, Argentina Hosp Privado Ctr Med Cordoba, Cordoba, Argentina Cordis Inst Corazon, Resistencia, Chaco, Argentina Clin Chutro S R L, Cordoba, Argentina Sanatorio Allende, Cordoba, Argentina Inst Investigac Clin Quilmes, Quilmes, Buenos Aires, Argentina Inst Cardiologia Corrientes, Corrientes, Argentina Corporacion Medica San Martin, San Martin, Buenos Aires, Argentina Consultorio Privado, San Isidro, Buenos Aires, Argentina Hosp Reg Espanol Bahia Blanca, Bahia Blanca, Buenos Aires, Argentina Ctr Investigac Prevenc Cardiovascular, CABA, Buenos Aires, Argentina Inst Med Fdn Estudios Clin, Rosario, Santa Fe, Argentina Sanatorio Mariano Pelliza, Olivos, Buenos Aires, Argentina Inst Investigac Clin Zarate, Zarate, Buenos Aires, Argentina IMEP Inst Med Elsa Perez, Ciudadela, Buenos Aires, Argentina Sanatorio San Francisco, Santiago Del Estero, Argentina Clin Maternidad Suizo Argentina, CABA, Buenos Aires, Argentina Hosp Italiano, Cordoba, Argentina Ctr Med Lebensohn, Buenos Aires, DF, Argentina Clin Olivos, Buenos Aires, DF, Argentina Medeos, CABA, Buenos Aires, Argentina Clin Colombo, Cordoba, Argentina Inst Privado Investigaciones Clin Cordoba, Cordoba, Argentina Ctr Modelo Cardiol, San Miguel De Tucuman, Tucuman, Argentina Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina Hosp Prov Dr Jose Maria Cullen, Santa Fe, Santa Fe, Argentina Inst Investigac Clin San Nicolas, San Nicolas, Buenos Aires, Argentina Sanatorio Guemes, CABA, Buenos Aires, Argentina Ctr Med Luquez, Cordoba, Argentina Clin Inst Med Adrogue, Almirante Brown, Buenos Aires, Argentina Sanatorio Parque SA, Salta, Argentina Inst Cardiovascular Rosario, Rosario, Santa Fe, Argentina Clin Parra Ctr Investigac Clin Rafaela, Santa Fe, Argentina Hosp Interzonal Gen Agudos Eva Peron, San Martin, Buenos Aires, Argentina Coffs Harbour Hlth Campus, Coffs Harbour, NSW, Australia John Hunter Hosp, New Lambton Hts, NSW, Australia Mildura Cardiol, Mildura, Victoria, Australia South Australian Hlth & Med Res Inst, Flinders Univ & Med Ctr, Adelaide, SA, Australia Calvary Clin, Bruce, Australia Alfred Hosp, Prahran, Vic, Australia Northern Cardiol & Specialist Clin, Elizabeth Vale, Australia Queen Elizabeth Hosp, Woodville, SA, Australia Gosford Hosp, Gosford, Australia Wesley Med Ctr, Auchenflower, Queensland, Australia Ballarat Hlth Services, Ballarat, Vic, Australia Royal Hobart Hosp, Hobart, Tas, Australia Prince Charles Hosp, Chermside, Queensland, Australia Adelaide Med Res, Adelaide, SA, Australia Holy Spirit Northside Hosp, Chermside, Qld, Australia Nambour Gen Hosp, Nambour, Qld, Australia Princess Alexandra Hosp, Woolloongabba, Qld, Australia Cairns Hosp, Cairns, Queensland, Australia St George Hosp, Kogarah, NSW, Australia Redcliffe Hosp, Redcliffe, Queensland, Australia Epworth Healthcare, Richmond, Vic, Australia Univ Klinikum Graz, Graz, Austria Univ Klinikum Salzburg, Salzburg, Austria Vorarlberg Inst Vaskulare Forsch VIVIT, Feldkirch, Austria