| Title | X chromosome-linked long noncoding RNA lnc-XLEC1 regulates c-Myc-dependent cell growth by collaborating with MBP-1 in endometrial cancer |
| Authors | Li, Fang Li, Hua Zhang, Liyuan Li, Wei Deng, Jiegiong An, Mingxing Wu, Siqi Lu, Xiaoxiao Ma, Rui Wang, Yirong Guo, Binbin Lu, Jiachun Zhou, Yifeng |
| Affiliation | Soochow Univ, Med Coll, Dept Genet, Suzhou, Peoples R China Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing, Peoples R China Soochow Univ, Affiliated Hosp 2, Dept Radiotherapy & Oncol, Suzhou, Peoples R China LMU, Fac Languages & Literatures, Dept English Study, Munich, Germany Guangzhou Med Univ, Affiliated Hosp 1, Inst Chem Carcinogenesis, Sch Publ Hlth,State Key Lab Resp Dis,Dept Epidemi, Guangzhou, Guangdong, Peoples R China |
| Keywords | X chromosome EC lnc-XLEC1 MBP-1 c-Myc |
| Issue Date | 2019 |
| Publisher | INTERNATIONAL JOURNAL OF CANCER |
| Abstract | LncRNAs (long noncoding RNAs) are noncoding transcripts that are more than 200 nt long and have been described as the largest subclass in the noncoding transcriptome in humans. Although studies of lncRNAs in cancer have been continuing for a long time, no much has been known about X chromosome-linked lncRNAs. Here, by using RNA-seq we report the identification of a new X chromosome-linked lncRNA (lnc-XLEC1) that is aberrantly downregulated during the development of endometrial carcinoma (EC). The overexpression of lnc-XLEC1 reduces the migration and proliferation of EC cells. Flow cytometry analysis indicated that lnc-XLEC1 overexpression resulted in a substantial accumulation of EC cells in the G1 phase. In addition, lnc-XLEC1 had inhibitive effects that may result from its collaboration with MBP-1 during the suppression of the c-Myc expression and the negative regulating of the Cdk/Rb/E2F pathway. The anti-tumor effects of lnc-XLEC1 on EC progression suggest that lnc-XLEC1 has some potential value in anti-carcinoma therapies and deserves further investigation. Our study reported for the first time that the lnc-XLEC1 might be related to the incidence and prognosis of EC. Moreover, we discovered that this process might be related to somatic X dosage compensation and skewed X chromosome inactivation (SXCI). |
| URI | http://hdl.handle.net/20.500.11897/545857 |
| ISSN | 0020-7136 |
| DOI | 10.1002/ijc.32166 |
| Indexed | SCI(E) EI |
| Appears in Collections: | 第三医院 |
