| Title | Association between age and progression of carotid artery atherosclerosis: a serial high resolution magnetic resonance imaging study |
| Authors | Lu, Mingming Peng, Peng Qiao, Huiyu Cui, Yuanyuan Ma, Lu Cui, Bao Cai, Jianming Zhao, Xihai |
| Affiliation | Peoples Liberat Army Gen Hosp, Dept Radiol, Beijing 100853, Peoples R China Tsinghua Univ, Sch Med, Ctr Biomed Imaging, Dept Biomed Engn, Beijing 100084, Peoples R China Logist Univ Chinese Peoples Armed Police Forces, Pingjin Hosp, Dept Radiol, Tianjin, Peoples R China Peking Univ, Hosp 3, Dept Radiol, Beijing, Peoples R China Chinese PLA Bethune Int Peace Hosp, Dept Radiol, Shijiazhuang, Hebei, Peoples R China |
| Keywords | Carotid atherosclerosis Disease progression Risk factors Magnetic resonance imaging |
| Issue Date | 2019 |
| Publisher | INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING |
| Abstract | This study aimed to investigate the association between age and progression of carotid atherosclerotic plaques using serial high resolution magnetic resonance imaging (MRI). Symptomatic patients who had carotid atherosclerosis with 30-70% stenosis were enrolled in this study. Carotid MRI was performed at baseline and follow-up time point (6months after baseline), respectively. The characteristics of carotid plaque progression among different age groups (>75years old, 60-75years old and <60years old) were compared. Logistic regression was performed to relate age with carotid plaque progression. Of recruited 84 patients, 73 (mean age, 66.5 +/- 11.4years old; males, 82.2%) with 96 plaques were included in the final analysis. Compared with younger patients, older ones had significantly higher incidence of calcification in carotid plaques (>75years old: 91.3%, 60-75years old: 65.7% and <60years old: 55.3%, p=0.013), greater annual change of carotid wall volume (>75years old: 39.0 (4.3-104.6) mm(3), 60-75years old: 28.7 (-28.0 to 73.7) mm(3) and <60years old: 4.8 (-27.1-31.9) mm(3), p=0.032) and maximum carotid wall area (>75years old: 6.1 (-3.5 to 17.2) mm(2), 60-75years old: 2.4 (-4.7 to 15.1) mm(2) and <60years old: 1.4 (-5.8 to 6.9) mm(2), p=0.046). Age (OR 1.44; 95% CI 1.10-1.89; p=0.009) and hypertension (OR 4.61; 95% CI 1.41-15. 02; p=0.011) were independent predictors in discriminating upper quartile of annual change of carotid wall volume after adjusting for all clinical factors. Older patients have faster progression rate in carotid plaques than younger ones and age is independently associated with carotid plaque progression. Our findings suggest that the carotid plaques of older patients need to be monitored more frequently. |
| URI | http://hdl.handle.net/20.500.11897/547157 |
| ISSN | 1569-5794 |
| DOI | 10.1007/s10554-019-01538-4 |
| Indexed | SCI(E) |
| Appears in Collections: | 第三医院 |
