| Title | Clinical features, identification, antimicrobial resistance patterns of Nocardia species in China: 2009-2017 |
| Authors | Huang, Lei Chen, Xingchun Xu, Heping Sun, Liying Li, Chen Guo, Wenchen Xiang, Lili Luo, Guolan Cui, Yancao Lu, Binghuai |
| Affiliation | Peking Univ, Hosp 1, Dept Clin Lab, Beijing, Peoples R China Peoples Hosp Guangxi Zhuang Autonomous Reg, Dept Lab Med, Nanning, Guangxi Zhuang, Peoples R China Xiamen Univ, Hosp 1, Dept Clin Lab, Xiamen, Peoples R China Liuyang City Tradit Chinese Med Hosp, Dept Lab Med, Changsha, Hunan, Peoples R China Weifang Peoples Hosp, Dept Lab Med, Weifang, Shandong, Peoples R China Chongqing Med & Pharmaceut Coll, Affiliated Hosp, Dept Lab Med, Chongqing, Peoples R China Guangxi Med Univ, Affiliated Hosp 4, Med Sci Lab, Liuzhou, Guangxi, Peoples R China Civil Aviat Gen Hosp, Dept Lab Med, Beijing, Peoples R China China Japan Friendship Hosp, Dept Pulm & Crit Care Med, Lab Clin Microbiol & Infect Dis, Beijing, Peoples R China |
| Keywords | Species distribution Antibiotic susceptibility patterns Nocardia farcinica Nocardiosis Trimethoprim-sulfamethoxazole resistance Epidemiological features |
| Issue Date | 2019 |
| Publisher | DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE |
| Abstract | Nocardia spp. is a pathogen responsible for a variety of clinical infections, ranging from skin and soft tissue infections, to the respiratory tract and central nervous system infections. Its epidemiological characteristics, including species distribution, clinical features, and antimicrobial susceptibility profiles, should be under surveillance for the prevention and treatment of nocardiosis. In the present study, over a 9-year period (from 2009 to 2017), 53 non-repetitive Nocardia isolates were collected from 8 tertiary general hospitals of 7 cities in China. These isolates were identified to species level by multilocus sequence analysis(MLSA). The clinical data were also reviewed. The susceptibilities to 10 commonly-used antibiotics for Nocardia were determined by E-test stripes, and the resistance rates, MIC50 and MIC90 to each antibiotic by different species were analyzed. Of 53 Nocardia isolates, N. farcinica was the most common species (24.5%, 13/53), followed by N. cyriacigeorgica (20.8%, 11/53), N. terpenica (15.1%, 8/53), N. abscessus (9.43%, 5/53), N. otitidiscaviarum (7.55%, 4/53), respectively. Furthermore, 31 Nocardia (58.5%) isolates were recovered from lower respiratory tract (sputum and BALF), 15 (283%) from superficial Infection, 3 (5.7%) from pleural effusion, 2 (3.8%) from CSF, and 1 from bone marrow and 1 from synovial fluid, respectively. The antibiotic resistance profiles varied between different Nocardia species. All Nocardia isolates were susceptible to linezolid, followed by imipenem and amikacin (both 92.5% susceptibility rate). N. terpenica, rarely documented elsewhere, showed a different antimicrobial susceptibility profile. In summary, herein, the clinical and antibiotic resistance features of Nocardia species reported would be helpful for understanding the diversity of Nocardia species circulating in China and for decision making in the context of empiric therapy. (C) 2018 Elsevier Inc. All rights reserved. |
| URI | http://hdl.handle.net/20.500.11897/547895 |
| ISSN | 0732-8893 |
| DOI | 10.1016/j.diagmicrobio.2018.12.007 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