Wilhelminenspital Stadt Wien, Vienna, Austria KH Barmherzigen Bruder Eisenstadt, Kardiol & Nephrol, Eisenstadt, Austria Krankenanstalt Rudolfstiftung Stadt Wien, Vienna, Austria Mariaziekenhuis Vzw, Overpelt, Belgium AZ St Lucas, Ghent, Belgium Clin St Pierre, Ottignies, Belgium CHU Tivoli, La Louviere, Belgium CHR Citadelle, Liege, Belgium UZ Leuven, Leuven, Belgium ZOL, Genk, Belgium Private Practice, Tienen, Belgium ZNA Stuivenberg, Antwerp, Belgium Clin St Jean, Brussels, Belgium AZ Delta, Roeselare, Belgium UCL St Luc, Brussels, Belgium AZ St Maarten, Mechelen, Belgium Heilig Hart Ziekenhuis, Mol, Belgium ZNA Middelheim, Antwerp, Belgium Imelda Hosp, Bonheiden, Belgium OL Vrouwziekenhuis Campus Aalst, Aalst, Belgium UZ Antwerpen, Edegem, Belgium AZ Klina, Brasschaat, Belgium Heart Ctr BH, Tuzla, Bosnia & Herceg Univ Med Ctr Tuzla, Tuzla, Bosnia & Herceg Cantonal Hosp Dr Irfan Ljubijank Bihac, Bihac, Bosnia & Herceg Cantonal Hosp Zenica, Zenica, Bosnia & Herceg Univ Clin Hosp Mostar, Mostar, Bosnia & Herceg Clin Ctr Banja Luka, Banja Luka, Bosnia & Herceg Reg Med Ctr Dr Safet Mujic, Mostar, Bosnia & Herceg CARDRESEARCH Cardiol Assistencial Pesquisa, Belo Horizonte, MG, Brazil Hosp Coracao Brasil, Brasilia, DF, Brazil INCOR Inst Coracao, Sao Paulo, Brazil Hosp Sao Francisco De Assis, Belo Horizonte, MG, Brazil Hosp Univ Walter Cantidio, Fortaleza, Ceara, Brazil Hosp Base Sao Jose do Rio Preto, Sao Paulo, Brazil Hosp Univ Ulbra, Canoas, Brazil Hosp Evangelico Curitiba, Curitiba, Parana, Brazil Inst Ensino Pesquisa Clin Ceara Ltda, Fortaleza, Ceara, Brazil Hosp Sao Vicente De Paulo, Passo Fundo, RS, Brazil Inst Cardiol Do Rio Grande Do Sul, Porto Alegre, RS, Brazil Hosp Santa Isabel, Soc Div Providencia, Blumenau, Santa Catarina, Brazil Santa Casa Misericordia Pelotas, Pelotas, RS, Brazil Hosp Nossa Senhora Conceicao, Porto Alegre, RS, Brazil Soc Beneficiente Senhoras Hosp Sirio Libane, Sao Paulo, Brazil Centro Cardiol & Radiol Intervencionista LTDA, Aparecida Goiania, Brazil Hosp Vera Cruz NUPEC, Belo Horizonte, MG, Brazil Hosp Sao Lucas PUCRS, Porto Alegre, RS, Brazil Inst Ensino Consultoria & Pesquisa Clin LTDA ME, Belo Horizonte, MG, Brazil CPCLIN, Sao Paulo, Brazil Clin LOEMA, Campinas, Brazil Santa Casa Porto Alegre, Porto Alegre, RS, Brazil Inst Coracao Triangulo, Uberlandia, MG, Brazil CCBR Brasil, Rio De Janeiro, Brazil IMV Inst Med Vasc Hosp Mae Deus, Porto Alegre, RS, Brazil Soc Hosp Angelina Caron, Campina Grande Do Sul, Parana, Brazil Santa Casa Curitiba, Curitiba, Parana, Brazil Esho Empresa Serv Hosp SA, Sao Paulo, Brazil Fac Med ABC CEMEC, Sao Bernardo Campo, Sao Paulo, Brazil Inst Molestias Cardiovasculares Tatui IMC, Tatui, Brazil HCFMRP, Ribeirao Preto, Brazil Hosp Santa Izabel, Santa Casa Misericordia Bahia, Salvador, BA, Brazil Hosp Cardio Pulmonar, Salvador, BA, Brazil Ctr Cardiol Clin & Pesquisa Dra Juliana Souza, Brasilia, DF, Brazil FGM Clin Paulista Doencas Cardiovasc, Sao Paulo, Brazil