| Title | The proportion of different BCR-ABL1 transcript types in chronic myeloid leukemia. An international overview |
| Authors | Baccarani, Michele Castagnetti, Fausto Gugliotta, Gabriele Rosti, Gianantonio Soverini, Simona Albeer, Ali Pfirrmann, Markus Bekadja, Mohamed-Amine Entasoltan, Badra Nachi, Mourad Elghandour, Ashraf El Sorady, Manal Abdelfattah, Raafat El Nahass, Yasser Samra, Mohamed Azzazi, Mohammed Elsobki, Ezat Moussa, Mohamed Fahmy, Omar Mattar, Mervat Shehata, Samir Eid Azmy, Emad Bolarinwa, Rahman A. Eid, Samir Khelif, Abderrhaim Hached, Farhat Menif, Samia Rahman, Hafizur Huang, Xiaojun Jiang, Qian Ye, Yuanxin Zhu, Huanling Chen, Suning Varma, Neelam Ganesan, Prasanth Gundeti, Sadashivudu Malhotra, Hemant Radhakrishnan, Vivek S. Kumar, Lalit Sharawat, Surender Kumar Seth, Tulika Ausekar, B. V. Balasubramanian, Poonkuzhali Poopak, Behzad Inokuchi, Koiti Kim, Dong-Wook Al Kindi, Salam Mirasol, Angelina Qari, Mohammed Goh, Yeow Tee Shih, Lee-Yung Branford, Susan Lion, Thomas Valent, Peter Burgstaller, Sonja Thaler, Joseph Labar, Boris Zadro, Renata Mayer, Jiri Zackova, Daniela Faber, Edgar Pallisgaard, Niels Xavier-Mahon, Francois Lippert, Eric Cayuela, Jean Michel Rea, Delphine Millot, Frederic Suttorp, Meinolf Hochhaus, Andreas Niederwieser, Dietger Saussele, Susanne Haferlach, Torsten Jeromine, Sabine Panayiotidis, Panayiotis Conneally, Eibhlin Langabeer, Steve Nagler, Arnon Rupoli, Serena Santoro, Nicola Albano, Francesco Castagnetti, Fausto Ottaviani, Emanuela Rambaldi, Alessandro Stagno, Fabio Molica, Stefano Biagiotti, Caterina Scappini, Barbara Lemoli, Roberto Iurlo, Alessandra Pungolino, Ester Menna, Giuseppe Pane, Fabrizio Gottardi, Enrico Rege-Cambrin, Giovanna Binotto, Gianni Putti, Maria Caterina Falzetti, Franca Visani, Giuseppe Galimberti, Sara Musto, Pellegrino Abruzzese, Elisabetta Breccia, Massimo Giona, Fiorina Chiusolo, Patrizia Sica, Simona Fava, Carmen Ferrero, Dario Tiribelli, Mario Bonifacio, Massimiliano Griskevicius, Laimonas Musteata, Vasile Janssen, Jeroen Prejzner, Witold Sacha, Tomasz Waclaw, Joanna Almeida, Antonio Medina Kulikov, Sergei Turkina, Anna Bogdanovic, Andrija Zupan, Irena Marce, Silvia Cervantes, Francisco Steegmann, Juan Luis Kotlyarchuk, Konstyantyn Milner, Benedict J. Rose, Susan Clench, Tim Waits, Paula Austin, Steve Wickham, Caroline Clark, Richard Apperley, Jane Claudiani, Simone Foroni, Letizia Szydlo, Richard Burt, Emma Bescoby, Ruth Cork, Leanne O'Brien, Stephen Green, Bethaney Hawtree, Sarah Watson, Mark Bengio, Raquel Maria Larripa, Irene Pavlovsky, Carolina Moiraghi, Beatriz Requiao de Pinna, Cristiane Almeida Romani Magalhaes, Gustavo Henrique Pagnano, Katia Funke, Vaneuza Tavares, Renato Sampaio Prado, Adriana Azevedo, Alita Andrade Fogliatto, Laura Bonecker, Simone Centrone, Renato Moellman, Artur Conchon, Monika Centurion, Maria Elida Prado, Ana-Ines Lopez, J. L. Petruzziello, Fara Bendit, Israel |
