| Title | Calciotropic Hormones and the Prevalence of Vertebral Fractures in Chinese Postmenopausal Women with Vitamin D Insufficiency: Peking Vertebral Fracture Study |
| Authors | Jiajue, Ruizhi Jiang, Yan Qi, Xuan Wang, Qiuping Wang, Wenbo Pei, Yu Wang, Xiran Huang, Wei Zheng, Xin Ning, Zhiwei Wang, Ou Li, Mei Xing, Xiaoping Yu, Wei Xu, Ling Xia, Weibo |
| Affiliation | Chinese Acad Med Sci, Dept Endocrinol, Key Lab Endocrinol, Minist Hlth,Peking Union Med Coll Hosp,Natl Commi, 1 Shuaifuyuan,Wangfujing St, Beijing 100730, Peoples R China Beijing Liangxiang Hosp, Dept Endocrinol, Beijing 102401, Peoples R China Peking Univ, Dept Endocrinol, Shougang Hosp, Beijing 100144, Peoples R China Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing 100853, Peoples R China Gen Hosp Rocket Force, Dept Cadre Unit, Beijing 100088, Peoples R China Beijing Haidian Hosp, Dept Endocrinol, Beijing 100080, Peoples R China China Rehabil Res Ctr, Dept Endocrinol, Beijing 100068, Peoples R China Beijing Chaoyang Hosp, Dept Endocrinol, Beijing 100020, Peoples R China Chinese Acad Med Sci, Dept Radiol, Peking Union Med Coll Hosp, Shuaifuyuan 1, Beijing 100730, Peoples R China Chinese Acad Med Sci, Dept Obstet & Gynaecol, Peking Union Med Coll Hosp, Beijing 100730, Peoples R China |
| Keywords | Vitamin D insufficiency Secondary hyperparathyroidism Bone turnover markers Bone mineral density Vertebral fractures Chinese postmenopausal women |
| Issue Date | 2019 |
| Publisher | CALCIFIED TISSUE INTERNATIONAL |
| Abstract | This case-control study aimed to examine the effect of high serum parathyroid hormone (PTH) level, especially the effect of secondary hyperparathyroidism (SHPT) related to hypovitaminosis D, on bone metabolism and bone phenotypes. We included a total of 830 Chinese postmenopausal women aged50years with serum 25-hydroxyvitamin D (25(OH)D) level<30ng/ml, among whom 415 women had prevalent vertebral fractures (VFs) and others were age-matched controls. We measured serum levels of 25(OH)D, PTH and bone turnover markers (BTMs), which included C-terminal telopeptide of type I collagen (-CTX), N-aminoterminal prepeptide of type I procollagen (P1NP) and osteocalcin (OC). Bone mineral densities (BMDs) at lumbar spine and femoral neck were quantified by dual-energy X-ray absorptiometry. Morphometric VFs were validated by lateral radiograph of thoracolumbar spine. Compared to fracture-free controls, women with VFs exhibited a higher serum level of PTH and a higher percentage of SHPT (both p<0.05), but had a similar serum level of 25(OH)D (p=0.166). Positive correlations were depicted between PTH and BTMs (all p<0.01), and between 25(OH)D and bone formation markers (p=0.013 for OC, p=0.068 for P1NP), whereas no significant correlation was identified between both calciotropic hormones and BMDs or between 25(OH)D and -CTX (all p>0.05). Increasing PTH was associated with an increased risk of VFs independent of 25(OH)D and BMD [odds ratio (OR) per SD increase in PTH 1.016, 95% confidence interval (95% CI) 1.006-1.027]. Moreover, women with SHPT (i.e., > 68pg/ml) had about three times odds for VF compared to women with normal PTH levels (OR 3.270, 95% CI 1.581-6.760). These data suggest that evaluated serum PTH level might promote the bone remodeling and then lead to increased risks of VFs among Chinese postmenopausal women with vitamin D insufficiency. |
| URI | http://hdl.handle.net/20.500.11897/547955 |
| ISSN | 0171-967X |
| DOI | 10.1007/s00223-019-00531-2 |
| Indexed | SCI(E) |
| Appears in Collections: | 首钢医院 |