Barroso & Sebba Ltda, Goiania, Go, Brazil Hosp Clin Gaspar Vianna, Belem, Para, Brazil Univ Fed Sao Paulo UNIFESP EPM, Sao Paulo, Brazil Hosp Estadual Mario Covas, Santo Andre, Brazil Inst Molestias Cardiovasc, Sao Jose Do Rio Preto, Brazil 2 MHAT, Sofia, Bulgaria Univ Multiprofile Hosp Act Treatment Sveti Georgi, Plovdiv, Bulgaria Specialized Hosp Act Treatment Cardiol, Pleven, Bulgaria UMHAT Dr Georgi Stranski, Pleven, Bulgaria Multiprof Distr Hosp Active Treatment Dr St Cherk, Veliko Tarnovo, Bulgaria Multiprofile Hosp Act Treatment Burgas AD, Burgas, Bulgaria Specialized Hosp Act Cardio Treatment Cardiolife, Varna, Bulgaria MHAT Bratan Shukerov AD, Cardio Dept Inrtens Unite, Smoljan, Bulgaria UMHAT Tzaritza Yoanna ISUL EAD, Sofia, Bulgaria MHAT Sveti Vrach EOOD, Sandanski, Bulgaria First Multiprofile Hosp Act Treatment Sofia EAD, Sofia, Bulgaria MHAT Lyulin EAD, Dept Internal Dis, Sofia, Bulgaria MHAT Blagoevgrad AD, Blagoevgrad, Bulgaria MHAT Nat Cardiol Hosp EAD, Sofia, Bulgaria UMHAT Alexandrovska EAD, Sofia, Bulgaria NMT Hosp Tsar Boris III, Sofia, Bulgaria Multiprofile Hosp Act Treatment Pazardzhik AD, Pazardzhik, Bulgaria Fifth MHAT Sofia EAD, Sofia, Bulgaria Dr MPJ Senaratne Profess Corp, Edmonton, AB, Canada TotalCardiology, Calgary, AB, Canada Surrey Mem Hosp, Surrey, BC, Canada Ctr Hosp Beauce Etchemin, St Georges De Beauce, PQ, Canada CardioVasc HR, St Jean, PQ, Canada St Jerome Med Res Inc, St Jerome, PQ, Canada Cambridge Cardiac Care Ctr, Cambridge, ON, Canada Victoria Heart Inst Fdn, Victoria, BC, Canada Ctr Hosp Pierre Gardeur, Terrebonne, PQ, Canada Vizel Cardiac Res, Cambridge, ON, Canada Discovery Clin Serv, Victoria, BC, Canada GA Res Associates Ltd, Moncton, NB, Canada Ctr Sante & Serv Soc Haute Yamaska, Granby, PQ, Canada Ctr Depistage & Rech Cardiovasc Rive Sud, Longueuil, PQ, Canada Gen Hosp Hlth Sci Ctr, St John, NF, Canada Ctr Hosp Reg Lanaudiere, Joliette, PQ, Canada Cape Breton Reg Hosp, Sydney, NS, Canada Ctr Hosp Reg Trois Rivieres, Trois Rivieres, PQ, Canada Clin Cardiol Levis, Levis, PQ, Canada Newmarket Cardiol Res Grp, Newmarket, ON, Canada Royal Alexandra Hosp, Edmonton, AB, Canada Royal Columbian Hosp, New Westminster, BC, Canada Thunder Bay Reg Hlth Sci Ctr, Thunder Bay, ON, Canada Ottawa Heart Inst, Ottawa, ON, Canada Red Deer Reg Hosp Ctr, Red Deer, AB, Canada Scarborough Cardiol Res, Scarborough, ON, Canada St Boniface Gen Hosp, Winnipeg, MB, Canada Ctr Hosp Univ Sherbrooke, Hotel Dieu, Sherbrooke, PQ, Canada Hamilton Gen Hosp, Hamilton, ON, Canada Lakeridge Hlth Oshawa, Oshawa, ON, Canada Ctr Sante & Serv Soc Reg Thetford Rech, Thetford Mines, PQ, Canada St Johns Hosp, St John, NB, Canada Laval Hosp, Quebec Heart Inst, Quebec City, PQ, Canada Rech GCP Res, Montreal, PQ, Canada Penticton Reg Hosp, Penticton, BC, Canada Montreal Gen Hosp, Montreal, PQ, Canada Queen Elizabeth 2 Hlth Sci Ctr, Halifax, NS, Canada Med Profess Corp, St Catharines, ON, Canada Ctr Investigac