| Title | A Visual Circuit Related to Habenula Underlies the Antidepressive Effects of Light Therapy |
| Authors | Huang, Lu Xi, Yue Peng, Yanfang Yang, Yan Huang, Xiaodan Fu, Yunwei Tao, Qian Xiao, Jia Yuan, Tifei An, Kai Zhao, Huan Pu, Mingliang Xu, Fuqiang Xue, Tian Luo, Minmin So, Kwok-Fai Ren, Chaoran |
| Affiliation | Jinan Univ, CNS Regenerat Collaborat Joint Lab, Minist Educ, Guangdong Hongkong Macau Inst CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China Jinan Univ, Affiliated Hosp 1, Dept Neurol, Guangzhou 510632, Guangdong, Peoples R China Jinan Univ, Affiliated Hosp 1, Stroke Ctr, Guangzhou 510632, Guangdong, Peoples R China Jinan Univ, Sch Med, Psychol Dept, Guangzhou 510632, Guangdong, Peoples R China Jinan Univ, Affiliated Hosp 1, Clin Med Res Inst, Guangzhou 510632, Guangdong, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai Mental Hlth Ctr, Shanghai 200030, Peoples R China Univ Sci & Technol China, Div Life Sci & Med, Sch Life Sci,Hefei Natl Lab Phys Sci,Key Lab Brai, Chinese Acad Sci,Microscale Neurodegenerat Disord, Hefei 230026, Anhui, Peoples R China Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100191, Peoples R China Chinese Acad Sci, Ctr Excellence Brain Sci & Intelligent Technol, Wuhan Inst Phys & Math, State Key Lab Magnet Resonance & Atom & Mol Phys, Wuhan 430071, Hubei, Peoples R China Natl Inst Biol Sci, Zhongguancun Life Sci Pk,7 Sci Pk Rd, Beijing 102206, Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Guangdong, Peoples R China Univ Hong Kong, Dept Ophthalmol, Hong Kong, Peoples R China Univ Hong Kong, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226001, Peoples R China |
| Issue Date | 2019 |
| Publisher | NEURON |
| Abstract | Light plays a pivotal role in the regulation of affective behaviors. However, the precise circuits that mediate the impact of light on depressive-like behaviors are not well understood. Here, we show that light influences depressive-like behaviors through a disynaptic circuit linking the retina and the lateral habenula (LHb). Specifically, M4-type melanopsin-expressing retinal ganglion cells (RGCs) innervate GABA neurons in the thalamic ventral lateral geniculate nucleus and intergeniculate leaflet (vLGN/IGL), which in turn inhibit CaMKII alpha neurons in the LHb. Specific activation of vLGN/IGL-projecting RGCs, activation of LHb-projecting vLGN/IGL neurons, or inhibition of postsynaptic LHb neurons is sufficient to decrease the depressive-like behaviors evoked by long-term exposure to aversive stimuli or chronic social defeat stress. Furthermore, we demonstrate that the antidepressive effects of light therapy require activation of the retina-vLGN/IGL-LHb pathway. These results reveal a dedicated retina-vLGN/IGL-LHb circuit that regulates depressive-like behaviors and provide a potential mechanistic explanation for light treatment of depression. |
| URI | http://hdl.handle.net/20.500.11897/549225 |
| ISSN | 0896-6273 |
| DOI | 10.1016/j.neuron.2019.01.037 |
| Indexed | SCI(E) |
| Appears in Collections: | 基础医学院 |
