| Title | An international Delphi survey helped develop consensus-based core outcome domains for trials in peritoneal dialysis |
| Authors | Manera, Karine E. Tong, Allison Craig, Jonathan C. Shen, Jenny Jesudason, Shilpa Cho, Yeoungjee Sautenet, Benedicte Teixeira-Pinto, Armando Howell, Martin Wang, Angela Yee-Moon Brown, Edwina A. Brunier, Gillian Perl, Jeffrey Dong, Jie Wilkie, Martin Mehrotra, Rajnish Pecoits-Filho, Roberto Naicker, Saraladevi Dunning, Tony Scholes-Robertson, Nicole Johnson, David W. |
| Affiliation | Univ Sydney, Sydney Sch Publ Hlth, Sydney, NSW, Australia Childrens Hosp Westmead, Ctr Kidney Res, Cnr Hawkesbury Rd & Hainsworth St, Sydney, NSW 2145, Australia Flinders Univ S Australia, Coll Med & Publ Hlth, Adelaide, SA, Australia Univ Calif Los Angeles, Med Ctr, Los Angeles Biomed Res Inst Harbor, Div Nephrol & Hypertens, Torrance, CA 90024 USA Royal Adelaide Hosp, Cent & Northern Adelaide Renal & Transplantat Ser, Adelaide, SA, Australia Univ Adelaide, Adelaide, SA, Australia Princess Alexandra Hosp, Dept Nephrol, Brisbane, Qld, Australia Univ Queensland, Australian Kidney Trials Network, Brisbane, Qld, Australia Univ Tours, Tours, France Tours Hosp, Dept Nephrol Hypertens Dialysis Kidney Transplant, Tours, France INSERM, U1246, Methods Patient Ctr Outcomes & Hlth Res, Tours, France Univ Hong Kong, Queen Mary Hosp, Dept Med, Hong Kong, Peoples R China Imperial Coll, Hammersmith Hosp, Renal & Transplant Ctr, London, England Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada Univ Toronto, St Michaels Hosp, Dept Med, Div Nephrol, Toronto, ON, Canada Peking Univ, Hosp 1, Dept Med, Renal Div, Beijing, Peoples R China Sheffield Teaching Hosp Natl Hlth Serv Fdn Trust, Dept Nephrol, Sheffield, S Yorkshire, England Univ Washington, Dept Med, Div Nephrol, Kidney Res Inst, Seattle, WA 98195 USA Univ Washington, Dept Med, Div Nephrol, Harborview Med Ctr, Seattle, WA 98195 USA Pontificia Univ Catolica Parana, Sch Med, Curitiba, Parana, Brazil Arbor Res Collaborat Hlth, Ann Arbor, MI USA Univ Witwatersrand, Fac Hlth Sci, Sch Clin Med, Dept Internal Med, Johannesburg, South Africa South Bank Tech & Further Educ, Brisbane, Qld, Australia Translat Res Inst, Brisbane, Qld, Australia Univ Queensland, Princess Alexandra Hosp, Ctr Kidney Dis Res, Brisbane, Qld, Australia |
| Keywords | core outcome sets kidney disease outcomes patient-centered care peritoneal dialysis trials |
| Issue Date | 2019 |
| Publisher | KIDNEY INTERNATIONAL |
| Abstract | Shared decision-making about clinical care options in end-stage kidney disease is limited by inconsistencies in the reporting of outcomes and the omission of patient-important outcomes in trials. Here we generated a consensus-based prioritized list of outcomes to be reported during trials in peritoneal dialysis (PD). In an international, online, three-round Delphi survey, patients/caregivers and health professionals rated the importance of outcomes using a 9-point Likert scale (with 7-9 indicating critical importance) and provided comments. Using a Best-Worst Scale (BWS), the relative importance of outcomes was estimated. Comments were analyzed thematically. In total, 873 participants (207 patients/caregivers and 666 health professionals) from 68 countries completed round one, 629 completed round two and 530 completed round three. The top outcomes were PDrelated infection, membrane function, peritoneal dialysis failure, cardiovascular disease, death, catheter complications, and the ability to do usual activities. Compared with health professionals, patients/caregivers gave higher priority to six outcomes: blood pressure (mean difference, 0.4), fatigue (0.3), membrane function (0.3), impact on family/friends (0.1), peritoneal thickening (0.1) and usual activities (0.1). Four themes were identified that underpinned the reasons for ratings: contributing to treatment longevity, preserving quality of life, escalating morbidity, and irrelevant and futile information and treatment. Patients/caregivers and health professionals gave highest priority to clinical outcomes. In contrast to health professionals, patients/caregivers gave higher priority to lifestyle-related outcomes including the impact on family/friends and usual activities. Thus, prioritization will inform a core outcome set to improve the consistency and relevance of outcomes for trials in PD. |
| URI | http://hdl.handle.net/20.500.11897/545591 |
| ISSN | 0085-2538 |
| DOI | 10.1016/j.kint.2019.03.015 |
| Indexed | SCI(E) |
| Appears in Collections: | 第一医院 |