Clin Cics, Temuco, Chile Corp Beneficencia Osorno, Osorno, Chile Hosp Clin Univ Chile, Santiago, Chile Ctr Investigaciones Clin Univ, Santiago, Chile Hosp Barros Luco, Santiago, Chile Hosp Salvador, Santiago, Chile Hosp Naval Almirante Nef Vina Del Mar, Vina Del Mar, Chile Hosp Clin Magallanes, Punta Arenas, Chile Clin Alemana Santiago, Santiago, Chile Hosp Clin Reg Dr Guillermo Grant Benavente, Concepcion, Chile Psicomed Clin & Res Grp, Santiago, Chile Biomed Res Grp, Santiago, Chile Clin Univ Catol Maule, Talca, Chile Estudios Clin Region Ltda, Vina Del Mar, Chile Hosp & CRS El Pino, Santiago, Chile Hosp Base Valdivia, Valdivia, Chile Complejo Asistencial Dr Sotero Del Rio, Santiago, Chile Guangdong Gen Hosp, Guangzhou, Peoples R China Sun Yat Sen Univ, Affiliated Hosp 1, Guangzhou, Peoples R China Wenzhou Med Univ, Affiliated Hosp 1, Wenzhou, Peoples R China Siping Cent Peoples Hosp, Siping, Peoples R China Guangdong Med Univ, Affiliated Hosp, Zhanjiang, Peoples R China Tianjin Union Med Ctr, Tianjin, Peoples R China Yanbian Univ Hosp, Yanji, Peoples R China TEDA Int Cardiovascular Hosp, Tianjin, Peoples R China Tianjin Med Univ, Gen Hosp, Tianjin, Peoples R China Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Guangzhou, Peoples R China Peking Univ, Hosp 1, Beijing, Peoples R China Peoples Hosp, Changchun, Peoples R China Xuzhou Med Coll, Affiliated Hosp, Xuzhou, Jiangsu, Peoples R China Guizhou Prov Peoples Hosp, Guiyang, Peoples R China Third Mil Med Univ, Xinqiao Hosp, Chongqing, Peoples R China Shenzhen Peoples Hosp, Shenzhen, Peoples R China Shandong Univ, Jinan Cent Hosp Affiliated, Jinan, Peoples R China NJMU, Nanjing Drum Tower Hosp, Affiliated Hosp, Nanjing, Peoples R China Wuhan Asian Heart Hosp, Wuhan, Peoples R China Nanchang Univ, Affiliated Hosp 2, Nanchang, Jiangxi, Peoples R China Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Peoples R China Third Peoples Hosp Hubei Prov, Wuhan, Peoples R China Tianjin 4th Ctr Hosp, Tianjin, Peoples R China Southeast Univ, Zhongda Hosp, Nanjing, Peoples R China Southern Med Univ, Nanfang Hosp, Guangzhou, Peoples R China Beijing Chaoyang Hosp, Beijing, Peoples R China China Japan Friendship Hosp, Beijing, Peoples R China Baotou Med Coll, Affiliated Hosp 1, Baotou, Peoples R China Lanzhou Univ, Hosp 1, Lanzhou, Peoples R China Nanchang Univ, Affiliated Hosp 1, Nanchang, Jiangxi, Peoples R China Fuzhou Gen Hosp Nanjing Mil Command, Fuzhou, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Beijing, Peoples R China China Aerosp Corp, Cent Hosp, Beijing, Peoples R China Jilin Univ, Hosp 1, Changchun, Peoples R China China Med Univ, Shengjing Hosp, Shenyang, Peoples R China Cent S Univ, Xiangya Hosp 2, Changsha, Peoples R China Shanghai East Hosp, Shanghai, Peoples R China Shanghai Sixth Peoples Hosp, Shanghai, Peoples R China Shanghai First Peoples Hosp, Shanghai, Peoples R China Zhejiang Hosp, Hangzhou, Peoples R China Zhejiang Prov Peoples