| Affiliation | Univ Bologna, S Orsola Malpighi Univ Hosp, Dept Expt Diagnost & Specialty Med, Inst Hematol L&A Seragnoli, Bologna, Italy Ludwig Maximilians Univ Munchen, Inst Med Informat Verarbeitung Biometrie & Epidem, Munich, Germany EHU 1er Novembre, Oran, Algeria Alexandria Univ, Alexandria, Egypt NCI, Cairo, Egypt Ain Shams Univ, Cairo, Egypt Cairo Univ, Cairo, Egypt Asuit Univ, Cairo, Egypt Mansoura Univ & Canc Ctr, Mansoura, Egypt Obafemi Awolowo Univ, Ife, Nigeria Teaching Hosp, Sousse, Tunisia Pasteur Inst, Tunis, Tunisia Int Ctr Diarrhoeal Dis, Dhaka, Bangladesh Peking Univ, Peoples Hosp, Bejin, Peoples R China Peking Univ, Inst Hematol, Bejin, Peoples R China Sichuan Univ, West China Hosp, Chengdu, Sichuan, Peoples R China Soochow Univ, Affiliated Hosp 1, Suzhou, Peoples R China PGIMER, Chandigarh, India Canc Inst WIA, Chennai, Tamil Nadu, India Nizams Inst Med Sci, Hyderabad, Telangana, India RK Birla Canc Ctr, Jaipur, Rajasthan, India Tata Med Ctr, Kolkata, India All India Inst Med Sci, New Delhi, India AIIMS, New Delhi, India Shiddheshwar Canc Hosp & Res Ctr, Solapur, India Christian Med Coll & Hosp, Vellore, Tamil Nadu, India Islamic Azada Univ, Tehran, Iran Payvand Clin & Specialty Lab, Tehran, Iran Nippon Med Sch, Tokyo, Japan Catholic Univ Korea, Seoul St Marys Hosp, Leukemia Res Unit, Seoul, South Korea Sultan Qaboos Univ, Muscat, Oman Philippines Gen Hosp, Manila, Philippines King Abdul Aziz Univ Hosp, Jeddah, Saudi Arabia Singapore Gen Hosp, Singapore, Singapore Chang Gung Univ, Linkou, Taiwan Chang Gung Mem Hosp, Linkou, Taiwan Univ Adelaide, Adelaide, SA, Australia Univ South Australia, Adelaide, SA, Australia Childrens Canc Res Inst, Vienna, Austria Med Univ Vienna, Vienna, Austria Klinikum Wels Grieskirchen, Wels, Austria Univ Hosp Ctr Zagreb, Zagreb, Croatia Univ Hosp Brno, Brno, Czech Republic Masaryk Univ, Brno, Czech Republic Palacky Univ, Olomouc, Czech Republic Sjaellands Univ Hosp, Roskilde, Denmark Univ Bordeaux, Bordeaux, France CHU, Brest, France Hop St Louis, Paris, France CHU Poitiers, Poitiers, France Univ Klinikum Carl Gustav Carus, Dresden, Germany Univ Klinikum Jena, Jena, Germany Univ Leipzig, Leipzig, Germany Univ Clin Mannheim, Mannheim, Germany MLL Muenchner Leukaemielab, Munich, Germany Univ Athens, Athens, Greece Laikon Gen Hosp, Athens, Greece St James Hosp, Dublin, Ireland Chaim Sheba Med Ctr, Tel Aviv, Israel Tel Aviv Univ, Tel Aviv, Israel Univ Ancona, Ancona, Italy Azienda Osped Univ Policlin Consorziale, Bari, Italy Univ Bari, Bari, Italy Univ Bologna, Bologna, Italy S Orsola Malpighi Univ Hosp, Bologna, Italy Univ Milan, Bergamo, Italy AAST Papa Giovanni XXIII, Bergamo, Italy Univ Catania, Catania, Italy A Osped Pugliese Ciaccio, Catanzaro, Italy Univ Florence, Florence, Italy Univ Genoa, Genoa, Italy Fdn IRCCS Ca Granda, Milan, Italy Univ Milan, Milan, Italy Osped Niguarda Ca Granda, Milan, Italy Osped Pausillipon, Naples, Italy Univ Federico II, Naples, Italy S Luigi Gonzaga Hosp, Orbassano, Italy Univ Torino, Orbassano, Italy Univ Padua, Padua, Italy Azienda Osped, Clin Ematooncol Pediat, Padua, Italy Univ Perugia, Perugia, Italy Osped S Salvatore, Pesaro, Italy Univ Pisa, Pisa, Italy IRCCS CROB, Rionero In Vulture, Italy S Eugenio Hosp, Rome, Italy Sapienza Univ, Rome, Italy Policlin Gemelli, Rome, Italy Univ Torino, Turin, Italy Univ Udine, Udine, Italy Univ Verona, Verona, Italy Vilnius Univ, Vilnius, Lithuania State Univ Med & Pharm N Testemitanu, Kishinev, Moldova Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands Med Univ Gdansk, Gdansk, Poland Jagiellonian Univ Hosp, Krakow, Poland Inst Portugues Oncol Francisco Gentil, Lisbon, Portugal Minist Healthcare Russian Federat, Natl Res Ctr