| Title | AIE Featured Inorganic-Organic Core@Shell Nanoparticles for High-Efficiency siRNA Delivery and Real-Time Monitoring |
| Authors | He, Xuewen Yin, Feng Wang, Dongyuan Xiong, Ling-Hong Kwok, Ryan T. K. Gao, Peng Fei Zhao, Zheng Lam, Jacky W. Y. Yong, Ken-Tye Li, Zigang Tang, Ben Zhong |
| Affiliation | Hong Kong Univ Sci & Technol, Chinese Natl Engn Res Ctr Tissue Restorat & Recon, Div Life Sci, Dept Chem,Hong Kong Branch,Inst Adv Study,Kowloon, Clear Water Bay, Hong Kong, Peoples R China Hong Kong Univ Sci & Technol, Dept Chem & Biol Engn, Kowloon, Clear Water Bay, Hong Kong, Peoples R China Peking Univ, Shenzhen Grad Sch, Sch Chem Biol & Biotechnol, State Key Lab Chem Oncogen,Key Lab Chem Genom, Shenzhen 518055, Peoples R China HKUST Shenzhen Res Inst, Shenzhen 518057, Peoples R China Shenzhen Ctr Dis Control & Prevent, Shenzhen 518055, Peoples R China Nanyang Technol Univ, Sch Elect & Elect Engn, Singapore 639798, Singapore South China Univ Technol, State Key Lab Luminescent Mat & Devices, SCUT HKUST Joint Res Lab, Ctr Aggregat Induced Emiss, Guangzhou 510640, Guangdong, Peoples R China |
| Keywords | Aggregation-induced emission (AIE) nanocarrier siRNA real-time apoptosis |
| Issue Date | 2019 |
| Publisher | NANO LETTERS |
| Abstract | RNA interference (RNAi) is demonstrated as one of the most powerful technologies for sequence-specific suppression of genes in disease therapeutics. Exploration of novel vehicles for small interfering RNA (siRNA) delivery with high efficiency, low cytotoxicity, and self-monitoring functionality is persistently pursued. Herein, by taking advantage of aggregation-induced emission luminogen (AIEgen), we developed a novel class of Ag@AIE core@shell nanocarriers with regulable and uniform morphology. It presented excellent efficiencies in siRNA delivery, target gene knockdown, and cancer cell inhibition in vitro. What's more, an anticancer efficacy up to 75% was achieved in small animal experiments without obvious toxicity. Attributing to the unique AIE properties, real-time intracellular tracking of siRNA delivery and long-term tumor tissue imaging were successfully realized. Compared to the commercial transfection reagents, significant improvements were obtained in biocompatibility, delivery efficiency, and reproducibility, representing a promising future of this nanocarrier in RNAi-related cancer therapeutics. |
| URI | http://hdl.handle.net/20.500.11897/549440 |
| ISSN | 1530-6984 |
| DOI | 10.1021/acs.nanolett.8b04677 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 深圳研究生院待认领 |