Hosp, Hangzhou, Peoples R China Cent S Univ, Xiangya Hosp 3, Changsha, Peoples R China Capital Med Univ, Beijing Anzhen Hosp, Beijing, Peoples R China Inner Mongolia Peoples Hosp, Hohhot, Peoples R China Xi An Jiao Tong Univ, Affiliated Hosp 1, Xian, Peoples R China Hunan Prov Peoples Hosp, Changsha, Peoples R China First Peoples Hosp Yueyang, Yueyang, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China Zhejiang Univ, Sir Run Run Shaw Hosp, Hangzhou, Peoples R China Lanzhou Univ, Hosp 2, Lanzhou, Peoples R China Shanghai Jiao Tong Univ, Shanghai Chest Hosp, Shanghai, Peoples R China Shaanxi Prov Peoples Hosp, Xian, Peoples R China Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China Zhejiang Univ, Affiliated Hosp 2, Hangzhou, Peoples R China China Med Univ, Hosp 1, Shenyang, Peoples R China Shandong Univ, Hosp 2, Jinan, Peoples R China Shanghai Jiao Tong Univ, Ruijin Hosp Affiliated, Shanghai, Peoples R China Zhejiang Univ, Affiliated Hosp 1, Hangzhou, Peoples R China Hangzhou First Peoples Hosp, Hangzhou, Peoples R China Luzhou Med Coll, Affiliated Hosp, Luzhou, Peoples R China Navy Gen Hosp, Ctr Cardiol, Beijing, Peoples R China Peking Univ, Shenzhen Hosp, Shenzhen, Peoples R China Ctr Med Ejercicio & Rehabilitac Cardiaca, Medellin, Colombia Fdn Cardiomet Eje Cafetero CEQUIN, Armenia, Colombia Hosp Santa Clara, Bogota, Colombia IPS Rodrigo Botero SAS, Medellin, Colombia Asociac IPS Med Internistas Caldas, Manizales, Colombia Clin Costa Itda, Barranquilla, Colombia Fdn Oftalmolog FOSCAL, Bucaramanga, Colombia Caja Compensac Familiar CAFAM, Bogota, Colombia Fdn Ctr Investigaciones Biomed Riescard, Espinal, Colombia IPS Ctr Med Julian Coronel SA, Cali, Colombia IPS Ctr Cientifico Asistencial Jose Luis Quing, Barranquilla, Colombia Ctr Cardiovascular Colombiano, Valle 156073, Colombia Ctr Diagnostico Cardiol LTDA, Cartagena, Colombia Ctr Cardiovascular Aristides Sotomayor Santa L, Cartagena, Colombia SIMEDICS IPS SAS, Bogota, Colombia Fdn Caribe Investigac Biomed, Barranquilla, Colombia Clin Hosp Ctr Zagreb, Zagreb, Croatia Gen Hosp Varazdin, Varazhdin, Croatia Univ Hosp Ctr Zagreb, Zagreb, Croatia Univ Hosp Ctr, Sestre Milosrdnice, Zagreb, Croatia Gen Hosp Slavonski Brod, Slavonski Brod, Croatia Clin Hosp Sveti Duh, Zagreb, Croatia Thalassotherapia Opatija, Opatija, Croatia Clin Hosp Merkur, Zagreb, Croatia Special Hosp Med Rehab Krapinske Toplice, Krapinske Toplice, Croatia Clin Hosp Ctr, Sestre Milosrdnice, Zagreb, Croatia Clin Hosp Ctr Rijeka, Rijeka, Croatia Gen Hosp Dubrovnik, Dubrovnik, Croatia Clin Hosp Dubrava, Zagreb, Croatia FN Brno, Brno, Czech Republic Krajska Nemocnice Liberec As, Liberec, Czech Republic Fak Nemocnice Hradec Kralove, Hradec Kralove, Czech Republic Fak Nemocnice Motole, Prague, Czech Republic InterkardioML Sro, Interni Kardiol Ambulance, Marianske Lazne, Czech Republic Vseobecna Fak Nemocnice Praze, Prague, Czech Republic Nemocnice Pardubickeho Kraje As, Pardubice, Czech