| Title | Association of plasma retinol levels with incident cancer risk in Chinese hypertensive adults: a nested case-control study |
| Authors | Xie, Liling Song, Yun Lin, Tengfei Guo, Huiyuan Wang, Binyan Tang, Genfu Liu, Chengzhang Huang, Weitong Yang, Yan Ling, Wenhua Zhang, Yan Li, Jianping Huo, Yong Wang, Xiaobin Zhang, Hao Qin, Xianhui Xu, Xiping |
| Affiliation | Southern Med Univ, Nanfang Hosp, Natl Clin Res Ctr Kidney Dis, State Key Lab Organ Failure Res,Renal Div, Guangzhou 510515, Guangdong, Peoples R China China Agr Univ, Coll Food Sci & Nutr Engn, Beijing Adv Innovat Ctr Food Nutr & Human Hlth, Beijing 100083, Peoples R China Anhui Med Univ, Inst Biomed, Hefei 230032, Anhui, Peoples R China Shenzhen Evergreen Med Inst, Shenzhen 518057, Peoples R China Nanning Maternal & Child Hlth Care Hosp, Nanning 530011, Peoples R China Sun Yat Sen Univ, Sch Publ Hlth Shenzhen, Guangzhou 510006, Guangdong, Peoples R China Guangdong Engn Technol Ctr Nutr Transformat, Guangzhou 510080, Guangdong, Peoples R China Sun Yat Sen Univ, Sch Publ Hlth, Dept Nutr, Guangzhou 510080, Guangdong, Peoples R China Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Populat Family & Reprod Hlth, Baltimore, MD 21205 USA |
| Keywords | Retinol Digestive cancers Non-digestive cancers Hypertensive populations |
| Issue Date | 2019 |
| Publisher | BRITISH JOURNAL OF NUTRITION |
| Abstract | We aimed to investigate the association between plasma retinol and incident cancer among Chinese hypertensive adults. We conducted a nested case-control study, including 231 patients with incident cancer and 231 matched controls during a median 4 center dot 5-year follow-up of the China Stroke Primary Prevention Trial. There was a significant, inverse association between retinol levels and digestive system cancer (per 10 mu g/dl increases: OR 0 center dot 79; 95 % CI 0 center dot 69, 0 center dot 91). When compared with participants in the first quartile of retinol (< 52 center dot 3 mu g/dl), a significantly lower cancer risk was found in participants in quartile 2-4 ( >= 52 center dot 3 mu g/dl: OR 0 center dot 31; 95 % CI 0 center dot 13, 0 center dot 71). However, there was a U-shaped association between retinol levels and non-digestive system cancers where the risk of cancers decreased (although not significantly) with each increment of plasma retinol (per 10 mu g/dl increases: OR 0 center dot 89; 95 % CI 0 center dot 60, 1 center dot 31) in participants with retinol < 68 center dot 2 mu g/dl, and then increased significantly with retinol (per 10 mu g/dl increase: OR 1 center dot 65; 95 % CI 1 center dot 12, 2 center dot 44) in participants with retinol >= 68 center dot 2 mu g/dl. In conclusion, there was a significant inverse dose-response association between plasma retinol and the risk of digestive system cancers. However, a U-shaped association was observed between plasma retinol and the risk of non-digestive cancers (with a turning point approximately 68 center dot 2 mu g/dl). |
| URI | http://hdl.handle.net/20.500.11897/545871 |
| ISSN | 0007-1145 |
| DOI | 10.1017/S000711451900120X |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
