| Title | Transcranial Direct Current Stimulation Improves Cognitive Function in Mild to Moderate Alzheimer Disease A Meta-Analysis |
| Authors | Cai, Mengjie Guo, Zhiwei Xing, Guoqiang Peng, Haitao Zhou, Liang Chen, Huaping McClure, Morgan A. He, Lin Xiong, Liangwen He, Bin Du, Fei Mu, Qiwen |
| Affiliation | Nanchong Cent Hosp, Dept Radiol, 97 South Renmin Rd, Nanchong 637000, Sichuan, Peoples R China Nanchong Cent Hosp, North Sichuan Med Coll, Clin Med Coll 2, Imaging Inst Rehabil & Dev Brain Funct, 97 South Renmin Rd, Nanchong 637000, Sichuan, Peoples R China Southwest Med Univ, Clin Med Coll, Luzhou, Peoples R China Peking Univ, Hosp 3, Beijing, Peoples R China John Hopkins Univ MCC, Lotus Biotech Com LLC, Rockville, MD USA Univ Texas MD Anderson Canc Ctr, Dept Genitourinary, Houston, TX 77030 USA Harvard Med Sch, Dept Psychiat, Belmont, MA USA |
| Keywords | Alzheimer disease transcranial direct current stimulation meta-analysis cognitive impairment |
| Issue Date | 2019 |
| Publisher | ALZHEIMER DISEASE & ASSOCIATED DISORDERS |
| Abstract | Objective: The purpose of this meta-analysis was to evaluate the therapeutic effect of transcranial direct current stimulation (tDCS) on mild to moderate Alzheimer disease (AD) patients. Materials and Methods: PubMed, Embase, Web of Science, and Cochrane Library were searched until April 2018. The primary cognitive outcomes were extracted from included articles. A crude standardized mean difference with 95% CI was calculated by using fixed or random effect models. Results: Seven studies with 146 patients were included in this meta-analysis. The pooled result showed that tDCS significantly improved cognitive function of AD patients (standardized mean difference=0.37; 95% CI, 0.09-0.65; P=0.01). Subgroup analyses showed that: a single session of tDCS was significantly effective (P<0.05) whereas repeated sessions of tDCS was not lower current density (0.06 mA/cm(2)) (P>0.05) but not higher current density (0.08 mA/cm(2)) significantly improved cognitive performance; stimulating the temporal cortex (P<0.05) but not the left dorsal lateral prefrontal cortex significantly improved cognitive function of AD patients; and improved cognitive function occurred in the group with higher education (P<0.05) but not in the group with lower education. Conclusions: Current evidence suggests that tDCS has a beneficial effect in mild to moderate AD patients. We must be cautious about the results of subgroup analysis given small sample sizes, and further well-designed studies with larger sample size are required to verify these results. |
| URI | http://hdl.handle.net/20.500.11897/549266 |
| ISSN | 0893-0341 |
| DOI | 10.1097/WAD.0000000000000304 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