Republic Mestska Nemocnice Ostrava, Ostrava, Czech Republic Fak Nemocnice Plzen, Plzen, Czech Republic Ctr Pro Choroby Srdce Cev, Kromeriz, Czech Republic Krajska Nemocnice Tomase Bati As, Zlin, Czech Republic Inst Klin Expt Med, Prague, Czech Republic Oblastni Nemocnice Kladno As, Kladno, Czech Republic Thomayerova Nemocnice, Prague, Czech Republic Fak Nemocnice Kralovske Vinohrady, Prague, Czech Republic Kardio Sever Ro, Ceska Lipa, Czech Republic Kardiol Amb
Keywords	acute coronary syndrome alirocumab total events
Issue Date	2019
Publisher	JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
Abstract	BACKGROUND The ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) trial compared alirocumab with placebo, added to high-intensity or maximum-tolerated statin treatment, after acute coronary syndrome (ACS) in 18,924 patients. Alirocumab reduced the first occurrence of the primary composite endpoint and was associated with fewer all-cause deaths. OBJECTIVES This pre-specified analysis determined the extent to which alirocumab reduced total (first and subsequent) nonfatal cardiovascular events and all-cause deaths in ODYSSEY OUTCOMES. METHODS Hazard functions for total nonfatal cardiovascular events (myocardial infarction, stroke, ischemia-driven coronary revascularization, and hospitalization for unstable angina or heart failure) and death were jointly estimated, linked by a shared frailty accounting for patient risk heterogeneity and correlated within-patient nonfatal events. An association parameter also quantified the strength of the linkage between risk of nonfatal events and death. The model provides accurate relative estimates of nonfatal event risk if nonfatal events are associated with increased risk for death. RESULTS With 3,064 first and 5,425 total events, 190 fewer first and 385 fewer total nonfatal cardiovascular events or deaths were observed with alirocumab compared with placebo. Alirocumab reduced total nonfatal cardiovascular events (hazard ratio: 0.87; 95% confidence interval: 0.82 to 0.93) and death (hazard ratio: 0.83; 95% confidence interval: 0.71 to 0.97) in the presence of a strong association between nonfatal and fatal event risk. CONCLUSIONS In patients with ACS, the total number of nonfatal cardiovascular events and deaths prevented with alirocumab was twice the number of first events prevented. Consequently, total event reduction is a more comprehensive metric to capture the totality of alirocumab clinical efficacy after ACS. (c) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.
URI	http://hdl.handle.net/20.500.11897/550797
ISSN	0735-1097
DOI	10.1016/j.jacc.2018.10.039
Indexed	SCI(E)
Appears in Collections:	第一医院深圳医院

Files in This Work

There are no files associated with this item.

Web of Science®

0

Checked on Last Week

Scopus®

Checked on Current Time

百度学术™

0

Checked on Current Time

Google Scholar™

Check

Show full item record

License: See PKU IR operational policies.