| Title | Dietary Intake of Fatty Acids, Total Cholesterol, and Stomach Cancer in a Chinese Population |
| Authors | Zhu, Yu-Hui Jeong, Somee Wu, Ming Jin, Zi-Yi Zhou, Jin-Yi Han, Ren-Qiang Yang, Jie Zhang, Xiao-Feng Wang, Xu-Shan Liu, Ai-Ming Gu, Xiao-Ping Su, Ming Hu, Xu Sun, Zheng Li, Gang Li, Li-Ming Mu, Li-Na Lu, Qing-Yi Zhao, Jin-Kou Zhang, Zuo-Feng |
| Affiliation | UCLA, Dept Epidemiol, Fielding Sch Publ Hlth, Los Angeles, CA 90095 USA Jiangsu Prov Ctr Dis Control & Prevent, Dept Noncommunicable Chron Dis Control, Nanjing 210009, Jiangsu, Peoples R China Fudan Univ, Sch Publ Hlth, Dept Epidemiol, Shanghai 200032, Peoples R China Ganyu Cty Ctr Dis Control & Prevent, Ganyu 222100, Peoples R China Dafeng Cty Ctr Dis Control & Prevent, Dafeng 224100, Peoples R China Chuzhou Cty Ctr Dis Control & Prevent, Chuzhou 223200, Peoples R China Tongshan Cty Ctr Dis Control & Prevent, Tongshan 221006, Peoples R China Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100191, Peoples R China SUNY Buffalo, Dept Social & Prevent Med, Buffalo, NY 14260 USA UCLA, David Geffen Sch Med, Dept Med, Ctr Human Nutr, Los Angeles, CA 90095 USA |
| Keywords | Case-control study dietary fatty acids dietary cholesterol stomach cancer China |
| Issue Date | 2019 |
| Publisher | NUTRIENTS |
| Abstract | To investigate the associations between dietary fatty acids and cholesterol consumption and stomach cancer (SC), we analyzed data from a population-based case-control study with a total of 1900 SC cases and 6532 controls. Dietary data and other risk or protective factors were collected by face-to-face interviews in Jiangsu Province, China, from 2003 to 2010. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using multiple unconditional logistic regression models and an energy-adjusted method. The joint associations between dietary factors and known risk factors on SC were examined. We observed positive associations between dietary saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and total cholesterol and the development of SC, comparing the highest versus lowest quarters. Increased intakes of dietary SFAs (p-trend = 0.005; aOR, 1.11; 95% CI, 1.01-1.22 with a 7 g/day increase as a continuous variable) and total cholesterol (p-trend < 0.001; aOR, 1.13; 95% CI, 1.06-1.22 with a 250 mg/day increase as a continuous variable) were monotonically associated with elevated odds of developing SC. Our results indicate that dietary SFAs, MUFAs, and total cholesterol are associated with stomach cancer, which might provide a potential dietary intervention for stomach cancer prevention. |
| URI | http://hdl.handle.net/20.500.11897/546060 |
| DOI | 10.3390/nu11081730 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 公共卫生学院 |
