| Title | Recent Advances in Understanding FOXN3 in Breast Cancer, and Other Malignancies |
| Authors | Kong, Xiangyi Zhai, Jie Yan, Chengrui Song, Yan Wang, Jing Bai, Xiaofeng Brown, James A. L. Fang, Yi |
| Affiliation | Chinese Acad Med Sci, Dept Breast Surg Oncol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China Peking Union Med Coll, Beijing, Peoples R China Peking Univ Int Hosp, Dept Neurosurg, Beijing, Peoples R China Chinese Acad Med Sci, Dept Pathol, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China Chinese Acad Med Sci, Dept Pancreat Gastr Surg, Natl Canc Ctr, Natl Clin Res Ctr Canc,Canc Hosp, Beijing, Peoples R China Natl Univ Ireland Galway, Discipline Surg, Sch Med, Lambe Inst Translat Res, Galway, Ireland Natl Univ Ireland Galway, Ctr Chromosome Biol, Galway, Ireland |
| Keywords | FOXN3 forkhead function breast cancer malignancy regulation review |
| Issue Date | 2019 |
| Publisher | FRONTIERS IN ONCOLOGY |
| Abstract | FOXN3 (forkhead box N3; CHES1: check point suppressor 1) belongs to the forkhead box (FOX) protein family. FOXN3 displays transcriptional inhibitory activity, and is involved in cell cycle regulation and tumorigenesis. FOXN3 is a tumor suppresser and alterations in FOXN3 are found in of a variety of cancers including melanoma, osteosarcoma, and hepatocellular carcinoma. While the roles of FOXN3 role in some cancers have been explored, its role in breast cancer remains unclear. Here we describe current state of knowledge of FOXN3 functions, and focus on its roles (known and potential) in breast cancer. |
| URI | http://hdl.handle.net/20.500.11897/548106 |
| ISSN | 2234-943X |
| DOI | 10.3389/fonc.2019.00234 |
| Indexed | SCI(E) |
| Appears in Collections: | 国际医院 |
