| Title | The Correlation Between [Ga-68]DOTATATE PET/CT and Cell Proliferation in Patients With GEP-NENs |
| Authors | Yu, Jiangyuan Li, Nan Li, Jie Lu, Ming Leal, Jeffrey P. Tan, Huangying Su, Hua Fan, Yang Zhang, Yan Zhao, Wei Zhu, Hua Pomper, Martin G. Zhou, Yun Yang, Zhi |
| Affiliation | Peking Univ Canc Hosp & Inst, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Dept Nucl Med, Beijing 100142, Peoples R China Peking Univ Canc Hosp & Inst, Minist Educ Beijing, Key Lab Carcinogenesis & Translat Res, Dept Gastrointestinal Oncol, Beijing 100142, Peoples R China Johns Hopkins Univ, Sch Med, Russell H Morgan Dept Radiol & Radiol Sci, Baltimore, MD USA China Japan Friendship Hosp, Dept Integrat Oncol, Beijing, Peoples R China Washington Univ, Sch Med, Dept Radiol, Campus Box 8225,510 S Kingshighway Blvd, St Louis, MO 63110 USA |
| Keywords | Neuroendocrine tumor Somatostatin receptor PET CT [Ga-68]DOTATATE Cell proliferation |
| Issue Date | 2019 |
| Publisher | MOLECULAR IMAGING AND BIOLOGY |
| Abstract | Purpose Objectives of the study are to analyze the correlation between [Ga-68]DOTATATE positron emission tomography (PET)/X-ray computed tomography (CT) measurements and various biological characteristics of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs), and to determine optimal cutoff value of SUVmax (standard uptake value) to differentiate neuroendocrine tumors (NETs) and neuroendocrine cancers (NECs). Procedures Of the GEP-NEN cases (73 males, 53 females; age 18-77 years) with pathologically proven primary and/or metastatic lesions, 126 were studied. All of the short axes of lesions were larger than 0.5 cm in order to avoid the partial volume effect. Patients fasted for 6 h before the PET/CT scans. The dose of [Ga-68]DOTATATE was 100-200 MBq and the acquisition began at 1 h after injection. The lesion with the highest SUVmax in each patient was analyzed. Results In the total sample, the sensitivity of [68Ga]DOTATATE was 69.05 %. The sensitivities were significantly different among G1, G2, and G3 groups (72.22 %, 91.53 %, and 40.82 %, respectively; p < 0.01). The SUVmax of the G3 group was lowest. We also found that the sensitivity and SUVmax were significantly higher (p < 0.05) in patients with pancreatic NENs (Pan-NENs) than in patients with gastrointestinal NENs (Gi-NENs) and unknown primary NENs (Up-NENs). A significant negative correlation between SUVmax and Ki-67 was found (r = - 0.429, p < 0.01). Using SUVmax to differentiate neuroendocrine tumors (NETs) and neuroendocrine cancers (NECs), the area under the ROC curve (AUC) was 0.771 and the cutoff value of SUVmax was 11.25 (sensitivity 79.2 %, specificity 65.3 %). However, Pan-NENs did not show any statistical significance results in correlation and ROC analysis. Conclusion [Ga-68]DOTATATE PET/CT results showed a negative correlation with GEP-NEN cell proliferation and were complementary to Ki-67. Pan-NENs were different from Gi-NENs and Up-NENs when compared to somatostatin receptor expression. |
| URI | http://hdl.handle.net/20.500.11897/544944 |
| ISSN | 1536-1632 |
| DOI | 10.1007/s11307-019-01328-3 |
| Indexed | SCI(E) |
| Appears in Collections: | 北京肿瘤医院 |