Hematol, Moscow, Russia Univ Belgrade, Clin Ctr Serbia, Belgrade, Serbia Univ Clin Ctr, Ljubljana, Slovenia Hosp Germans & Trias Pujol, ICO Badalona, Badalona, Spain Hosp Clin Barcelona, IDIBAPS, Barcelona, Spain Hosp Univ Princesa, Madrid, Spain SI Inst Blood Pathol & Transfus Med, Lvov, Ukraine Aberdeen Royal Infirm, Aberdeen, Scotland Birmingham Womens NHS Fdn Trust, Birmingham, W Midlands, England Bristol Royal Infirm & Gen Hosp, Bristol, Avon, England Bristol Genet Lab, Bristol, Avon, England Cardiff & Vale Univ Hlth Board, Cardiff, S Glam, Wales Royal Devon & Exeter NHS Fdn Trust, Exeter, Devon, England Royal Liverpool Univ Hosp, Liverpool, Merseyside, England Imperial Coll London, Hammersmith Hosp, London, England Royal London Hosp, London, England Univ Newcastle, Newcastle Upon Tyne, Tyne & Wear, England Sheffield Diagnost Genet Serv, Sheffield, S Yorkshire, England IIHEMA Acad Nacl Med, Buenos Aires, DF, Argentina Hospitalizat & Clin Res Ctr, FUNDALEU, Buenos Aires, DF, Argentina Hosp JM Ramos Mejia, Buenos Aires, DF, Argentina Fed Univ Hosp Bahia, Salvador, BA, Brazil Minas Gerais Fed Univ, Hosp Clin, Belo Horizonte, MG, Brazil Univ Estadual Campinas, Campinas, SP, Brazil Univ Fed Parana, Curitiba, Parana, Brazil Univ Fed Goias, Hosp Clin, Goiania, Go, Brazil Univ Fed Goias, Clin Hosp, Goiania, Go, Brazil Ctr Hematol & Hematoterapia Pernambuco, Recife, PE, Brazil Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil CEMO INCA, Rio De Janeiro, Brazil Inst Hemomed Oncol & Hematol, Rio De Janeiro, Brazil INCA MS, Rio De Janeiro, Brazil Univ Sao Paulo, Sao Paulo, Brazil Hosp Santa Marcelina, Sao Paulo, Brazil Cent Hosp Asuncion, Asuncion, Paraguay Hosp Maciel, Montevideo, Uruguay Banco Municipal Sangre DC, Caracas, Venezuela |
| Issue Date | 2019 |
| Publisher | LEUKEMIA |
| Abstract | There are different BCR-ABL1 fusion genes that are translated into proteins that are different from each other, yet all leukemogenic, causing chronic myeloid leukemia (CML) or acute lymphoblastic leukemia. Their frequency has never been systematically investigated. In a series of 45503 newly diagnosed CML patients reported from 45 countries, it was found that the proportion of e13a2 (also known as b2a2) and of e14a2 (also known as b3a2), including the cases co-expressing e14a2 and el 3a2, was 37.9% and 62.1%, respectively. The proportion of these two transcripts was correlated with gender, e13a2 being more frequent in males (39.2%) than in females (36.2%), was correlated with age, decreasing from 39.6% in children and adolescents down to 31.6% in patients >= 80 years old, and was not constant worldwide. Other, rare transcripts were reported in 666/34561 patients (1.93%). The proportion of rare transcripts was associated with gender (2.27% in females and 1.69% in males) and with age (from 1.79% in children and adolescents up to 3.84% in patients >= 80 years old). These data show that the differences in proportion are not by chance. This is important, as the transcript type is a variable that is suspected to be of prognostic importance for response to treatment, outcome of treatment, and rate of treatment-free remission. |
| URI | http://hdl.handle.net/20.500.11897/548784 |
| ISSN | 0887-6924 |
| DOI | 10.1038/s41375-018-0341-4 |
| Indexed | SCI(E) |
| Appears in Collections: | 人民医院 |
