| Title | Exercise training improves motor skill learning via selective activation of mTOR |
| Authors | Chen, Kai Zheng, Yuhan Wei, Ji-an Ouyang, Huan Huang, Xiaodan Zhang, Feilong Lai, Cora Sau Wan Ren, Chaoran So, Kwok-Fai Zhang, Li |
| Affiliation | Jinan Univ, Guangdong Hong Kong Macau Inst CNS Regenerat, Joint Int Res Lab CNS Regenerat, Guangzhou 510632, Guangdong, Peoples R China Peking Univ, Drug Discovery Ctr, Shenzhen Grad Sch, Key Lab Chem Genom, Shenzhen 518055, Peoples R China Univ Hong Kong, Sch Biomed Sci, Li Ka Shing Fac Med, Hong Kong, Peoples R China Univ Hong Kong, Li Ka Shing Fac Med, State Key Lab Brain & Cognit Sci, Hong Kong, Peoples R China Nantong Univ, Coinnovat Ctr Neuroregenerat, Nantong 226019, Jiangsu, Peoples R China Guangzhou Regenerat Med & Hlth Guangdong Lab, Guangzhou 510530, Guangdong, Peoples R China |
| Issue Date | 2019 |
| Publisher | SCIENCE ADVANCES |
| Abstract | Physical exercise improves learning and memory, but little in vivo evidence has been provided to illustrate the molecular mechanisms. Here, we show that chronic treadmill exercise activates the mechanistic target of rapamycin (mTOR) pathway in mouse motor cortex. Both ex vivo and in vivo recordings suggest that mTOR activation leads to potentiated postsynaptic excitation and enhanced neuronal activity of layer 5 pyramidal neurons after exercise, in association with increased oligodendrogenesis and axonal myelination. Exercise training also increases dendritic spine formation and motor learning. Together, exercise activates mTOR pathway, which is necessary for spinogenesis, neuronal activation, and axonal myelination leading to improved motor learning. This model provides new insights for neural network adaptations through exercises and supports the intervention of cognitive deficits using exercise training. |
| URI | http://hdl.handle.net/20.500.11897/546973 |
| ISSN | 2375-2548 |
| DOI | 10.1126/sciadv.aaw1888 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 化学生物学与生物技术学院 |
